growth factor signaling
Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry
... peptide growth factor sign- aling pathways as well as hypoxia and physical forces [1– ...candidate growth factor peptide lig- and signals can be regulated at many ...peptide growth ...
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Signaling in Context: Parsing the Adhesion Dependence of Growth Factor Signaling
... low growth factor ...of growth factor ...enhance signaling for select growth factors, adhesion may have a net positive effect on the signal- to-noise ratio of detecting and ...
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Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin 1 in non small cell lung cancer
... In Phase III trials, blocking VEGF using the recombin- ant humanized VEGF monoclonal antibody Bevacizumab (Avastin®) has proven successful in increasing the objective tumor response rate and in prolonging ...
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<p>Nerve Growth Factor Signaling and Its Contribution to Pain</p>
... Nerve growth factor (NGF) is a neurotrophic protein essential for the growth, differentiation, and survival of sympathetic and sensory afferent neurons during ...stream signaling alter ...
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Anticancer drug targets: growth factors and growth factor signaling
... Two groups have recently described novel MEK in- hibitors (Table 1). Parke-Davis Pharmaceutical Re- search, which described the first MEK inhibitor, PD- 098059, identified a more potent and selective compound (PD-184352) ...
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Mitochondrial movement and positioning in axons: the role of growth factor signaling
... Many NGF-stimulated effects on neurons are reported to require the internalization and retrograde transport of the receptor–ligand complex (Heerssen and Segal, 2002). However, at least some changes in function at the ...
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Vascular endothelial growth factor signaling in development and disease
... VEGFC/VEGFR3 signaling axes in angiogenesis and lymphangiogenesis, ...the signaling downstream of these crucial ...their signaling functions seem to involve heterodimerization at the ligand and ...
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Growth control of lung cancer by interruption of 5 lipoxygenase mediated growth factor signaling
... Our work demonstrates that the lipoxygenase pathway of AA metabolism is activated in SCLC cells after stimulation by two growth factors. We show that 5-HETE is a major early 5-LO Figure 4. Effect of AA pathway in- ...
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Analysis of growth factor signaling in genetically diverse breast cancer lines
... analyzed growth factor responsiveness in a canonical collection of 39 breast cancer cell lines of the NCI-ICBP43 set, whose genotypes span many of the mutations observed in primary disease ...different ...
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Vascular endothelial growth factor signaling requires glycine to promote angiogenesis
... endothelial growth factor (VEGF) induces angiogenesis and can potentially be used to treat ischemic diseases, yet in clinical trials VEGF has not fulfilled its full potential with side ...
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Mechanisms linking obesity and gastrointestinal cancers
... insulin-like growth factor signaling pathways, chronic inflammation associated to obesity, altered adipokine and inflammatory factors levels, are being ...
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GLP 1 receptor agonists show neuroprotective effects in animal models of diabetes
... insulin signaling in rats with ...insulin signaling was re-sensitized following activation of GLP-1 receptors, as illustrated by reduction of phospho-IRS1 Ser1101 levels and by pAkt Ser473 upregulation and ...
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Epidermal Growth Factor Receptor and Transforming Growth Factor-β Signaling Contributes to Variation for Wing Shape in Drosophila melanogaster
... significant factor, as ‘‘residual’’ line effects among wild types procured from crosses to each mutant did not contribute a significant amount of variation relative to the replicate effects (not ...in ...
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A Tale of Breast Cancer, Behavior and Brains as Affected by Diet and Claudins
... out growth and elongation the fat pad and stroma are ...Transforming growth factor (TGF) promotes the synthesis of ECM and build up the matrix during spatial ...of growth and development ...
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Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer
... Multiple genetic aberrations in FGFR2 triggering the activation of up and/or downstream FGFR2 signaling pathways have been identified in breast cancer. For instance, 6 out of 165 (3.6%) of triple-negative breast ...
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SNPs, linkage disequilibrium, and chronic mountain sickness in Tibetan Chinese
... Most of the SNPs used in this pairwise LD study have been found to be associated with CMS. These alterations were discussed with regard to changes in gene regulation as a possible cause for CMS. The ACE (I/D) rs4340 SNP ...
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Suppressor of cytokine signaling-2 (SOCS2) and epidermal growth factor (EGF) modulate insulin-like growth factor-I receptor (IGF-IR) signaling in intestinal cancer
... IEC-6 cells infected with SOCS2-expressing adenovirus or empty virus were used as a simple in vitro system to confirm in vivo findings that SOCS2 impacts on AP-1 binding activity. IEC-6 cells are a non-transformed ...
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Alveologenesis: key cellular players and fibroblast growth factor 10 signaling
... endothelial growth factor receptor 2 (Vegfr2 or Flk-1) as an early marker ...endothelial growth factor (VEGF) signaling with three dif- ferent VEGF receptor inhibitors (SU5416, Ki8751, ...
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Epidermal Growth Factor Receptor Is Not Required for Human Cytomegalovirus Entry or Signaling
... AG1478, an EGFR kinase inhibitor, does not inhibit HCMV entry into fibroblasts. EGFR stimulation results in the activa- tion of its intrinsic tyrosine kinase, which subsequently auto- phosphorylates the receptor and ...
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Growth factor levels in leukocyte-poor platelet-rich plasma and correlations with donor age, gender, and platelets in the Japanese population
... Platelet-derived growth factor (PDGF)-BB, transforming growth factor (TGF)-β1, vascular endothelial growth factor (VEGF), epi- dermal growth factor (EGF), ...
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