Glycolytic Metabolism
Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression
... on glycolytic metabolism (19,20) and high lactate levels (up to 40 mmol/g wet weight, equivalent to 57 mM) have been reported to correlate with a tendency to metastasis ...
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The acute effects of controlled breathing training in swimming on glycolytic metabolism.
... oven t H a t ion during exercise such as breathholding in swimming can result In an elevated arterial PCOg above normal limits (35-45 m m Hg ) . It has been stated that high PCOg was usually associated with respiratory ...
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Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma
... suppress glycolytic metabolism, and decrease MYCN protein expression in ...formation. Glycolytic metabolic activity decreased with DFMO treatment in ...inhibits glycolytic metabolism ...
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Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
... key glycolytic enzyme were consistent with the view that acquisition of a high glycolytic metabolism severely lim- its the formation of CD8 + T cell memory in ...
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Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells
... enhanced metabolism from glycolysis [1, 10, 12]. Enhanced glucose metabolism is a key hallmark of functional Lin28 within these ...glucose metabolism via increased glucose uptake and an increase in ...
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MiR-361-5p inhibits glycolytic metabolism, proliferation and invasion of breast cancer by targeting FGFR1 and MMP-1
... inhibit glycolytic flux and force the cells to rely on mitochondrial oxidative phosphorylation ...between glycolytic metabolism and mitochondrial oxidative ...
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1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma
... the metabolism, the changes at 48 h are of more difficult interpretation, being the combination of multiple ...enhanced glycolytic metabolism and high lactate produc- tion ...
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Portuguese propolis disturbs glycolytic metabolism of human colorectal cancer in vitro
... lytic metabolism of cancer cells has not yet been investi- ...cell metabolism, as assessed by the effects on the rates of glucose consump- tion and lactate production (Figure ...for glycolytic ...
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Glycolytic metabolism influences global chromatin structure
... DNA damage, if unrepaired, can serve as a signal triggering cell death [19]. The compromised efficacy of DNA repair in 2-DG-treated cancer cells would predict an increased sensitivity to DNA damage agents. We tested this ...
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MicroRNA regulation of glycolytic metabolism in glioblastoma multiforme
... of glycolytic genes caused by somatic mutations in the encoding genes or in the oncogenes and tumour suppressor genes that regulate the expression of glycolytic ...the glycolytic rates of various GBM ...
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Silencing the Girdin gene enhances radio-sensitivity of hepatocellular carcinoma via suppression of glycolytic metabolism
... Girdin binds to Giα3 and then stimulates the PI3K/ AKT signaling pathway, which participates in the prolif- eration, invasion, and metastasis of malignant tumors [34, 35]. HIF-1α is a hypoxia-induced transcription fac- ...
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Enhanced glycolytic metabolism supports transmigration of brain infiltrating macrophages in multiple sclerosis
... It is known that knockdown of MCT-4 reduces glycolytic enzymes in macrophages (34). Also, as described earlier, siRNA- mediated knockdown of MCT-4 decreased the expression of LDHA and secretion of lactate in BMDMs ...
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Classical monocytes maintain ex vivo glycolytic metabolism and early but not later inflammatory responses in older adults
... We have previously demonstrated that aging impairs mito- chondrial respiratory capacity in classical monocytes [16]. Immune cells require increased ATP production to meet en- ergy demands during activation or ...
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Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122
... respiration, we measured oxygen consumption after PDK4 knockdown; our data showed that siRNA knockdown of PDK4 increased basal and maximal oxygen consumption rate (Figure 3H). These results support the notion that active ...
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SOX2 as a novel contributor of oxidative metabolism in melanoma cells
... OxPhos metabolism, we determined metabolic markers in SSM2c cells, characterized by high SOX2 levels, and in 501-Mel, which show low/no SOX2 expression, upon knock-down or ectopic expression of SOX2, ...the ...
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Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss
... and glycolytic metabolism; however simultaneous inhibition of these pathways with AZD8055/2-DG combination was significantly more effective at reducing tumor volume and ...and glycolytic ...
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The glycolytic oscillator
... The demonstration of oscillations in glycolysis of yeast cells and in cell-free extracts of yeast was the first indication that periodic activities of biological systems might be caused [r] ...
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Glycolytic and Associated Enzymes of Rainbow Trout (Oncorhynchus Mykiss) Red Cells: In Vitro and In Vivo Studies
... Maximal activities of glycolytic and associated enzymes of rainbow trout red cells Enzyme Glycolytic enzymes Glycogen phosphorylase Phosphoglucomutase Hexokinase Phosph.oglucoisomerase P[r] ...
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Rap1p Requires Gcr1p and Gcr2p Homodimers to Activate Ribosomal Protein and Glycolytic Genes, Respectively
... Burnette, W. N., 1981 “Western blotting”: electrophoretic transfer Uemura, H., and Y. Jigami, 1995 Mutations in GCR1, a transcrip- of proteins from sodium dodecyl sulfate-polyacrylamide gels to tional activator of ...
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A mutation affecting the lactate dehydrogenase locus Ldh-1 in the mouse. II. Mechanism of the LDH-A deficiency associated with hemolytic anemia.
... Glycolytic intermediates and metabolic activity of erythrocytes: Concentrations of glycolytic intermedi- ates and adenine nucleotides, as well as glucose con- sumption, lact[r] ...
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