guanine nucleotide exchange factor
9-24-2014 12:00 AM The Role Of The RNA-Binding Protein Rho Guanine Nucleotide Exchange Factor In The Cellular Stress Response
... observed include: mutant copper/zinc superoxide dismutase (mtSOD1) (Rosen et al., 1993), TAR DNA-binding protein of 43 kDa (TDP-43) (Neumann et al., 2006), fused in sarcoma/translocated in liposarcoma (FUS) (Kwiatkowski, ...
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Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte intrinsic signaling to maintain skin homeostasis
... RAB guanine nucleotide exchange factor 1 (RABGEF1, also known as RABEX-5) severely impairs epidermal barrier function in mice and induces an allergic cutaneous and systemic ...
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Original Article Overexpression of GEFT, a Rho family guanine nucleotide exchange factor, predicts poor prognosis in patients with rhabdomyosarcoma
... guanine nucleotide exchange factor (GEF) family, which is highly expressed in excitable tissues such as the brain, heart, and muscle ...the exchange of bound guanosine diphosphates ...
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New functions for a vertebrate Rho guanine nucleotide exchange factor in ciliated epithelia
... Rho guanine nucleotide exchange factor (RhoGEF), has been studied primarily in tissue culture, where it exhibits transforming ability, associates with and modulates the actin cytoskeleton, ...
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A Role for the Noncatalytic N Terminus in the Function of Cdc25, a Saccharomyces cerevisiae Ras-Guanine Nucleotide Exchange Factor
... The Saccharomyces cerevisiae CDC25 gene encodes a guanine nucleotide exchange factor (GEF) for Ras proteins. Its catalytic domain is highly homologous to Ras-GEFs from all eukaryotes. Even ...
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Molecular Determinants of the Interaction between Coxsackievirus Protein 3A and Guanine Nucleotide Exchange Factor GBF1
... The 3A protein of coxsackievirus B3 (CVB3), a small membrane protein that forms homodimers, inhibits endoplasmic reticulum-to-Golgi complex transport. Recently, we described the underlying mechanism by showing that the ...
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Guanine Nucleotide Exchange Factor OSG-1 Confers Functional Aging via Dysregulated Rho Signaling in Caenorhabditis elegans Neurons
... ABSTRACT Rho signaling regulates a variety of biological processes, but whether it is implicated in aging remains an open question. Here we show that a guanine nucleotide exchange factor of ...
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Role of the Guanine Nucleotide Exchange Factor Rom2 in Cell Wall Integrity Maintenance of Aspergillus fumigatus
... Aspergillus fumigatus is a mold and the causal agent of invasive aspergillosis, a systemic disease with high lethality. Recently, we identified and functionally characterized three stress sensors implicated in the cell ...
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Lpg0393 of Legionella pneumophila Is a Guanine-Nucleotide Exchange Factor for Rab5, Rab21 and Rab22
... potent guanine-nucleotide exchange factor (GEF) of Rab1 [6,7] and whose N-terminal domain exhibits adenosine monophosphorylation (AMPylation) activity toward Rab1 ...
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Guanine nucleotide exchange factor H1 can be a new biomarker of melanoma
... GEF-H1, guanine nucleotide exchange factor H1; mRNA, messenger RNA; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; RT-PCR, reverse transcription polymerase chain reaction; ...
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The Putative Guanine Nucleotide Exchange Factor RicA Mediates Upstream Signaling for Growth and Development in Aspergillus
... the guanine nucleotide exchange caused by ligand-bound (sensitized) GPCRs, causing the dissociation of the GTP-bound G ␣ subunit and the G ␥ heterodimer, which then transduce signals by interacting ...
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Pioneer Axon Navigation Is Controlled by AEX-3, a Guanine Nucleotide Exchange Factor for RAB-3 in Caenorhabditis elegans
... The AVG axon pioneers the right axon tract of the VNC in C. elegans and is critical for the navigation of follower axons (Durbin 1987; Hutter 2003). We isolated an allele of aex-3 in an enhancer screen for AVG axon ...
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The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase 3 production in rheumatoid arthritis synovial tissue
... of guanine nucle- otide exchange factors (GEFs), which catalyze the exchange of GDP on inactive GTPase for ...Ras guanine nucleotide-releasing factor 1 (RasGRF) coupling to G ...
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Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cells
... activates nucleotide-free Cdc42 via its CZH2 [CDM (ced5/DOCK180/myoblast city)-Zizimin homology 2] domain [4] and mediates positive feedback on the active form, GTP-bound Cdc42 ...
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GBF1, a Guanine Nucleotide Exchange Factor for Arf, Is Crucial for Coxsackievirus B3 RNA Replication
... The replication of enteroviruses is sensitive to brefeldin A (BFA), an inhibitor of endoplasmic reticulum- to-Golgi network transport that blocks activation of guanine exchange factors (GEFs) of the Arf ...
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Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility
... In contrast to the Morris water maze task, which is based on the avoidance behavior of mice escaping from water, the automated IntelliCage apparatus enabled us to measure spatial memory [r] ...
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The Interplay between the Escherichia coli Rho Guanine Nucleotide Exchange Factor Effectors and the Mammalian RhoGEF Inhibitor EspH
... nine nucleotide exchange factors (GEFs), which promote dissoci- ation of GDP and subsequent binding of GTP and GTPase- activating proteins (GAPs), which enhance the rate of GTP hydrolysis to GDP, while ...
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Guanine Nucleotide Exchange Factor 7B (RopGEF7B) is involved in floral organ development in Oryza sativa
... of both osropgef7b-1 mutant (Additional file 1 : Figure S4D-F, M) and RNAi L31 plant (Additional file 1 : Figure S4J-M) were not different from those of the wild type (Add- itional file [r] ...
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Characterization of Synthetic-Lethal Mutants Reveals a Role for the Saccharomyces cerevisiae Guanine-Nucleotide Exchange Factor Cdc24p in Vacuole Function and Na+ Tolerance
... The isolation of two different mutants, one affecting vacuole morphology and the other in a vacuolar ATPase gene, that both exhibit synthetic-le- thality with cdc24-4h [r] ...
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Essential Role of the NH2-Terminal Region of Cdc24 Guanine Nucleotide Exchange Factor in Its Initial Polarized Localization in Saccharomyces cerevisiae
... At 120 min after release, wild-type GFP-Cdc24 localized to the site of FIG 3 Cdc24-ts proteins are defective in their initial polarized localization in the absence of Bem1.. Cells grown [r] ...
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