H(P)ETE
12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-κB pathway in ovarian cancer
... Figure S3 12-heTe inhibits cell apoptosis and promotes the activation of nF-κB through the ilK pathway in ovarian cancer cells. (A) The protein level of ilK was obviously knocked down by another independent siRna ...
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20 Hydroxyeicosa tetraenoic acid (20 HETE) activates protein kinase C Role in regulation of rat renal Na+,K+ ATPase
... and can be metabolized via at least three different pathways: the cyclooxygenase, the lipoxygenase and the cytochrome P-450 monooxygenase pathways (P-450) (for review, see references 1, 2). The P-450 metabolites of ...
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Eicosanoid excretion in hepatic cirrhosis Predominance of 20 HETE
... The cytochrome P450 system transforms AA to hydroxy- eicosatetraenoic acid (HETE) metabolites that are vasoac- tive and affect transport in several nephron segments. A principal product of this system, ...
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Effects of delayed estrogen treatment and 20 HETE synthesis inhibition on postischemic pial artery response to acetylcholine in rats
... After cranial window construction, the animals were recovered for 30 min before obtaining baseline pial arte- riole diameter measurements. Ach (10 μmol/L) was in- fused (0.2 mL/min) into the window and allowed to dwell ...
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Combination of vatalanib and a 20-HETE synthesis inhibitor results in decreased tumor growth in an animal model of human glioma
... Notes: (A) Treatment with vatalanib causes decrease in expression of VegFr2 but increases the expression of hiF-1a and VegF, which will cause increased neovascularization and tumor growth. (B) When heT0016 alone is used, ...
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TGF-β1/FGF-2 signaling mediates the 15-HETE-induced differentiation of adventitial fibroblasts into myofibroblasts
... The differentiation of fibroblasts into myofibroblasts is regulated by a complex microenvironment consisting of growth factors, cytokines, adhesion molecules, and ECM molecules. To examine whether FGF-2 is involved in ...
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Studies on the mechanism of omega hydroxylation of platelet 12 hydroxyeicosatetraenoic acid (12 HETE) by unstimulated neutrophils
... Stimulated platelets, in the presence or absence of aspirin, synthesize significant quantities of 12-hydroxyeicosatetraenoic acid (12-HETE), which is chemotactic and chemokinetic, and enhances mononuclear cell ...
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Targeting 20-HETE producing enzymes in cancer – rationale, pharmacology, and clinical potential
... The biggest challenge with attempts to define 20-HETE signaling is that to date, the specific cellular receptor of 20-HETE has not been identified. In striking contrast to PGs (whose G-protein coupled ...
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20-HETE Mediates Ozone-Induced, Neutrophil-Independent Airway Hyper-Responsiveness in Mice
... the exhaled breath condensate than subjects with less sensitive airways following an acute exposure to ozone [16]. In the present study, BAL fluid from mice exposed to ozone (6 ppm, 2 h, T = 0 h) was analyzed for ...
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Differential gene expression mediated by 15 hydroxyeicosatetraenoic acid in LPS stimulated RAW 264 7 cells
... Ingenuity Pathway Analysis (IPA) software was used to examine biological relationships associated with 15- HETE-mediated expression changes. Identifiers and rela- tive levels of altered genes comprising the data ...
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May 28, Joe Hete CEO, ABX Air 145 Hunter Drive Wilmington, OH Dear Mr. Hete:
... Prior to carrying out research with animals, scientists must demonstrate that the proposed study is scientifically sound, determine whether the animal model proposed is the most approp[r] ...
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Reversal of Delayed Vasospasm by TS 011 in the Dual Hemorrhage Dog Model of Subarachnoid Hemorrhage
... P revious studies indicated that arachidonic acid is metabo- lized by cytochrome P450 (CYP) enzymes in cerebral ar- teries to 20-hydroxyeicosatetraenoic acid (20-HETE) and that this compound plays an important ...
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Heteroscedastic and Homoscedastic GLMM and GLM: Application to Effort Estimation in the Gulf of Mexico Shrimp Fishery, 1984 through 2001
... Efforts generated via a GLMM and a GLM for both homoscedastic and heteroscedastic models showed that although each data set was heteroscedastic, the severity of the hete[r] ...
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Body mass index and dental caries in young people: a systematic review
... This review has identified several factors that appear to be important when examining the relationship be- tween weight status and caries, and these factors may also account for the hete[r] ...
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A Review on Fog Computing and its Applications
... Generally fog concept orally represented as “Fog computing is a geographically distributed computing architecture with a resource pool consists of one or more ubiquitously connected hete[r] ...
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Detecting Market Anomalies: Do Evidences hold in Nigeria?
... The tests jointly revealed strong presence of inefficiency as anomalies can be traced to persisted volatility, lack of randomity, significant effects of information and hete[r] ...
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Sex determination in polyploids of Caenorhabditis elegans.
... was not directly determined. Experiments involving X chromosome duplications in triploids: For testing the effect of an X chromosome dupli- cation, diploid males hete[r] ...
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Next-generation whole-exome sequencing contribution to identification of rare autosomal recessive diseases
... Exome sequencing identifies compound heterozy- gous PKHD1 mutations as a cause of autosomal recessive polycystic kidney disease.. Unexpected allelic hete- rogeneity and s[r] ...
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Functional effect of Saffron supplementation and risk genotypes in early age related macular degeneration: a preliminary report
... The improvement of macular function after Saffron supplementation, as evidenced by an increase in retinal flicker sensitivity, did not differ significantly between patients who were hete[r] ...
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GENETIC CONTROL OF AN ACID PHOSPHATASE IN TETRAHYMENA: FORMATION OF A HYBRID ENZYME
... The properties of Bands 2, 3, and 4 in cells of different genotype may help to elucidate the relationship of the isozymes of homozygotes to the hybrid enzymes observed in hete[r] ...
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