H3K79 methylation
Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide
... Our findings are not the first to detect associations between this H3K79 methylation pathway and blood pressure regulation. Dot1 conditional knockout mice were shown to exhibit salt sensitive hypertension ...
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Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival
... the H3K79 methylation levels in the OCI-AML3 cell line, particularly H3K79me2/3, were similar to those in THP-1 cells but were much higher than those in the other cells ...of H3K79 hypermethylation ...
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A Novel Histone Crosstalk Pathway Important for Regulation of UV-Induced DNA Damage Repair in Saccharomyces cerevisiae
... specific H3K79 methylation states play distinct roles in UV repair in ...yeast. H3K79 can possess up to three methyl groups per res- idue (denoted H3K79me1, me2, and me3), catalyzed by his- tone ...
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Dot1l expression predicts adverse postoperative prognosis of patients with clear-cell renal cell carcinoma
... the H3K79 position ...tri- methylation of H3K79 specifically with a unique catalytic ...Dot1l-mediated H3K79 methylation is associated with many biological processes including ...
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Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives
... methylate H3K79 as part of a transcription complex, which can initiate or maintain an active tran- scription ...lated H3K79 are located at transcriptionally inactive loci, while the remaining 90 % genes ...
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Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer
... Importantly, DOT1L also plays a pivotal role in tu- mors, especially leukemia [13, 14] and thymic lymphoma [15, 16]. In leukemia, DOT1L forms a protein complex with the mix lineage leukemia (MLL) fusion proteins and ...
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Histone H3K79 methyltransferase Dot1L is directly activated by thyroid hormone receptor during Xenopus metamorphosis
... H3K79 methylation is one of a large number of post- translational modifications that occurs at the histone tails in eukaryotic cells ...lysine methylation residues include K4, K9, K27, and K79 of ...
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Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing
... Recent studies have demonstrated that knockdown of DOT1L effectively reduced the H3K79 methylation level in AML cell lines [29, 59] and impeded leukemia cell proliferation [60]. Since DOT1L is the sole ...
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The Double-Strand Break Landscape of Meiotic Chromosomes Is Shaped by the Paf1 Transcription Elongation Complex in Saccharomyces cerevisiae
... H3 methylation promoted by Paf1C, H3K4me (me1, me2, and me3) and H3K79me (me3), in cell lysates by Western blotting (Figure ...H3K4 methylation in the rtf1 mu- tant might be due to reduced Set1/COMPASS ...
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Tri-methylation of H3K79 is decreased in TGF-β1-induced epithelial-to-mesenchymal transition in lung cancer
... Histone methylation is a well-balanced mechanism guided by histone methyltransferases and ...for H3K79, and its recruitment is ubiquitously coupled with ...between H3K79 and H3K4 methylation ...
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Gassen, Alwine (2012): Functional analysis of DOT1-dependent histone H3 lysine 76 methylation during cell cycle progression in Trypanosoma brucei. Dissertation, LMU München: Fakultät für Biologie
... H3K79 methylation levels fluctuate within the cell cycle in yeast and human cells suggesting a potential role in cell cycle ...different methylation states of H3K79 suggested by Frederiks and ...
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Combination of serum RASSF1A methylation and AFP is a promising non-invasive biomarker for HCC patient with chronic HBV infection
... RASSF1A methylation was significantly lower than that of the patients without RASSF1A ...RASSF1A methylation may originate in circulating tumor cells, which then leads to tumor ...
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Methylation Abnormalities in Mammary Carcinoma: The Methylation Suicide Hypothesis
... prominent methylation abnormality found in cancer genomes, but the mechanism and possible biological function of demethylation is ...have methylation levels reduced to be close to the point where apoptosis ...
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Association between long interspersed nuclear element-1 methylation levels and relapse in Wilms tumors
... its methylation levels on the prognosis of patients with cancer [27], such as colon [28], gastric [29], and hepatocellular [30] ...LINE-1 methylation levels in tumor compared to matched normal kidney ...
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Deep characterization of a common D4Z4 variant identifies biallelic DUX4 expression as a modifier for disease penetrance in FSHD2
... phenotype, while the clinical consequences of arrays 8 – 10 units are highly unpredictable and can also be found in the control population [16, 23]. Recently, several groups showed that for carriers of 7 – 10 unit D4Z4 ...
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Is the Fungus Magnaporthe Losing DNA Methylation?
... DNA methylation is believed to be a potent defense mecha- nism against TEs in a wide range of eukaryotic ...DNA methylation actually functioned effectively to suppress the MAGGY element at the ...
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Mono-allelic retrotransposon insertion addresses epigenetic transcriptional repression in human genome
... Generally, our results agree with previous reports that retrotransposons may repress gene expression through an epigenetic mechanism. Our study strongly supports the observations that young active retrotransposons insert ...
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Distinct roles of DNMT1 dependent and DNMT1 independent methylation patterns in the genome of mouse embryonic stem cells
... CHH methylation and asymmetric CG methyla- tion in our ...CG methylation symmetry to the level of WT ...of methylation bias at each CG site on both the sense and antisense strands by introducing the ...
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Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer
... of methylation during tumor progression and metastatic spread may indeed provide some potential ex- ...in methylation in distant hepatic and lung metas- tases but an increased incidence of local metastases ...
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EVALUATION OF HYPERMETHYLATION OF RAS ASSOCIATION DOMAIN FAMILY-1 A AND GLUTATHIONE S-TRANSFERASE PROTEIN-1 GENES AS DIAGNOSTIC MARKER FOR HEPATOCELLULAR CARCINOMA
... between methylation of both tumour suppressor gene and AFP levels can help diagnosis by Estimating both AFP with the examination of methylation status of RASSF1A and GSTP genes ,which increases sensitivity ...
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