Glypican-3(GPC-3)
Original Article HCRP1, ID4 and Glypican-3: an optimal panel of biomarkers for diagnosis of hepatocellular carcinoma
... and Glypican-3 (GPC-3) was performed in 98 cases of HCCs, 15 large regenerative nodules arising in cirrhotic livers, 12 hepatocellular adenomas (HCA), 10 focal nodular hyperplasias (FNH), and ...
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Influence of Glypican-3 as a Newly Diagnostic Biomarker in Early Detection of Hepatocellular Carcinoma Among Saudi Patients
... mRNA Glypican-3 (GPC-3) as newly identified diagnostic and prognostic biomarkers for HCC between study ...serum GPC-3 (sGPC-3) bySandwich ELISA. Glypican-3 ...
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Diagnostic performance of alpha-fetoprotein, lens culinaris agglutinin-reactive alpha-fetoprotein, des-gamma carboxyprothrombin, and glypican-3 for the detection of hepatocellular carcinoma: a systematic review and meta-analysis protocol
... and glypican-3 (GPC-3) have been widely investigated as diagnostic biomarkers for early-stage HCC in at-risk ...and GPC-3 for the detection of HCC, particularly early-stage ...
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Original Article Value of the combined detection arginase-1 and glypican-3 expression in distinguishing hepatocellular carcinoma from metastatic tumors
... and glypican-3 (GPC-3) was separately specific markers for HCC, how- ever, the value of Arginase-1-Glypican-3 (Arg1-GPC3) combined staining in distinguishing hepatocellular ...
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EXPRESSION OF GLYPICAN-3(GPC-3) AND 8-HYDROXYDEOXYGUANOSINE (8-OHDG) IN CHRONIC HEPATITIS C AND RELATIONSHIP WITH HEPATOCELLULAR CARCINOMA
... Background: In Egypt, hepatocellular carcinoma (HCC) is the second most common cancer in men and the 6th most common cancer in women. Egypt has the highest prevalence of HCV in the world and the prevalence of HCC is ...
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Expression of Glypican 3 in low and high grade urothelial carcinomas
... Background: Glypican-3 (GPC3) is an oncofetal protein which is encoded by GPC3 gene and takes role in the regulation of cell division and apoptosis. Overexpression of GPC3 has been reported in some types of ...
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Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer
... that Glypican-3 (GPC3) is absent in invasive tumors and metastatic lymph nodes, in particular in aggressive and highly disseminated signet ring cell ...
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Role of Serum Glypican 3 in the Diagnosis of Hepatocellular Carcinoma in the Upper Egypt
... Background and Aim: Early diagnosis of hepatocellular carcinoma (HCC) is essential for achieving good prognosis. Glypican 3 (GPC3) has been reported to be raised in HCC in comparison with non-neoplastic ...
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Intratumoral reciprocal expression of monocarboxylate transporter 4 and glypican 3 in hepatocellular carcinomas
... Liver cancer is the leading cause of cancer death world- wide and is the second leading cause of cancer death in men [1]. As hepatocellular carcinoma (HCC) is the most common liver malignancy, the molecular mechanism of ...
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Glypican-3 induces a mesenchymal to epithelial transition in human breast cancer cells
... Glypican-3 (GPC3), a proteoglycan involved in the regulation of proliferation and survival, has been associated with cancer. In this study we observed that the expression of GPC3 is opposite to the ...
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Evaluating clinical and prognostic implications of Glypican-3 in hepatocellular carcinoma
... We retrieved the patients’ paraffin-embedded tissue specimens Unstained sections, and IHC was performed at Ventana Medical Systems, Inc. (VMSI, Tucson, AZ). IHC procedures for GPC3, including antigen recovery, antibody ...
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Original Article Immunohistochemical expression of glypican 3 in endometrial carcinoma and correlation with prognostic parameters
... ican 3 mouse monoclonal antibody (1:200, clone IG 12, Cell Marque, Burlington, VT, ...Finally, 3, 3-diaminobenzidine as the substrate or chromogen was used to form an insoluble brown ...
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Development and Validation of a Two-Site Immunoradiometric assay for Glypican-3 in plasma: Implication in Diagnosis of Hepatocellular Carcinoma
... Glypican-3 (GPC3) belongs to the heparan sulfate proteoglycan family. It is a cell surface protein which could be cleaved off to release a soluble 40-KDa fragment that can be detected in blood. GPC3 is ...
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Can glypican-3 be a disease-specific biomarker?
... (50%), glypican-3 (45.7%), and S100A7 (45.7%). Desmocollin-3 was the most specific marker for poorly differentiated squamous cell lung carcinoma (100%), followed by CK5/6 ...(98.3%), ...
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Expression of glypican 3 in placental site trophoblastic tumor
... Background: Glypican-3 (GPC3) is a membrane-bound heparan sulfate proteoglycan that functions in embryonic cell growth and differentiation and is highly expressed in the ...
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Generation of functional CD8+ T Cells by human dendritic cells expressing glypican-3 epitopes
... the 3' untranslated region of the human α-globin gene, to increase the intracellular stability of mRNA transcripts [22], was inserted between the Sac1 and Sph1 ...either GPC-3 or enhanced green ...
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Glypican-3-targeted precision diagnosis of hepatocellular carcinoma on clinical sections with a supramolecular 2D imaging probe
... Results: We show that the 2D imaging probe developed with minimal background fluorescence can sensitively and selectively image cells overexpressing GPC-3 over a range of control cells expressing other ...
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Expression of oncofetal antigen glypican-3 associates significantly with poor prognosis in HBV-related hepatocellular carcinoma
... Hepatic GPC-3 expressions and its cellular distribution in cancerous-, their matched surrounding-, or distal cancerous tissues analyzed by tissue microarrays with immunohistochemistry using anti-human ...
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Autophagy suppresses proliferation of HepG2 cells via inhibiting glypican-3/wnt/β-catenin signaling
... by 3-methyl adenine (3-MA) could rescue rapamycin-directed downregulation of GPC3 and wnt/β-catenin target genes and aug- ment the proliferation of HepG2 ...attenuated 3-MA stimulation of HepG2 cell ...
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GPC-3 in hepatocellular carcinoma: current perspectives
... Abstract: Glypican-3 (GPC3), a member of heparan sulfate proteoglycans, attaches to the cell membrane and is frequently observed to be elevated in hepatocellular carcinoma ...of GPC-3 in serum ...
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