guanine nucleotide exchange
Molecular Determinants of the Interaction between Coxsackievirus Protein 3A and Guanine Nucleotide Exchange Factor GBF1
... Identification of regions in the N terminus of GBF1 that are important for interaction with 3A. We also sought to identify the binding domain of 3A in GBF1. All ArfGEFs identified to date have a Sec7 domain, a conserved ...
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Original Article Overexpression of GEFT, a Rho family guanine nucleotide exchange factor, predicts poor prognosis in patients with rhabdomyosarcoma
... guanine nucleotide exchange factor (GEF) family, which is highly expressed in excitable tissues such as the brain, heart, and muscle ...the exchange of bound guanosine diphosphates (GDP) for ...
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Lpg0393 of Legionella pneumophila Is a Guanine-Nucleotide Exchange Factor for Rab5, Rab21 and Rab22
... potent guanine-nucleotide exchange factor (GEF) of Rab1 [6,7] and whose N-terminal domain exhibits adenosine monophosphorylation (AMPylation) activity toward Rab1 ...
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New functions for a vertebrate Rho guanine nucleotide exchange factor in ciliated epithelia
... Rho guanine nucleotide exchange factors (RhoGEFs) are specialized proteins that directly bind to and activate Rho family GTPases in response to upstream regulatory signals, thus linking extracellular ...
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Guanine nucleotide exchange factor H1 can be a new biomarker of melanoma
... GEF-H1, guanine nucleotide exchange factor H1; mRNA, messenger RNA; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; RT-PCR, reverse transcription polymerase chain reaction; SEM, ...
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Regulation of RhoA GTPase signaling by guanine nucleotide exchange factors in response to extracellular matrix adhesion and DNA damage
... which guanine nucleotide exchange factor(s) are responsible for activation of RhoA downstream of fibronectin ...activated exchange factors, we show that the RhoA-specific exchange ...
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9-24-2014 12:00 AM The Role Of The RNA-Binding Protein Rho Guanine Nucleotide Exchange Factor In The Cellular Stress Response
... observed include: mutant copper/zinc superoxide dismutase (mtSOD1) (Rosen et al., 1993), TAR DNA-binding protein of 43 kDa (TDP-43) (Neumann et al., 2006), fused in sarcoma/translocated in liposarcoma (FUS) (Kwiatkowski, ...
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Coordinating the activation of RhoA by diverse RhoGEFs : SmgGDS and G-alpha-q-responsive Dbl family guanine nucleotide exchange factors
... of guanine nucleotide exchange of Rho has required the use of highly robust assays for small GTPase ...of guanine nucleotides ...from nucleotide-bound forms of GTPases using ...
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Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte intrinsic signaling to maintain skin homeostasis
... RAB guanine nucleotide exchange factor 1 (RABGEF1, also known as RABEX-5) severely impairs epidermal barrier function in mice and induces an allergic cutaneous and systemic ...
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The Putative Guanine Nucleotide Exchange Factor RicA Mediates Upstream Signaling for Growth and Development in Aspergillus
... the guanine nucleotide exchange caused by ligand-bound (sensitized) GPCRs, causing the dissociation of the GTP-bound G ␣ subunit and the G ␥ heterodimer, which then transduce signals by interacting ...
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Defining diverse mechanisms that regulate the activity of Dbl-family guanine nucleotide exchange factors
... for guanine nucleotide exchange of its cognate GTPases and the attendant morphological consequences, they do not address the underlying mechanistic causes for these ...
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Identification of a Nuclear Localization Signal (NLS) within the Pleckstrin Homology (PH) domain of Rho Guanine Nucleotide Exchange Factor (RGNEF)
... The guanine exchange factor (GEF) responsible for RanGTP, known as regulator of chromosome condensation (RCC1), contains an NLS and is localized predominantly in the nucleus ...
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GBF1, a Guanine Nucleotide Exchange Factor for Arf, Is Crucial for Coxsackievirus B3 RNA Replication
... The replication of enteroviruses is sensitive to brefeldin A (BFA), an inhibitor of endoplasmic reticulum- to-Golgi network transport that blocks activation of guanine exchange factors (GEFs) of the Arf ...
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Guanine Nucleotide Exchange Factor 7B (RopGEF7B) is involved in floral organ development in Oryza sativa
... of both osropgef7b-1 mutant (Additional file 1 : Figure S4D-F, M) and RNAi L31 plant (Additional file 1 : Figure S4J-M) were not different from those of the wild type (Add- itional file [r] ...
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Role of the Guanine Nucleotide Exchange Factor Rom2 in Cell Wall Integrity Maintenance of Aspergillus fumigatus
... A spergillus fumigatus is an airborne opportunistic human pathogen that causes severe invasive diseases in immunocom- promised patients. The outcome is often fatal due to limited ther- apeutic options. All major drugs ...
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Mechanism of Nucleotide Exchange by Guanine Nucleotide Exchange Factors on the Ras Superfamily of Small G-Proteins
... As stated in section 2.1.1 the first step of N-Ras.GDP purification was over a Q- sepharose ion exchange column. The N-Ras.GDP protein peak was identified by SDS-PAGE and filter binding assays for [^H]GDP and ...
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Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells
... The association of E-cadherin with the actin cytoskeleton is necessary for strong mechanical cell-cell interaction. This interaction is mediated via E-cadherin-bound β-cat- enin and α-catenin, which in turn is associated ...
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Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1b in platelets
... Rap1b plays a key role [2]. Indeed, Rap1b is activated in response to agonists [3] and platelets from Rap1b knock- out mice exhibit defects in αIIbβ3 integrin-dependent arterial thrombus formation [4]. Rap1b cycles ...
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Unfractionated heparin ameliorates pulmonary microvascular endothelial barrier dysfunction via microtubule stabilization in acute lung injury
... in guanine nucleotide exchange factor (GEF-H1) expression and myosin phosphatase target subunit 1 (MYPT1) phosphorylation, and microtubule (MT) disassembly in LPS-induced ALI mouse model and human ...
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