Growth factor receptors
Role of vascular endothelial growth factor receptors in the pathogenesis of psoriasis
... endothelial growth factor receptors (VEGFRs, including VEGFR-1, VEGFR-2 and VEGFR-3) were found to be expressed in normal human epidermis and associated with proliferation and migration of ...
6
Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer
... kinase growth factor receptors presents one of the most common oncogenic events in ...these receptors is a proven therapeutic strategy, as exemplifi ed by the effi cacy of trastuzumab in HER2 ...
9
Molecular docking and interactions of pueraria tuberosa with vascular endothelial growth factor receptors
... endothelial growth factor receptors: Vascular endothelial growth factor receptor‑1 and vascular endothelial growth factor receptor‑2, major factors responsible for ...
7
Tumor-induced osteomalacia due to a recurrent mesenchymal tumor overexpressing several growth factor receptors
... of growth factor receptors implicated in tumor angiogenesis and metastatic potential (platelet derived growth factor type A (PDGFRA), PDGFRB and vascular endothelial growth ...
6
Ionic signalling by growth factor receptors
... In recent years much has been learned about the various molecular events that are induced by growth factor-receptor interaction. There is good evidence that both ionic events are the dir[r] ...
16
Fibroblast growth factor receptors and skeletogenesis
... 1.1.4 Developm ent of the skull The skull of vertebrates consists of bones of both membranous and cartilaginous origins. The calvaria is principally composed of two frontal bones, two parietal bones and an interparietal ...
219
Colocalization of somatostatin receptors and epidermal growth factor receptors in breast cancer cells
... of receptors for insulin-like growth factor 1, somatostatin, and epidermal ...Somatostatin receptors in primary human breast can- cer: quantitative analysis of mRNA for subtypes 1-5 and ...
19
Sensitization of epithelial growth factor receptors by nicotine exposure to promote breast cancer cell growth
... aberrant growth signaling plays an important role in the perturbation of growth restriction and cell cycle ...includes growth factors, kinases, phosphatases as well as extracellular matrix ...
11
Sensitization of Epithelial Growth Factor Receptors by Nicotine Exposure to Promote Breast Cancer Cell Growth
... nAChR, via Src, activates EGFR-dependent or -independent downstream pathways following nicotine treatment Since c-Src, Akt, and ERK1/2 in the cells were activated after nicotine treatment, it was possible that these ...
12
CiteSeerX — REVIEW eph, the largest known family of putative growth factor receptors
... Using these antibodies the CekS protein was found to have an apparent molecular mass of 120 kDa and its pattern of expression in the 10 day chicken embryo, determined by Western blotting[r] ...
5
Fibroblast Growth Factor Receptors Function Redundantly During Zebrafish Embryonic Development
... Fibroblast growth factor (Fgf) signaling regulates many processes during ...multiple receptors are involved in coordinating most Fgf-dependent developmental ...
19
Current Status of Fibroblast Growth Factor Receptors Targeted Therapies in Breast Cancer
... FGFRs activating mutations In the context of FGFR-driven tumour formation, although its gene amplifications are the most common type of alterations leading to BC, there are some evidences showing that activating ...
29
The relationship between oestrogen and epidermal growth factor receptors in human breast cancer
... The investigation was approached in two original ways. Firstly, we developed a dual immunocytochemical assay which is able to stain for both ER and EGFR on a single 5 pm frozen section sample of breast cancer. This assay ...
259
Frequency and types of mutations of epidermal growth factor receptors in invasive lung adenocarcinomas
... Iako je inicijalna dijagnoza invazivnog adenokarcinoma u ovom istraţivanju postavljena u biopsijskim uzorcima odnos izmeĊu TTF-1 ekspresije i EGFR mutacionog statusa [r] ...
139
Adenovirus E4-ORF1 Dysregulates Epidermal Growth Factor and Insulin/Insulin-Like Growth Factor Receptors To Mediate Constitutive Myc Expression
... IMPORTANCE While human adenoviruses primarily produce self-limited acute infections in humans, these agents are associated with life- threatening diseases in immunocompromised patients and in otherwise healthy ...
12
Human squamous cell lung cancers express increased epidermal growth factor receptors
... Epidermal growth factor (EGF) promotes the growth of cultured benign and malignant cells. Recent studies have demonstrated that the amount of EGF receptor is elevated in squamous cell carcinoma cells ...
6
Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor alpha in cultured human vascular endothelial cells
... after 24 h. TNF- a treatment did not significantly affect the KDR/flk-1 half-life but did decrease its rate of transcription to 40% of control. The decrease in KDR/flk-1 mRNA de- pended partially on new protein synthesis ...
8
Down Regulation of Epidermal Growth Factor Receptors : Direct Demonstration of Receptor Degradation in Human Fibroblasts
... ABSTRACT The metabolism of the receptor for epidermal growth factor (EGF) has been measured by labeling the receptor in vivo with radioactive amino acid precursors and then determining, [r] ...
6
A peptide derived from TIMP-3 inhibits multiple angiogenic growth factor receptors and tumour growth and inflammatory arthritis in mice
... kinase receptors via their extracellular ligand binding domain, rather than their tyrosine kinase ...of receptors that potentially combines the benefits of current anti-angiogenic therapies; having a ...
13
Advances in therapy of breast cancer: overexpression and therapeutic implications of targeting human epidermal growth factor receptors
... Although trastuzumab remains one of the most effective therapies for metastatic HER2- amplified patients, a subset will present with primary refractory disease and most initial responders will develop progression. ...
6