guanylyl cyclases
Preliminary characterization of two atypical soluble guanylyl cyclases in the central and peripheral nervous system of Drosophila melanogaster
... these guanylyl cyclases play a role in sensory transduction during larval ...life. Guanylyl cyclases and cGMP signaling have been demonstrated to play an important role in several types of ...
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Searching for Neuronal Left/Right Asymmetry: Genomewide Analysis of Nematode Receptor-Type Guanylyl Cyclases
... the guanylyl cyclase (gcy) gene ...receptor-type guanylyl cyclases and of 7 gcy genes encoding soluble guanylyl cyclases in the complete genome sequence of ...receptor-type ...
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Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes
... Particulate guanylyl cyclase re- ceptors are structurally similar to tyrosine kinase receptors; the GC-B is not uncommon in this regard, itself harbouring a tyrosine-kinase-like ...ticulate guanylyl ...
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Two-component cyclase opsins of green algae are ATP-dependent and light-inhibited guanylyl cyclases
... light-inhibited guanylyl cyclases regulated through a two-component-like phosphoryl transfer, called “ two-component cyclase opsins ” (2c- ...demonstrating guanylyl cyclase activity of Vc2c-Cyclop1 ...
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Identification of Guanylyl Cyclases That Function in Thermosensory Neurons of Caenorhabditis elegans
... a guanylyl cyclase producing cGMP and a phosphodiesterase de- grading cGMP are also likely to be involved in thermo- sensory signal transduction (K omatsu et ...encoding guanylyl cyclases and show ...
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Synaptic transmission in neurons that express the Drosophila atypical soluble guanylyl cyclases, Gyc 89Da and Gyc 89Db, is necessary for the successful completion of larval and adult ecdysis
... Our previous studies using whole-mount in situ hybridization labeling in embryos showed that all three atypical sGC subunit genes, Gyc-89Da, Gyc-89Db and Gyc-88E, were expressed in a sub[r] ...
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Receptor guanylyl cyclases
... different guanylyl cyclase cell receptors are known, but others will likely be discovered within the next few ...by guanylyl cyclase receptors include synovial fluid, uterine/oviductal luminal fluid, ...
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The Importance of cGMP Signaling in Sensory Cilia for Body Size Regulation in Caenorhabditis elegans
... GCY-12, together with most of the other receptor-type guanylyl cyclases in C. elegans, contains a conserved extracellular domain, the receptor family ligand-binding region [RFLBR (PF01094)]. The presence of ...
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Differential expression of mRNA for guanylyl cyclase linked endothelium derived relaxing factor receptor subunits in rat kidney
... Endothelium-derived relaxing factor (EDRF) has profound effects on the renal vasculature, the glomerular mesangium, and also affects renal salt excretion. EDRF stimulates guanylyl cyclases, which are ...
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MsGC β3 forms active homodimers and inactive heterodimers with NO sensitive soluble guanylyl cyclase subunits
... soluble guanylyl cyclases that have been investigated, whether mammalian or insect, are obligate heterodimers, requiring coexpression of an alpha and a beta subunit for activity (Lucas et ...of ...
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Pharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis
... membrane-bound guanylyl cyclases, is a homodimeric transmembrane enzyme exhibiting conserved functional domains (Figure 3A), including: (1) the extracellular domain for specific ligand binding; (2) a single ...
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Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH induced decrease in cGMP that causes resumption of meiosis in rat oocytes
... as guanylyl cyclase-B (Zhang et ...relevant guanylyl cyclase in mouse follicles because follicle-enclosed oocytes in the ovaries of mice with non-functional NPR2 resume meiosis spontaneously (Zhang et ...
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The beta2 subunit inhibits stimulation of the alpha1/beta1 form of soluble guanylyl cyclase by nitric oxide Potential relevance to regulation of blood pressure
... Cytosolic guanylyl cyclases (GTP pyrophosphate-lyase [cy- clizing; EC ...of guanylyl cyclase has the greatest activity and is considered the uni- versal ...of guanylyl cyclase and NO- ...
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Pressure independent cardiac hypertrophy in mice with cardiomyocyte restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase A
... receptor guanylyl cyclase-A (GC-A) might contribute to the increased propensity to cardiac hypertrophy, although a causative role in vivo has not been definitively demon- ...
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Functional Specialization in Vibrio cholerae Diguanylate Cyclases: Distinct Modes of Motility Suppression and c di GMP Production
... ABSTRACT Vibrio cholerae biofilm formation and associated motility suppression are correlated with increased concentrations of cyclic diguanylate monophosphate (c-di-GMP), which are in turn driven by increased levels ...
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Insect Stage-Specific Adenylate Cyclases Regulate Social Motility in African Trypanosomes
... Sophisticated systems for cell-cell communication enable unicellular microbes to act as multicellular entities capable of group- level behaviors that are not evident in individuals. These group behaviors influence ...
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Expression of C-type Natriuretic Peptide and its Specific Guanylyl Cyclase-Coupled Receptor in Pig Ovarian Granulosa Cells
... The present study was undertaken to investigate the expression of C-type natriuretic peptide (CNP) and its speci fi c guanylyl cyclase (GC)-coupled receptor in the granulosa cells of [r] ...
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Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes
... specific guanylyl cyclase-B (GC-B) receptor, encoded by the Npr2 gene and lead to a localized increase in cyclic guanosine 3’,5’ monophosphate (cGMP) signaling (Potter et ...
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Different Responses of Two Genes Associated with Disease Resistance Loci in Maize (Zea mays L.) to 3-allyloxy-1,2-benzothiazole 1,1-dioxide
... In plants, cGMP is involved in modulating gene expression of many defense and stress related pathways either functioning alone or combining with calcium (Bowler et al., 1994). Whether the guanylyl cyclase plays ...
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A uroguanylin GUCY2C endocrine axis regulates feeding in mice
... Although guanylyl cyclase and downstream cGMP signaling are essential regulators of feeding behavior and satiation in invertebrates (2, 3), the role for this primordial sig- naling mechanism in mammalian appetite ...
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