glycoprotein IIb–IIIa
Effect of Platelet Glycoprotein IIb/IIIa PLA2 Polymorphism on Severity of Pulmonary Thromboembolism
... platelet glycoprotein IIb/IIIa PLA2 polymorphism was shown to be an independent and dose-dependant risk factor for PTE and recurrent PTE (2, 7, ...platelet glycoprotein IIb/IIIa ...
9
Incidence of post myocardial infarction left ventricular thrombus formation in the era of primary percutaneous intervention and glycoprotein IIb/IIIa inhibitors. A prospective observational study
... Fifty-seven men and 35 women were studied, with a mean age of 60 years (range: 30 – 87 years) (Table 1). Forty-one patients had an inferior MI involving the right coronary artery, 37 had an anterior MI with the left ...
5
Absence of ligands bound to glycoprotein IIB IIIA on the exposed surface of a thrombus may limit thrombus growth in flowing blood
... of glycoprotein IIb-IIIa (GPIIb-IIIa) and its ligands fibrinogen and von Willebrand factor (vWf) on platelets which had adhered under flow ...
16
Intraprocedural Thrombus Formation during Coil Placement in Ruptured Intracranial Aneurysms: Treatment with Systemic Application of the Glycoprotein IIb/IIIa Antagonist Tirofiban
... as intravenous aspirin. Occlusions are sometimes treated by intraarterial thrombolysis with urokinase or recombinant tis- sue plasminogen activator, often causing severe rebleeding at the aneurysm site and elsewhere. The ...
6
Efficacy and safety of fondaparinux versus enoxaparin in patients undergoing percutaneous coronary intervention treated with the glycoprotein IIb/IIIa inhibitor tirofiban
... As anticoagulants, unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) have success- fully been used to reduce the incidence of ischemic complications in patients with ACS undergoing percu- taneous ...
7
Retention of the glycoprotein IIb IIIa complex in the isolated platelet cytoskeleton Effects of separable assembly of platelet pseudopodal and contractile cytoskeletons
... (glycoprotein IIb- III(a) with the cytoskeleton, 125I-surface labeled human platelets washed by gel-filtration were activated under conditions which allow selective assembly of the platelet ...
11
Platelet inhibitors in non-ST-segment elevation acute coronary syndromes and percutaneous coronary intervention: glycoprotein IIb/IIIa inhibitors, clopidogrel or both?
... of glycoprotein (Gp) IIb/IIIa receptor antagonists remains controversial and these agents are infrequently utilized during non-ST-segment elevation acute coronary syndromes (NSTE-ACS) despite ...
10
A new variant of Glanzmann's thrombasthenia (Strasbourg I) Platelets with functionally defective glycoprotein IIb IIIa complexes and a glycoprotein IIIa 214Arg 214Trp mutation
... of glycoprotein (GP) IIb-IIIa (alpha IIb beta 3) complexes, the platelet fibrinogen receptor, were revealed by SDS-PAGE, crossed immunoelectrophoresis, and antibody ...
11
Detection of High-Risk Atherosclerotic Plaques with Ultrasound Molecular Imaging of Glycoprotein IIb/IIIa Receptor on Activated Platelets
... GP IIb/IIIa coverage of the endothelium were correlated with both NC/FC and vulnerability ...GP IIb/IIIa on activated and adhered platelets. Thus, these GP IIb/IIIa receptors ...
13
Interaction of asialo von Willebrand factor with glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and mediates platelet aggregation
... aggregation in the absence of any other stimulus. Asialo vWF, unlike the native molecule, does not require ristocetin to interact with platelets. Agglutination induced by ristocetin is largely independent of active ...
7
Intravenous Glycoprotein IIb/IIIa Inhibitor (Tirofiban) followed by Intra Arterial Urokinase and Mechanical Thrombolysis in Stroke
... GP IIb/IIIa inhibi- tors may prevent fibrin and platelet aggregates dep- osition triggered by the endothelial procoagulant re- sponse to flow reduction and leading to the collapse of microcirculation (the ...
7
Fibrinogen independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotein IIb IIIa complex at high shear rate
... Platelet adhesion and thrombus formation on subendothelium, studied at a shear rate of 2,600 s-1, were inhibited by two synthetic peptides known to interact with GPIIb-IIIa. One peptide (HHLGGAKQAGDV) corresponds ...
11
Independent modulation of von Willebrand factor and fibrinogen binding to the platelet membrane glycoprotein IIb/IIIa complex as demonstrated by monoclonal antibody
... monovalent Fab fragment of both LJP5 and LJP9 bound to unstimulated platelets in a saturable manner, but binding was markedly decreased after platelets had been incubated at 37 degrees C in the absence of added ...
10
Effects of monoclonal antibodies against the platelet glycoprotein IIb/IIIa complex on thrombosis and hemostasis in the baboon
... We have therefore used a baboon animal model to assess the effects of injected antibodies against platelet GP Ilb/IIIa with respect to the following variables: platelet count, bleeding t[r] ...
11
Platelet glycoprotein IIb/IIIa receptor blockade in coronary artery disease
... GP IIb/IIIa Receptor to Avoid Vascular Occlusion; CAPTURE = c7E3 Antiplatelet Therapy in Unstable Refractory Angina; EPIC = Evalua- tion of c7E3 for Prevention of Ischemic Complications; EPILOG = Evaluation ...
9
A variant of Glanzmann's thrombasthenia with abnormal glycoprotein IIb IIIa complexes in the platelet membrane
... example, after incubation with EDTA at room temperature, the patient's platelets bound little of the monoclonal antibodies AP-2 or T10 (anti-GP IIb-IIIa complex) although normally binding Tab (anti-GP ...
9
A new murine monoclonal antibody reports an activation dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex
... concentrations, 125I-10E5 bound nearly equally rapidly to both native and activated platelets, whereas 125I-7E3 bound slowly to native platelets and much more rapidly to activated platelets. This increased rate of 7E3 ...
9
Clinical Outcomes of Low Dose Methotrexate Therapy as a Second Line Drug for Intravenous Immunoglobulin Resistant Kawasaki Disease
... Thereby, IL and proinflammatory cytokines are reduced, and the activity of neutrophils and eosinophils is inhibited.22 Abciximab, a platelet glycoprotein IIb/IIIa receptor inhibitor, is [r] ...
6
Binding of fibrinogen to human monocytes
... glycoprotein IIb/IIIa complex (10E5) do not bind fibrinogen and have no procoagulant ...platelet glycoprotein IIb/IIIa ...
10
Plasminogen interacts with human platelets through two distinct mechanisms
... of glycoprotein IIb/IIIa (GPIIb/IIIa), showed minimal augmentation of plasminogen binding to thrombin-stimulated platelets but normal binding to unstimulated ...
10