glyoxalase-1
Original Article Up-regulation of the tumor promoter Glyoxalase-1 indicates poor prognosis in breast cancer
... Abstract: Glyoxalase 1 (Glo1) is an enzyme that plays a role to metabolize and inactivate methylglyoxal. Previous studies also have confirmed that Glo1 is closely related with tumorigenesis, metastasis, and ...
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Transcriptional control of glyoxalase 1 by Nrf2 provides a stress responsive defence against dicarbonyl glycation
... A functional antioxidant response element in exon-1 of human glyoxalase 1 gene We analysed the 5’-flanking region of the human GLO1 at locus 6p21.2 for the presence of stress response related ...
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Glyoxalase 1 copy number variation in patients with well differentiated gastroentero pancreatic neuroendocrine tumours (GEP NET)
... Glyoxalase 1 (Glo1) is part of the cytosolic glyoxalase system present in all human ...ca. 1 – 5% of protein and 1 in 10 5 nucleotides in DNA [3, 5, ...
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Glyoxalase 1 Prevents Chronic Hyperglycemia Induced Heart-Explant Derived Cell Dysfunction
... enzyme glyoxalase 1 (Glo1) restored the proangiogenic capacity of diabetic EDCs suggesting a means of reversing diabetic cell dysfunction by interfering with the accumulation of reactive ...
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Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin treated, apolipoprotein E deficient mice
... The reactive dicarbonyls, glyoxal and methylglyoxal (MG), increase in diabetes and may participate in the development of diabetic complications. Glyoxal and MG are detoxified by the sequential activities of ...
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Improved glycemic control and vascular function in overweight and obese subjects by glyoxalase 1 inducer formulation
... glyoxalase 1 (Glo1) – an enzyme that catalyses the metabolism of reactive metabolite and glycating agent, methylglyoxal – may improve metabolic and vascular ...
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The influence of glyoxalase 1 gene polymorphism on its expression at different stages of breast cancer in Egyptian women
... 23. Engelen L, Ferreira I, Brouwers O, Henry RMA, Dekker JM, Nijpels G, Heine RJ, Van Greevenbroek MMJ, Van Der Kallen C, Blaak EE, Feskens EJM, Ten Cate H, Stehouwer CDA, Schalkwijk CG. Polymorphisms in ...
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Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal
... Anxiety disorders, such as post-traumatic stress disorder, panic disorder, social phobia, specific phobia, and generalized anxiety disorder, comprise the most common psychiatric diseases in the United States (1). ...
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Characterization of Toxoplasma gondii glyoxalase 1 and evaluation of inhibitory effects of curcumin on the enzyme and parasite cultures
... mammalian glyoxalase 1 (Glo1) ...the glyoxalase system, as suggested by its inhibition of the enzymatic activities of Glo1 of the Trypanosoma and Plasmodium ...
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Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1 associated tumour multidrug resistance
... Two human tumour cell lines of relatively low Glo1 expression—NCI-H460 large cell lung carcinoma and A549 alveolar basal epithelial carcinoma, and two human tumour cell lines of relatively high Glo1 expres- sion—MG63 ...
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Characterisation of glyoxalase 1 mutant mouse and glyoxalase 1 copy number alteration
... and glyoxalase in mainstream glycolysis (Neuberg, ...the glyoxalase system that we know ...the glyoxalase system (Lohmann, ...the glyoxalase system (Jowett and Quastel, 1933) Yamazoye found ...
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Impairment of glyoxalase 1, an advanced glycation end product detoxifying enzyme, induced by inflammation in age related osteoarthritis
... Glo- 1 downregulation may involve NFκB. In vivo, the decrease in Glo-1 may be more important than ob- served in vitro because AGEs favor NFkB nuclear translocation and expression ...
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Multiple roles of glyoxalase 1 mediated suppression of methylglyoxal glycation in cancer biology—involvement in tumour suppression, tumour growth, multidrug resistance and target for chemotherapy
... to 1 h and remained at that level and MG adducts with RNA increased slowly throughout the initial 2 h period studied at very low ...ca. 1 mmol/mol arg MG-H1 ...
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Original Article Glyoxalase 1, regulated by LncRNA MALAT1, promotes malignant development of esophageal squamous cell carcinoma
... we performed target mRNAs screening using microarray chip, and the result showed that GLO1 is the most significantly changed mRNA upon MALAT1 knockdown in ECA109 (Table 1). More detailed result of the ...
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Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease
... On the day of termination, blood was collected from the hepatic portal vein and the heart and liver were excised and perfused with phosphate-buffered saline (PBS) until the majority of the blood was cleared. The heart ...
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Reappraisal of putative glyoxalase 1 deficient mouse and dicarbonyl stress on embryonic stem cells in vitro
... 42 μM (N = 15) - Figure 4a. In addition, cell viability of mESCs decreased with > 50 μM MG under 20% oxygen growth conditions – Figure 4b, suggesting the inhibition of cell growth by MG is due to both growth arrest ...
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Glyoxalase 1 modulation in obesity and diabetes
... activity of Glo1 will decrease proportionately and local concentration of MG thereby increases (1). The pentosephosphate pathway is also activated to produce increased flux of NADPH to sustain NADPH oxidase ...
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A GLYOXALASE-1 VARIANT ASSOCIATED WITH THE t-COMPLEX IN HOUSE MICE
... GLO- 1 phenotypes among progeny of various backcrosses did not provide any evidence that loci unlinked to the t-haplotype determined GLO- 1C (Table 3). T h e GLO-1 ph[r] ...
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Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics
... The glyoxalase system in the cytoplasm of cells provides the primary defence against dicarbonyl glycation by catalysing the metabolism of MG and related reactive ...in glyoxalase 1 (Glo-1) ...
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Bioinformatics Study of the Sequence Analysis and Secondary Structure Prediction of Avicennia marina glyoxalase I protein
... marina glyoxalase I (Q9AXH1_AVIMR) has shown that the major part of this polypeptide consists of hydrophobic ...marina glyoxalase I retrieved from ProtParam (Gasteiger et ...marina glyoxalase I has ...
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