Glypican-3
Original Article Immunohistochemical expression of glypican 3 in endometrial carcinoma and correlation with prognostic parameters
... revealed Glypican 3 expression in ...between Glypican 3 expression and prog- nostic factors in endometrial ...found Glypican 3 to be significantly associated with poor prognostic ...
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Diagnostic performance of alpha-fetoprotein, lens culinaris agglutinin-reactive alpha-fetoprotein, des-gamma carboxyprothrombin, and glypican-3 for the detection of hepatocellular carcinoma: a systematic review and meta-analysis protocol
... Glypican-3 (GPC-3) is a heparin sulfate proteoglycan that interacts with several growth factors by binding to the cell membrane via glycosylphosphatidylinositol anchors [31,32]. Because GPC-3 ...
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Role of Serum Glypican 3 in the Diagnosis of Hepatocellular Carcinoma in the Upper Egypt
... Background and Aim: Early diagnosis of hepatocellular carcinoma (HCC) is essential for achieving good prognosis. Glypican 3 (GPC3) has been reported to be raised in HCC in comparison with non-neoplastic ...
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Original Article HCRP1, ID4 and Glypican-3: an optimal panel of biomarkers for diagnosis of hepatocellular carcinoma
... and Glypican-3 (GPC-3) was performed in 98 cases of HCCs, 15 large regenerative nodules arising in cirrhotic livers, 12 hepatocellular adenomas (HCA), 10 focal nodular hyperplasias (FNH), and 20 ...
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Original Article Value of the combined detection arginase-1 and glypican-3 expression in distinguishing hepatocellular carcinoma from metastatic tumors
... and glypican-3 (GPC-3) was separately specific markers for HCC, how- ever, the value of Arginase-1-Glypican-3 (Arg1-GPC3) combined staining in distinguishing hepatocellular carcinoma ...
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Intratumoral reciprocal expression of monocarboxylate transporter 4 and glypican 3 in hepatocellular carcinomas
... Liver cancer is the leading cause of cancer death world- wide and is the second leading cause of cancer death in men [1]. As hepatocellular carcinoma (HCC) is the most common liver malignancy, the molecular mechanism of ...
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Glypican-3 induces a mesenchymal to epithelial transition in human breast cancer cells
... Glypican-3 (GPC3), a proteoglycan involved in the regulation of proliferation and survival, has been associated with cancer. In this study we observed that the expression of GPC3 is opposite to the ...
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Evaluating clinical and prognostic implications of Glypican-3 in hepatocellular carcinoma
... CEA (pCEA), MOC-31, CD10, and α-fetoprotein (AFP), have been used to differentiate HCC from other tumors and to evaluate prognosis [4–18]. Glypican 3 and HepPar1, for example, are useful in distinguishing ...
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Development and Validation of a Two-Site Immunoradiometric assay for Glypican-3 in plasma: Implication in Diagnosis of Hepatocellular Carcinoma
... Glypican-3 (GPC3) belongs to the heparan sulfate proteoglycan family. It is a cell surface protein which could be cleaved off to release a soluble 40-KDa fragment that can be detected in blood. GPC3 is ...
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EXPRESSION OF GLYPICAN-3(GPC-3) AND 8-HYDROXYDEOXYGUANOSINE (8-OHDG) IN CHRONIC HEPATITIS C AND RELATIONSHIP WITH HEPATOCELLULAR CARCINOMA
... antibodies: Glypican- 3(GPC-3): Mouse monoclonal antibody, Dilution 1:100; (CM396, A,B, Clone IG12, Biocare Medical LLC, Concord, USA); 8- Hydroxydeoxyguanosine(8-OHdG): Monoclonal antibody, ...
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Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer
... that Glypican-3 (GPC3) is absent in invasive tumors and metastatic lymph nodes, in particular in aggressive and highly disseminated signet ring cell ...
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Influence of Glypican-3 as a Newly Diagnostic Biomarker in Early Detection of Hepatocellular Carcinoma Among Saudi Patients
... serum Glypican-3 and AFP levels has been detected as HCC after 6 months of follow ...that Glypican-3 could be used for screening and early diagnosis of HCC among CLC ...
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Can glypican-3 be a disease-specific biomarker?
... more significantly in patients with severe pneumonia accompanied with ARDS than those with severe pneu- monia alone [3]. We proposed that the circulating level of glypican-3 may correlate with the ...
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Expression of glypican 3 in placental site trophoblastic tumor
... Background: Glypican-3 (GPC3) is a membrane-bound heparan sulfate proteoglycan that functions in embryonic cell growth and differentiation and is highly expressed in the ...
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Expression of Glypican 3 in low and high grade urothelial carcinomas
... Background: Glypican-3 (GPC3) is an oncofetal protein which is encoded by GPC3 gene and takes role in the regulation of cell division and apoptosis. Overexpression of GPC3 has been reported in some types of ...
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Generation of functional CD8+ T Cells by human dendritic cells expressing glypican-3 epitopes
... The yield of each SP6 mMessage Machine reaction was around 20 μg of capped mRNA from 1 μg of linear DNA template. Transcripts were extracted using RNAeasy col- umns and the quality of the mRNA confirmed by dena- turing ...
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Glypican-3-targeted precision diagnosis of hepatocellular carcinoma on clinical sections with a supramolecular 2D imaging probe
... (including glypican-1 [GPC-1], glypican-5 [GPC-5], golgi membrane protein-1 [GOLM-1] and dickkopf-like-1 protein [DKK-1]) were over-expressed in a human embryonic kidney cell line (HEK293T) through the ...
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Autophagy suppresses proliferation of HepG2 cells via inhibiting glypican-3/wnt/β-catenin signaling
... by 3-methyl adenine (3-MA) could rescue rapamycin-directed downregulation of GPC3 and wnt/β-catenin target genes and aug- ment the proliferation of HepG2 ...attenuated 3-MA stimulation of HepG2 cell ...
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Expression of oncofetal antigen glypican-3 associates significantly with poor prognosis in HBV-related hepatocellular carcinoma
... Hepatic GPC-3 expressions and its cellular distribution in cancerous-, their matched surrounding-, or distal cancerous tissues analyzed by tissue microarrays with immunohistochemistry using anti-human GPC-3 ...
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Glypicans: proteoglycans with a surprise
... that glypican-3 (GPC3) is mutated in an overgrowth and dysmorphic ...this glypican may interact with signaling pathways that have not been tradi- tionally associated with membrane-bound ...
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