Graves' ophthalmopathy
Human placenta-derived mesenchymal stem cells ameliorate orbital adipogenesis in female mice models of Graves’ ophthalmopathy
... Background: Graves ’ ophthalmopathy (GO) is a complication of Graves ’ disease (GD), in which orbital connective tissues become inflamed and increase in volume and orbital fibroblasts within the ...
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Extraocular muscle repositioning as the last therapeutic option for a patient with a severe course of Graves’ Ophthalmopathy: a case report
... Background: Graves ’ disease is a common autoimmune inflammatory condition of the thyroid. About one in four of affected patients also develop orbital symptoms like exophthalmos, proptosis and diplopia - called ...
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Orbital positron emission tomography/computed tomography (PET/CT) imaging findings in graves ophthalmopathy
... GO: Graves ophthalmopathy; 18-FDG: 18-Fluorodeoxiglucose; SUVmax: Maximum standardized uptake value; VISA: Vision, inflammation, strabismus and appearance; TSH: Thyroid-stimulating hormone; IGF-1R: Insulin ...
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Calsequestrin is Decreased in the Thyroid Gland of Patients with Graves’ Disease – Further Evidence for a Role of Autoimmunity against this Protein in Graves’ Ophthalmopathy
... of ophthalmopathy they are not specific to GO, being detected in about 10% of apparently normal subjects and in some patients with other forms of skeletal muscle damage or inflammation ...in Graves’ ...with ...
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Retrobulbar T cells from patients with Graves' ophthalmopathy are CD8+ and specifically recognize autologous fibroblasts
... Graves' ophthalmopathy is an autoimmune condition characterized by T cell infiltration of the retrobulbar ...severe Graves' ophthalmopathy undergoing orbital decompression surgery, and six T ...
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Pathophysiology of Graves’ Ophthalmopathy: A Literature Review
... Graves’ ophthalmopathy (GO), an autoimmune condition associated with Graves’ disease (GD), occurs at a prevalence of nearly 40% in patients diag- nosed with ...
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Graves Ophthalmopathy: The Bony Orbit in Optic Neuropathy, Its Apical Angular Capacity, and Impact on Prediction of Risk
... proved Graves ophthalmopathy who were referred to a sin- gle ophthalmologist in the oculoplastic service of a tertiary referral eye center during a 5-year period were collected and ...for Graves ...
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Effect of Intravenous Methylprednisolone on the Signs & Symptoms of Graves’ Ophthalmopathy
... Graves’ ophthalmopathy (GO) is the most frequent extrathyroidal manifestation of Graves’ disease (GD) and develops in 25% to 50% of ...the ophthalmopathy is mostly associated with ...
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Total thyroidectomy (Tx) versus thionamides (antithyroid drugs) in patients with moderate to severe Graves’ ophthalmopathy – a 1 year follow up: study protocol for a randomized controlled trial
... Background: Graves ’ disease (GD) is characterized by thyrotoxicosis and goiter and arises through circulating autoantibodies that bind to, and stimulate, the thyroid hormone receptor ...of ophthalmopathy, ...
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Olfactory Neuroblastoma (Esthesioneuroblastoma) following Retro-Orbital Irradiation for Graves’ Ophthalmopathy Tamjid B *1 , Cher L 1, Wada M2 , Kalnins R 3and Gan H1
... A 48 year old male presented with a two month history of occasional headaches, left nostril epistaxis, blocked nose and loss of sense of smell in December 2000. His past medical history included hyperthyroidism and ...
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Persistent hyperthyroidism and de novo Graves’ ophthalmopathy after total thyroidectomy
... She presented in May 2013 with worsening fatigability as well as generalized weakness, which was diagnosed as a myasthenic flare. Further history revealed weight loss, palpitations, heat intolerance and reduced menstrual ...
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Thyroid antibody-negative euthyroid Graves’ ophthalmopathy
... of Graves’ disease, present in nearly all patients with the ...Euthyroid Graves’ ophthalmopathy (EGO) is a well-recognized clinical entity, but its occurrence in patients with negative TRAbs is a ...
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Association of IL12B polymorphisms with susceptibility to Graves ophthalmopathy in a Taiwan Chinese population
... Graves ophthalmopathy (GO) is a type of fibroprolifera- tive autoimmune disease, which is characterized by inflammation, remodeling, and expansion of the retroo- cular fibroblasts of the ...with ...
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Association of TLR7 and TSHR copy number variation with Graves’ disease and Graves’ ophthalmopathy in Chinese population in Taiwan
... The participants in this study were 196 healthy controls and 484 GD patients which including 203 of them with ophthalmopathy (GO) recruited from China Medical University Hospital in Taiwan. All GD patients were ...
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The influence of hepatitis C infection and interferon-α therapy on thyrotropin blocking and stimulating autoantibodies in Graves' ophthalmopathy: a case report
... Hepatitis C virus is a highly immunogenic pathogen often inducing autoimmune activation changes and this can often be further exacerbated by interferon therapy. As HCV is lymphocytotropic, it can modulate T cell and B ...
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Development and psychometric properties of the Thai Graves’ ophthalmopathy quality of life (GO-QOL) questionnaire
... The first GO-specific questionnaire (GO-QOL) was developed in 1998 by Terwee et al. [4]. It contained 16 questions, 8 on visual functioning and 8 on appearance. The study showed that the GO-QOL demonstrated good ...
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Novel single-nucleotide polymorphisms in the calsequestrin-1 gene are associated with Graves’ ophthalmopathy and Hashimoto’s thyroiditis
... with Graves’ disease, called Graves’ ophthalmopathy (GO), greatly reduces the quality of life in affected ...GO, Graves’ hyperthyroidism (GH), or Hashimoto’s thyroiditis (HT) and control ...
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Long-term follow-up of seven patients with ophthalmopathy not associated with thyroid autoimmunity: heterogeneity of autoimmune ophthalmopathy
... congestive ophthalmopathy who was studied intensely, collagen XIII antibodies were initially positive and then became negative as the eye disease stabilized, while antibodies targeting calsequestrin were always ...
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A characteristic optic disc appearance associated with myopia in subjects with Graves' ophthalmopathy and in subjects with primary open-angle glaucoma
... to Graves’ ophthalmopathy; (5) proptosis, if present, was not sufficiently severe to be indicative for orbital decompression ...of Graves’ eye disease), 15 patients with categories 2b, 2c, 5b, 5c, ...
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Update on the medical treatment of Graves’ ophthalmopathy
... Graves’ disease and Graves’ ophthalmopathy are chronic disease processes with both physical and psychological manifestations. Education plays an important role to help with understanding patient ...
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