Granulocyte colony-stimulating factor receptor
Increased granulocyte colony stimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony stimulating factor receptor mutation derived from a patient with severe congenital neutropenia
... the granulocyte colony-stimulating factor receptor (G-CSFR) in the pathogenesis of severe con- genital neutropenia (SCN) and the subsequent development of acute myeloid leukemia (AML) ...
11
A functional granulocyte colony stimulating factor receptor is required for normal chemoattractant induced neutrophil activation
... stantial evidence suggests that, in addition to promoting PMN production, G-CSF may play a significant role in regulating mature PMN functions, including CD11b (6–8) and FcγR1 (9–11) expression, degranulation (12, 13), ...
9
Granulocyte-Colony Stimulating Factor Receptor, Tissue Factor, and VEGF-R Bound VEGF in Human Breast Cancer In Loco
... with minimal background staining. Controls con- sisted of omission of the primary antibodies from the procedure. The results of staining the breast cancer tissues were compared with respective healthy tissues and were ...
7
Tumor necrosis factor downregulates granulocyte colony stimulating factor receptor expression on human acute myeloid leukemia cells and granulocytes
... G-CSF receptor numbers on purified blood granulocytes are also downmodulated by ...G-CSF receptor expression becomes evident within 10 min after incubation of the cells with TNF at 37 degrees C and is not ...
5
Leukemoid reaction and autocrine growth of bladder cancer induced by paraneoplastic production of granulocyte colony stimulating factor – a potential neoplastic marker: a case report and review of the literature
... Introduction: Granulocyte colony-stimulating factor produced by nonhematopoietic malignant cells is able to induce a leukemoid reaction by excessive stimulation of leukocyte ...of ...
6
Spotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date
... that granulocyte-macrophage colony-stimulating factor (GM-CSF), known to be a hematopoietic factor, is also one of the proinflammatory cytokines involved in macrophage activation, ...
13
The expression and regulation of the granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR)
... The JAK family of tyrosine kinases are thought to be activated by ligand- induced dimerization (hetero or homo) of cytokine receptor chains. This brings about local aggregation of the JAKs, resulting in their ...
201
Different effects of granulocyte colony-stimulating factor and erythropoietin on erythropoiesis
... forming cell experiment, G-CSF exhibited erythropoietic properties only when used with EPO [18]. This finding im- plied that G-CSF was unable to stimulate erythropoiesis without EPO. The EPOR is expressed dominantly on ...
9
A study of the granulocyte-macrophage colony stimulating factor receptor (GM-CSFR) in leukaemia
... the factor IX gene in haemophilia, have determined that the optimum size of PCR product is between 200 and 400 base pairs (bp) [Hayashi et al, 1991, Glavac et al, ...
176
Granulocyte Colony-Stimulating Factor Serum and Urine Concentrations in Neutropenic Neonates Before and After Intravenous Administration of Recombinant Granulocyte Colony-Stimulating Factor
... One aspect of our study, not previously encoun- tered in rG-CSF pharmacokinetic studies, was the extremely high pre-first-dose G-CSF serum and urine concentrations in our neutropenic neonates with sepsis and shock. The ...
8
Expression and function of the granulocyte-macrophage colony-stimulating factor receptor durning myeloid differentiation
... Previous studies indicate that the GM-CSF R consists of a ligand binding a chain and a p chain which is not only required for high-affinity binding but is crucial for signal transduction (Kitamura and Miyajima, 1992; ...
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Granulocyte colony stimulating factor (G CSF) and granulocyte macrophage colony stimulating factor (GM CSF) for sepsis: a meta analysis
... Toll-like receptor-4- and Toll-like receptor-2-induced cytokine production, and reduced time of mechanical ventilation as well as length of hospital and intensive care unit ...
12
Combination systemic therapies with immune checkpoint inhibitors in pancreatic cancer: overcoming resistance to single-agent checkpoint blockade
... antigen receptor; CCK: cholecystokinin; CSF1: colony-stimulating factor 1; CSF1R: colony-stimulating factor 1 receptor; CR: complete response; CTLA-4: cytotoxic ...
16
Myeloid-derived suppressor cells in hematological malignancies: friends or foes
... G-CSF: Granulocyte colony- stimulating factor; GM-CSF: Granulocyte-macrophage colony-stimulating fac- tor; G-PBSC: G-CSF peripheral blood stem cells harvest; GRFS: GVHD ...
12
Bone marrow drives central nervous system regeneration after radiation injury
... a granulocyte-colony stimulating factor (G-CSF) receptor knockout mouse model in combination with bone marrow cell transplantation, MRI, and neurocognitive functional assessments, we ...
14
Granulocyte colony stimulating factor producing rectal cancer
... that granulocyte-macrophage colony stimu- lating factor (GM-CSF) secretion was also detected by human colorectal cancer specimens and cell lines ...its receptor occur in over 90% of pri- mary ...
5
The role of chromatin in the transcriptional regulation of the human T-cell leukemia virus type 1
... XVll ER estrogen receptor ESAI essential SAS2-related acetyltransferase Exoill Exonuclease III g relative centrifugal force GM-CSF Granulocyte macrophage-colony stimulating factor GR glu[r] ...
268
Identification of a functional receptor for granulocyte colony stimulating factor on platelets
... Furthermore, the augmented ADP-induced secondary aggregation of platelets on G-CSF receptors was completely abrogated in the presence of anti-G-CSF polyclonal antibodies.. These results [r] ...
5
Neutrophils in traumatic brain injury (TBI): friend or foe?
... as granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage-colony stimulating factor (GM- CSF) [11], or external stimuli including stress, trauma, ...
18
Isoforms of the granulocyte-macrophage colony-stimulating factor receptor
... the receptor binds GM-CSF with the expected low affinity but with approximately 10% of the binding sites compared to the main GM-CSFRa ...affinity receptor when co-expressed with pc rather than the expected ...
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