Graft-vs.-Host Disease
Ruxolitinib in steroid refractory graft-vs.-host disease: a case report
... malignancies. Graft-vs.-host disease (GvHD) remains a life-threatening ...the host inflammatory response governed by several kinase families, including Janus kinases (JAK) ...
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Specificity of T cells invading the skin during acute graft vs host disease after semiallogeneic bone marrow transplantation
... The mechanisms responsible for skin lesions during acute graft-vs.-host disease (aGVHD) after allogeneic bone marrow transplantation (BMT) are poorly understood. The exact role of various ...
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Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft vs host disease
... In vivo administration of antibody to the ligand for CD40, gp39, blocked cGVHD-induced serum anti-DNA autoantibodies, IgE production, spontaneous immunoglobulin production in vitro, and [r] ...
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Minimal residual disease- and graft-vs.-host disease-guided multiple consolidation chemotherapy and donor lymphocyte infusion prevent second acute leukemia relapse after allotransplant
... due to the application of immunosuppressive agents for 2–4 weeks in patients receiving DLI from HLA-identical related donors and for 6 weeks in patients receiving DLI from haploidentical related donors or unrelated ...
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Effector mechanisms in Graft-vs-Host Disease in response to minor Histocompatibility antigens. I. Absence of correlation with cytotoxic effector cells.
... To test the possibility that the failure to detect antihost Tc cells shortly after grafting as observed in several patients might reflect a general Tc cell impairment (as a result of inc[r] ...
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Probable Graft-vs-Graft Reaction in an Infant After Exchange Transfusion and Marrow Transplantation
... Graft-vs-Host Disease Following Exchange Transfusion and Before Bone Marrow Transplantation.. Serologically Blood HLA Type.[r] ...
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<p>Role of Stem-Cell Transplantation in Leukemia Treatment</p>
... Abstract: Stem cells (SCs) play a major role in advanced fields of regenerative medicine and other research areas. They are involved in the regeneration of damaged tissue or cells, due to their self-renewal ...
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What's New in Pediatric Surgery—1989
... Cnombleholme et al’5 reported the role of T cells on engraftment and graft vs host disease in an in utero model.. Hematopoietic stem cells were trans- planted from adult sheep into fetal[r] ...
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Recognition of a B cell leukemia associated minor histocompatibility antigen by cytotoxic T lymphocytes.
... Abbreviations used in this paper: mHag, minor histocompatibility antigen; BMT, bone marrow transplantation; CVHD, graft-vs-host disease; GVL, grafl-vs- leukemia; B-ALL, B-[r] ...
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Mesenchymal stromal cells for the prophylaxis and treatment of graft-versus-host disease—a meta-analysis
... Additional file 1: Figure S1. Risk of Bias. Figure S2. Overall survival of MSC and control patients. Figure S3. Overall survival at last follow-up. Figure S4. aGvHD incidence for patients from the MSC group compared to ...
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Pathophysiology, prevention, and treatment of acute graft-versus-host disease
... Several strategies involving organ protection have been stud- ied to reduce the incidence of aGVHD. The Nordic group reported a prospective, randomized trial on the addition of ursodeoxycholic acid (UDCA) to their ...
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Cytokine mediators of chronic graft versus host disease
... We thank members of our laboratories, our collaborators, and the scientific community for providing the foundation for this Review. We apologize to those investigators whose work we were unable to cite because of space ...
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Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems
... Current models suggest ROS generated by immune cell responses induce DNA single and double-stranded breaks or modify DNA bases by forming adducts (Figure 1a). Th e major forms of oxidative DNA damage are nonbulky lesions ...
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Social preferences for health states associated with acute myeloid leukemia for patients undergoing treatment in the United Kingdom
... The disease is no better, and you have been told you have no further treatment ...your disease are returning, including fatigue, loss of appetite, and ...
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Ex vivo and in vivo T cell-depleted allogeneic stem cell transplantation in patients with acute myeloid leukemia in first complete remission resulted in similar overall survival: on behalf of the ALWP of the EBMT and the MSKCC
... Results: Two-year overall survival estimate was 69.9% (95% CI, 58.5 – 69.4) in the ATG group and 67.6% (95% CI, 60.3 – 74.9) in the CD34+ group ( p = 0.31). The cumulative incidence of grade II – IV acute GVHD and ...
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Bilateral corneal ulceration in ocular graft-versus-host disease
... Purpose: To report on corneal ulceration in ocular graft-versus-host disease (GVHD). Methods: This was a retrospective, observational case series investigating corneal ulceration and perforation in a ...
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Correlation of T-Cell Subsets and Hypercholesterolemia of the Donor and Its Association with Acute Graft-versus-Host Disease
... preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow ...the graft and the risk of acute graft-versus-host disease ...
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Novel regulatory therapies for prevention of Graft-versus-host disease
... without graft rejection and ...inhibiting graft-versus-host reactions and selectively eliminating activated T cells in response to donor antigens in minor histocompatibility disparity [38] and ...
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Graft versus host disease and microchimerism in a JAK3 deficient patient
... T-A cloning of PCR fragments in the pGEM vector was performed, as described previously [10], to evaluate the probability of masaicism or microchimerism. We used E. coli Top10 as host cells, and tetracycline ...
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The paranasal sinuses of patients with acute graft versus host disease
... the host marrow, allowing more intensive antineoplastic ...acute graft- versus-host disease (AGVHD), occurs because the transplanted immunocompetent T cells rec- ognize host antigens as ...
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