Guanine nucleotide
New functions for a vertebrate Rho guanine nucleotide exchange factor in ciliated epithelia
... Rho guanine nucleotide exchange factor (RhoGEF), has been studied primarily in tissue culture, where it exhibits transforming ability, associates with and modulates the actin cytoskeleton, regulates neurite ...
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9-24-2014 12:00 AM The Role Of The RNA-Binding Protein Rho Guanine Nucleotide Exchange Factor In The Cellular Stress Response
... observed include: mutant copper/zinc superoxide dismutase (mtSOD1) (Rosen et al., 1993), TAR DNA-binding protein of 43 kDa (TDP-43) (Neumann et al., 2006), fused in sarcoma/translocated in liposarcoma (FUS) (Kwiatkowski, ...
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Lpg0393 of Legionella pneumophila Is a Guanine-Nucleotide Exchange Factor for Rab5, Rab21 and Rab22
... potent guanine-nucleotide exchange factor (GEF) of Rab1 [6,7] and whose N-terminal domain exhibits adenosine monophosphorylation (AMPylation) activity toward Rab1 ...
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The role of the guanine nucleotide binding proteins p21ras in T cell activation and growth
... In a sim ilar experim ent, Jurkat cells transfected w ith 20pgs of EF em pty or EF v-H a-ras w ere subjected to metabolic labelling to assess the guanine nucleotide bound to Ras in these cells. Twenty four ...
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Genetic Interactions in Yeast Between Ypt GTPases and Arf Guanine Nucleotide Exchangers
... stimulate nucleotide exchange by Arf GTPases. Nucleotide exchange by Arf GTPases, the switch from the GDP- to the GTP-bound form, is thought to be crucial for their ...as guanine nucleotide ...
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Decreased bioactivity of the guanine nucleotide binding protein that stimulates adenylate cyclase in hearts from cardiomyopathic Syrian hamsters
... coupling of the guanine nucleotide-binding protein that stimulates adenylate cyclase (Gs) to adenylate cyclase. Cyc complementation assays revealed congruent to 50% less Gs activity in cardiac and skeletal ...
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Original Article Overexpression of GEFT, a Rho family guanine nucleotide exchange factor, predicts poor prognosis in patients with rhabdomyosarcoma
... investigated guanine nucleotide exchange factor, GEFT, at expression level in 45 RMS patients and 36 normal striated muscle controls using immunohistochemistry using tissue ...
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Guanine nucleotide exchange factor H1 can be a new biomarker of melanoma
... GEF-H1, guanine nucleotide exchange factor H1; mRNA, messenger RNA; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; RT-PCR, reverse transcription polymerase chain reaction; SEM, standard ...
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Coordinating the activation of RhoA by diverse RhoGEFs : SmgGDS and G-alpha-q-responsive Dbl family guanine nucleotide exchange factors
... The catalytic guanine nucleotide exchange activity of Dbl family GEFs resides entirely within the DH domain. The structural elucidation of several GEF-GTPase complexes has revealed a conserved mechanism of ...
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Defining diverse mechanisms that regulate the activity of Dbl-family guanine nucleotide exchange factors
... for guanine nucleotide exchange of its cognate GTPases and the attendant morphological consequences, they do not address the underlying mechanistic causes for these ...
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A potential role for guanine nucleotide binding protein in the regulation of endosomal proton transport
... These findings, taken together, indicate that GTP binding proteins are present in endosomal membranes derived from renal cortex and that activation of G protein by GTP and GTP-'y-S stimu[r] ...
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Mechanism of Nucleotide Exchange by Guanine Nucleotide Exchange Factors on the Ras Superfamily of Small G-Proteins
... promoting nucleotide exchange and hence activating Ras (figure ...stimulate nucleotide exchange on Rac in vivo (Nimnual et a l, 1998), suggesting a possible coupling o f the Ras and Rac signalling ...f ...
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Identification of a Nuclear Localization Signal (NLS) within the Pleckstrin Homology (PH) domain of Rho Guanine Nucleotide Exchange Factor (RGNEF)
... The guanine exchange factor (GEF) responsible for RanGTP, known as regulator of chromosome condensation (RCC1), contains an NLS and is localized predominantly in the nucleus ...
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Guanine nucleotide binding regulatory proteins and dual control of adenylate cyclase
... When the resolved subunits of G0 were tested for their ability to inhibit adenylate cyclase activity in platelet membranes, the inhibitory activity of the "activated" dimer was found to [r] ...
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Viperin Targets Flavivirus Virulence by Inducing Assembly of Noninfectious Capsid Particles
... In this study, we show that viperin induces capsid particle release by interacting and inhibiting the function of the cellular protein Golgi brefeldin A-resistant guanine nucleotide exch[r] ...
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Molecular Characterization of In Vivo Adjuvant Activity in Ferrets Vaccinated against Influenza Virus
... Additionally, the level of expression of the guanine nucleotide-activating protein GAP RGS1, involved in B-cell activation 26, which was elevated in the group vaccinated with V2008 plus [r] ...
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A putative novel protein, DEPDC1B, is overexpressed in oral cancer patients, and enhanced anchorage-independent growth in oral cancer cells that is mediated by Rac1 and ERK
... DEPDC1B encodes a protein that may function as a Rho GTPase-activating protein (GAP), according to its intrinsic primary protein sequences; therefore, it may play a role in regulating Rho GTPase activity. Many studies ...
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The Enterohemorrhagic Escherichia coli effector EspW triggers actin remodeling in a Rac1 dependent manner
... The actin cytoskeleton, which is targeted by many bacterial pathogens, is essential for cell integrity, motility, membrane trafficking, and shape changes (14). Rho GTPases, which belong to the family of Ras-related small ...
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Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8
... Recent studies have identified several key regulators of these processes, including Rab GTPases such as Rab8 and Rab11, the Rab8 guanine nucleotide exchange factor Rabin8, and the transp[r] ...
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