glycogen synthesis
The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans
... hepatic glycogen synthesis under conditions of intravenous glucose administration and suppressed glucagon secretion ...of glycogen might be expected to reflect glucose uptake by the liver (1), the ...
8
Impaired hepatic glycogen synthesis in glucokinase deficient (MODY 2) subjects
... hepatic glycogen content was similar in glucokinase- deficient and control subjects (279 6 20 vs 284 6 14 mM; mean 6 SEM), and increased in both groups after the meals with a continuous pattern throughout the ...
8
Sources of carbon for hepatic glycogen synthesis in the conscious dog
... hepatic glycogen synthesis, we studied nine 42-h fasted conscious dogs given a continuous intraduodenal infusion of glucose, labeled with [1-13C]glucose and [3-3H]glucose, at 8 ...min. Glycogen ...
11
PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance
... to glycogen (PTG) is a scaffolding protein that targets protein phosphatase 1α (PP1α) to glycogen, and links it to enzymes involved in glycogen synthesis and ...and glycogen ...
11
Role of the direct and indirect pathways for glycogen synthesis in rat liver in the postprandial state
... hepatic glycogen synthesis in the postprandial state was studied in meal- fed rats chronically cannulated in the portal ...of glycogen synthesis in liver during meal-feeding was found to be ...
8
Dichloroacetate inhibits glycolysis and augments insulin stimulated glycogen synthesis in rat muscle
... The decrease in plasma lactate during dichloroacetate (DCA) treatment is attributed to stimulation of lactate oxidation. To determine whether DCA also inhibits lactate production, we measured glucose metabolism in ...
8
Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen
... liver glycogen during a 24-hour fast despite the fact that glycogenolysis is known to be stim- ulated during fasting as a result of increases in circu- lating glucagon levels ...increased glycogen levels ...
11
Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non insulin dependent diabetes mellitus
... Total glycogen synthase activity was reduced approximately 38% and glycogen content was approximately 30% lower in ...between glycogen content and glycogen synthase activity (r = ...muscle ...
8
Glycogen synthesis correlates with androgen-dependent growth arrest in prostate cancer
... on glycogen metabolism in pros- tate cancer were investigated using the PC3-AR model ...cells. Glycogen content nor- malized to cell count was determined after different incu- bation times ...1A). ...
10
Structure of GlgS from Escherichia coli suggests a role in protein–protein interactions
... The protein surface was inspected for other solvent- exposed residues that may have functional significance. Tyrosines, which are often involved in signal transduction pathways through their phosphorylation, are also ...
7
Phytanic acid stimulates glucose uptake in a model of skeletal muscles, the primary porcine myotubes
... of glycogen synthesis, com- pared to the effect of insulin alone (45% ...and glycogen synthesis is not a general effect of fatty acids, as the same concentration of PAM did not cause these ...
12
In vitro reversal of the fasting state of liver metabolism in the rat Reevaluation of the roles of insulin and glucose
... eigher glycogen synthesis or lipogenesis. The best precursor for glycogen formation was fructose, whereas lactate (pyruvate) was most efficient in ...stimulate, glycogen deposition or fatty ...
12
Mechanism of impaired insulin stimulated muscle glucose metabolism in subjects with insulin dependent diabetes mellitus
... the glycogen synthesis rate with the incremental change in G-6-P makes it possible to determine the rate-con- trolling step for glycogen synthesis (10, ...If glycogen synthase were ...
7
Effects of Supplementation with Glutathione and its Precursors on Athlete Performance
... muscle glycogen synthesis, muscle protein synthesis and muscle tissue growth, reduction in muscle soreness and improved muscle tissue repair, enhanced buffering capacity, and improved high intensity ...
8
Characterization of cellular defects of insulin action in type 2 (non insulin dependent) diabetes mellitus
... 14CO2; glycogen synthesis was calculated as the difference between body glucose disposal and ...Glycolysis, glycogen synthesis, and glucose oxidation were reduced in NIDDM patients (P < ...
12
Rhodiola crenulata extract regulates hepatic glycogen and lipid metabolism via activation of the AMPK pathway
... acid synthesis, and increases fatty acid oxidation by regulating gene expression and downstream enzymatic ...regulated glycogen synthesis and lipogenesis in hepatic ...hepatic glycogen and ...
10
The PI3K/AKT pathway in obesity and type 2 diabetes
... promotes glycogen synthesis in L6 myotubes ...increases glycogen synthesis in skeletal muscle, activating glycogen synthase (GS) to redirect glucose-6-phosphate to glycogen and ...
14
Nuclear Magnetic Resonance Studies of Glucose Metabolism in Non-Insulin-Dependent Diabetes Mellitus Subjects
... In muscle from normal, healthy subjects the rate of glycogen synthesis is con- trolled by the glucose transport/hexoki- nase activity step and not by the activity of the muscle glycogen [r] ...
8
Skeletal muscle glycogenolysis is more sensitive to insulin than is glucose transport/phosphorylation Relation to the insulin mediated inhibition of hepatic glucose production
... muscle glycogen synthase activity and the decrease in the rate of muscle glycogenolysis and in the G6P concentration; (b) the inhibition of hepatic glucose ...muscle glycogen synthesis was not ...
13
The AMP activated protein kinase α2 catalytic subunit controls whole body insulin sensitivity
... metabolism. To better understand the physiological role of AMPK, we generated a knockout mouse model in which the AMPKa2 catalytic subunit gene was inactivated. AMPK a 2 –/– mice presented high glucose levels in the fed ...
9