Glycoprotein B
Structure Based Mutations in the Herpes Simplex Virus 1 Glycoprotein B Ectodomain Arm Impart a Slow Entry Phenotype
... ABSTRACT Glycoprotein B (gB) is the conserved herpesvirus fusion protein, and it is required for the entry of herpesviruses. The structure of the postfusion conforma- tion of gB has been solved for several ...
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Intrahost Dynamics of Human Cytomegalovirus Variants Acquired by Seronegative Glycoprotein B Vaccinees
... the glycoprotein B (gB)/MF59 vaccine, which aims to prevent pregnant women from acquiring HCMV, is the most successful HCMV vac- cine tested clinically to ...
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Virion-Incorporated Glycoprotein B Mediates Transneuronal Spread of Pseudorabies Virus
... Transneuronal spread of pseudorabies virus (PRV) is a multistep process that requires several virally encoded proteins. Previous studies have shown that PRV glycoprotein B (gB), a component of the viral ...
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Identification of Functional Domains in Herpes Simplex Virus 2 Glycoprotein B
... Glycoprotein B (gB) is conserved throughout the Herpesviri- dae family and seems likely to have a function in membrane fusion for each virus, although significant details may vary and some homologs may have ...
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Antigenic Domain 1 Is Required for Oligomerization of Human Cytomegalovirus Glycoprotein B
... Human cytomegalovirus (HCMV) glycoprotein B (gB) is an abundant virion envelope protein that has been shown to be essential for the infectivity of HCMV. HCMV gB is also one of the most immunogenic virus- ...
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Effects of Truncation of the Carboxy Terminus of Pseudorabies Virus Glycoprotein B on Infectivity
... membrane glycoprotein B (gB) of herpes simplex virus 1 (HSV-1) are the most highly conserved glycoproteins within the family Herpesviridae and are present in members of each herpesvirus ...
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Receptor-Binding Properties of a Soluble Form of Human Cytomegalovirus Glycoprotein B
... HCMV glycoprotein complexes that possess the ability to bind immobilized heparin (14, ...of glycoprotein B (gB) (also known as gpUL55) was bound ...
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Immune Reactivity of Human Sera to the Glycoprotein B of Human Herpesvirus 7
... The glycoprotein B (gB) is highly conserved among distinct human herpesvirus 7 (HHV-7) strains. Similarly to other herpesvirus glycoproteins, gB has been assumed to induce a specific human immune response. ...
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Glycoprotein B Cleavage Is Important for Murid Herpesvirus 4 To Infect Myeloid Cells
... Glycoprotein B (gB) is a conserved herpesvirus virion component implicated in membrane fusion. As with many— but not all— herpesviruses, the gB of murid herpesvirus 4 (MuHV-4) is cleaved into ...
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Characterization of a Discontinuous Neutralizing Epitope on Glycoprotein B of Human Cytomegalovirus
... Human cytomegalovirus (HCMV) is a ubiquitously distributed pathogen that causes severe disease in immunosuppressed pa- tients and newborn infants infected in utero. The viral envelope glycoprotein B (gB) is ...
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Low pH-Induced Conformational Change in Herpes Simplex Virus Glycoprotein B
... Herpesviruses can enter host cells using pH-dependent endocytosis pathways in a cell-specific manner. Envelope glycoprotein B (gB) is conserved among all herpesviruses and is a critical component of the ...
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Proteolytic Processing of Human Cytomegalovirus Glycoprotein B Is Dispensable for Viral Growth in Culture
... Glycoprotein B (gB) of human cytomegalovirus (HCMV), which is considered essential for the viral life cycle, is proteolytically processed during maturation. Since gB homologues of several other ...
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Definition and Distribution Analysis of Glycoprotein B Gene Alleles of Human Herpesvirus 7
... herpesviruses, glycoprotein B (gB) of human herpesvirus 7 (HHV-7) is believed to play a major role in virus infection and as a target of the host immunogenic ...A, B, C, D, E, and ...
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Calnexin acts as a molecular chaperone during the folding of glycoprotein B of human cytomegalovirus.
... The glycoprotein complex is now termed glycoprotein B (gB), since it has sequence homology to the herpes simplex virus gB ...I glycoprotein, with gp116 represent- ing the surface component and ...
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Mutational Evidence of Internal Fusion Loops in Herpes Simplex Virus Glycoprotein B
... Herpes simplex virus type 1 (HSV-1) glycoprotein B (gB) is one of four glycoproteins necessary and sufficient for HSV cellular entry. Recently, the crystal structures of HSV-1 gB and vesicular stomatitis ...
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Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops
... Herpesviridae, glycoprotein B (gB) is re- sponsible for driving fusion of the viral envelope with the host cell membrane for entry upon receptor binding and activation by the viral gH/gL ...
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Species Specificity of Macaque Rhadinovirus Glycoprotein B Sequences
... All members of the Herpesviridae family contain sequences for a highly conserved glycoprotein B (gB) gene. We investigated the phylogenetic relationships of gB sequences from eight independent rhadinovirus ...
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Disulfide Bond Configuration of Human Cytomegalovirus Glycoprotein B
... Glycoprotein B (gB) is the most highly conserved of the envelope glycoproteins of human ...the glycoprotein (amino acids 1 to 750) was constructed and expressed in insect ...
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Characterization of Murine Gammaherpesvirus 68 Glycoprotein B
... Glycoprotein B (gB) plays an important role in the entry of both Epstein-Barr virus and Kaposi’s sarcoma-associated her- pesvirus virions into cells. Kaposi’s sarcoma-associated herpes- virus gB binds to ...
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Glycoprotein 110, the Epstein-Barr virus homolog of herpes simplex virus glycoprotein B, is essential for Epstein-Barr virus replication in vivo.
... relatives in the other human herpesviruses (9, 10, 13, 16, 27, 28). This additional component appears to be important for infection of B lymphocytes but not for infection of epithelial cells (16). Perhaps ...
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