Glycyrrhetinic acid
DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF GLYCYRRHETINIC ACID IN HYDROALCOHOLIC EXTRACT OF GLYCYRRHIZA GLABRA
... of Glycyrrhetinic acid in hydro-alcoholic extract of Glycyrrhiza glabra ...developed. Glycyrrhetinic acid show absorbance maximum at 254 nm when Phosphate Buffer ...of Glycyrrhetinic ...
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Efficient production of glycyrrhetinic acid in metabolically engineered Saccharomyces cerevisiae via an integrated strategy
... In this study, we produced glycyrrhetinic acid using the metabolic engineering of S. cerevisiae by introducing the entire heterogeneous biosynthetic pathway of GA. With the overexpression of ERG20, ERG9, ...
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EFFECT OF SOME GROWTH HORMONES AND COLCHICINE ON BIOMASS AND GLYCYRRHETINIC ACID PRODUCTION IN CALLUS CULTURE OF GLYCYRRHIZA GLABRA LINN
... β-acyl glycyrrhetinic acid from Glycyrrhiza glabra has been developed and the production is likely to be undertaken in near ...- glycyrrhetinic acid and its glycoside, ...
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Glycyrrhetinic Acid Induces Apoptosis in Leukemic HL60 Cells Through Upregulating of CD95/ CD178
... Many recent studies have focused on the potential application of natural products for treatment of cancers including leukemia. Recent findings have suggested that medicinal plants are valuable resources for production of ...
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Nasal Muco-ciliary transport time alteration: efficacy of 18 B Glycyrrhetinic acid
... nic acid is a specific medical compound that may be iso- lated from the licorice plant that binds selectively to HMGB1 protein released extracellularly and so inhibits its cytokine activities through a scavenger ...
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Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier
... a glycyrrhetinic acid-functionalized mesoporous silica nanoparticle (MSN-GA) was prepared for active tumor ...targeting. Glycyrrhetinic acid, a hepatocellular carcinoma-targeting group, was ...
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A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation
... Abstract: In this study, oxaliplatin (OX) liposomes surface-modified with glycyrrhetinic acid (GA) were developed by the film-dispersion method. Their morphology, physical and chemi- cal properties, and in ...
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Design, synthesis, and biological evaluation of the novel glycyrrhetinic acid-cinnamoyl hybrids as anti-tumor agents
... Conclusions: Compared with GA, target compounds demonstrated better anti-tumor activity, among which 8a was the most active one. What’s more, structure–activity relationship analysis also revealed that hybrids with trans ...
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ISOLATION AND ESTIMATION OF GLYCYRRHETINIC ACID FROM MARKETED ATHIMADHURAM CHURNA BY UV SPECTROPHOTOMETRY
... The optical characteristics such as absorption maxima, Beer’s law limits, molar absorptivity, slope (b), intercept (c), correlation coefficient (R 2 ), obtained from different concentrations, percent Relative Standard ...
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Synthesis, characterization, and in vitro evaluation of curcumin-loaded albumin nanoparticles surface-functionalized with glycyrrhetinic acid
... Abstract: We have designed and developed curcumin (Ccn)-loaded albumin nanoparticles (BNPs) surface-functionalized with glycyrrhetinic acid (Ccn-BNP-GA) for GA receptor- mediated targeting. Ccn-BNP-GA was ...
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Preparation of Glycyrrhetinic Acid Liposomes Using Lyophilization Monophase Solution Method: Preformulation, Optimization, and In Vitro Evaluation
... Glycyrrhetinic acid (GA), one kind of triterpene saponin, is mainly extracted from the roots of traditional Chinese medicine glycyrrhiza [1]. Studies have shown that GA has obvious antimicrobial, antiviral, ...
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18β-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: potential role of PPARγ and Nrf2 upregulation
... 18b-glycyrrhetinic acid (18b-GA), and 18a-GA (Montoro et ...cyrrhetinic acid protected mice against carbon tetrachloride (CCl 4 )-induced chronic liver ...
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Glycyrrhetinic acid-modified chitosan nanoparticles enhanced the effect of 5-fluorouracil in murine liver cancer model via regulatory T-cells
... Abstract: Modified chitosan nanoparticles are a promising platform for drug, such as 5-fluorouracil (5-FU), gene, and vaccine delivery. Here, we used chitosan and hepatoma cell- specific binding molecule ...
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18-beta-glycyrrhetinic Acid Protects against Staphylococcus aureus Infection by Regulating the NF-κB Pathway
... 18β-glycyrrhetinic acid (18β-GA) was obtained from Sigma-Aldrich (St. Louis, MO, USA) and dissolved in dimethyl sulfoxide (DMSO). Stock solutions were pre- pared at a concentration of 20 mg/ml and were ...
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Simultaneous quantification of gymnemagenin and 18β glycyrrhetinic acid in herbal drug formulation by validated RP HPLC method
... 18β-glycyrrhetinic acid. Marketed formulation was subjected to acid hydrolysis to obtain free form of 18β-glycyrrhetinic ...hydrochloric acid (100 mL) under reflux for 2 hours at 100° ...
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18β-glycyrrhetinic acid suppresses gastric cancer by activation of miR-149-3p-Wnt-1 signaling
... The major bioactive component in licorice root, 18β-glycyrrhetinic acid (GRA), exerts anti-inflammatory, anti-oxidative and anti-cancer effects [18–20]. Indeed, GRA is contained in the compound Hongdoushan ...
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Optimized synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and their characteristics
... Abstract: The nanoparticle drug delivery system, which uses natural or synthetic polymeric material as a carrier to deliver drugs to targeted tissues, has a broad prospect for clinical applica- tion for its targeting, ...
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In vitro and in vivo protein release and anti-ischemia/<br />reperfusion injury properties of bone morphogenetic protein-2-loaded glycyrrhetinic acid-poly(ethylene glycol)-b-poly(L-lysine) nanoparticles
... ga, glycyrrhetinic acid; hI/rI, hepatic ischemia/reperfusion injury; Ihh, Indian hedgehog; I/r, ischemia/reperfusion; Peg, poly(ethylene glycol); Pll, poly( l -lysine); shh, sonic hedgehog; sD, standard ...
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18 β glycyrrhetinic acid inhibits rotavirus replication in culture
... Licorice is derived from the root of the perennial herb Glycyrrhiza spp ., and in addition to its use as a sweeten- ing agent, has been one of the more extensively used medicinal plants [8]. Pharmacologically active ...
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ANTIDIABETIC ACTIVITY OF CAFFEIC ACID AND 18Î’ GLYCYRRHETINIC ACID AND ITS RELATIONSHIP WITH THE ANTIOXIDANT PROPERTY
... caffeic acid showed that the combined administration of 18β-glycyrrhetinic acid and caffeic acid to diabetic rats showed the levels of plasma glucose and insulin towards near normally when ...
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