H5N1 Vaccine
A Single-Dose Influenza A (H5N1) Vaccine Safe and Immunogenic in Adult and Elderly Patients: an Approach to Pandemic Vaccine Development
... pathogenic H5N1 strains, there has been considerable interest in developing pandemic ...adjuvanted H5N1 vaccine in adult and elderly ...the vaccine or one dose of 6 or 12 ...present ...
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Assessment of Route of Administration and Dose Escalation for an Adenovirus-Based Influenza A Virus (H5N1) Vaccine in Chickens
... HPAI vaccine to prevent the disease in commercial and backyard birds must be effective, safe, and ...adenovirus-based H5N1 HPAI vaccine ...Ad5.HA vaccine and its cost-effectiveness, studies to ...
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Induction of Broadly Reactive Anti-Hemagglutinin Stalk Antibodies by an H5N1 Vaccine in Humans
... subunit H5N1 vaccine 21 days apart ...virosomal vaccine containing 30 g of HA, and the three other groups received ...after H5N1 vaccination ...The H5N1 booster vaccination increased ...
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Oligomeric Recombinant H5 HA1 Vaccine Produced in Bacteria Protects Ferrets from Homologous and Heterologous Wild-Type H5N1 Influenza Challenge and Controls Viral Loads Better than Subunit H5N1 Vaccine by Eliciting High-Affinity Antibodies
... from H5N1 (A/Vietnam/1203/04) with the egg-based licensed subunit H5N1 (SU-H5N1) vaccine in a ferret challenge model using two differ- ent clades of highly pathogenic (HP) H5N1 ...
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Persistence of Antibody to Influenza A/H5N1 Vaccine Virus: Impact of AS03 Adjuvant
... Influenza Vaccine Stockpile ...selected vaccine antigen to maximize protective antibody responses while minimizing the antigenic content (dose ...virus vaccine mixed with the AS03 ...
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Growth Determinants for H5N1 Influenza Vaccine Seed Viruses in MDCK Cells
... Currently, H5N1 prepan- demic human vaccines are being stockpiled in many ...inactivated H5N1 vaccines are produced from viruses propagated in embryonated chicken ...to H5N1 viruses, however, it is ...
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Protein Microarray Analysis of the Specificity and Cross-Reactivity of Influenza Virus Hemagglutinin-Specific Antibodies
... (ii) H5N1 vaccine ...2) H5N1 vaccine was administered more than 1 year ...(A/Vietnam/1203/2004) H5N1 vaccine (identifier NCT00680069) (34) (see ...booster vaccine; 10 ...
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Neutralizing Epitopes of Influenza Virus Hemagglutinin: Target for the Development of a Universal Vaccine against H5N1 Lineages
... from vaccine-in- duced immunity in the human population through antigenic drift ...from vaccine-induced antibody responses (34). Although current H5N1 vaccine candidates continue to provide ...
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Immunogenicity and Safety of MF59-Adjuvanted H5N1 Influenza Vaccine From Infancy to Adolescence
... the H5N1 vaccine, and 137 subjects received the seasonal ...the H5N1 vaccine antigen were 97% for children 6 to 36 months and 3 to 9 years of age and 89% for older ...no vaccine-related ...
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An M2e based multiple antigenic peptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses
... of H5N1 viruses, matrix protein 2 (M2) is the most ...attractive vaccine target. Currently, the rapid evolu- tion of H5N1 virus and the co-circulation of multiple antigenic variants in multiple ...
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Intranasal Vaccination with 1918 Influenza Virus-Like Particles Protects Mice and Ferrets from Lethal 1918 and H5N1 Influenza Virus Challenge
... studying vaccine efficacy against a pandemic ...effective vaccine against this recognized ...by H5N1 viruses (15, 25, 34; ...improved vaccine technologies. To date, clinical evaluations of ...
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A New Generation of Modified Live-Attenuated Avian Influenza Viruses Using a Two-Strategy Combination as Potential Vaccine Candidates
... H7N2 vaccine virus at 2 weeks of age and subsequent challenge with the wild-type H7N2 LPAI virus resulted in complete ...HPAI H5N1. In this case, we reconstituted an att H5N1 vaccine virus, ...
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H5N1-SeroDetect EIA and Rapid Test: a Novel Differential Diagnostic Assay for Serodiagnosis of H5N1 Infections and Surveillance
... against H5N1 viruses has been described elsewhere ...low H5N1 specificity, as some samples from seasonal influenza convalescent patients reacted positively in the H5N1 ...Our H5N1-SeroDetect ...
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An Adjuvant for the Induction of Potent, Protective Humoral Responses to an H5N1 Influenza Virus Vaccine with Antigen-Sparing Effect in Mice
... the vaccine in both strains of mice; however, the antibody titers achieved in TLR3 ⫺/⫺ mice were lower than those in TLR3 ⫹/⫹ mice, though the difference did not reach statistical significance (P, ...adjuvanted ...
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Glycosylation at 158N of the Hemagglutinin Protein and Receptor Binding Specificity Synergistically Affect the Antigenicity and Immunogenicity of a Live Attenuated H5N1 A/Vietnam/1203/2004 Vaccine Virus in Ferrets
... (H5N1) vaccine virus (VN04 ca) has receptor binding specificity to ␣ 2,3-linked sialosides ( ␣ 2,3SAL), and a single dose induces a minimal serum antibody response in mice and ...(H5N1) ...
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Long term booster schedules with AS03A adjuvanted heterologous H5N1 vaccines induces rapid and broad immune responses in Asian adults
... the vaccine strain (A/Vietnam/1194/2004; clade 1), but not a drifted strain (A/Indonesia/5/2005; clade ...non-adjuvanted H5N1 vaccine did not fulfill licensure criteria for immunogenicity against ...
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A phase II, open label, multicentre study to evaluate the immunogenicity and safety of an adjuvanted prepandemic (H5N1) influenza vaccine in healthy Japanese adults
... influenza vaccine formulated with an a -tocopherol containing, oil-in-water (O/W) emul- sion-based Adjuvant System, ...This vaccine has demonstrated a good safety profile in randomised clini- cal trials in ...
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Recombinant Parainfluenza Virus 5 Expressing Hemagglutinin of Influenza A Virus H5N1 Protected Mice against Lethal Highly Pathogenic Avian Influenza Virus H5N1 Challenge
... FDA-approved vaccine against H5N1 has serious limitations, particularly as it has to be given twice and requires substantially higher concentrations of the vaccine to achieve a moderate level of ...
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Antigenic Profile of Avian H5N1 Viruses in Asia from 2002 to 2007
... of H5N1 virus is a false alarm or an indication of another pandemic in the ...effective vaccine will be vital to alleviating the next ...a vaccine may not be available until several months after a ...
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Mosaic H5 Hemagglutinin Provides Broad Humoral and Cellular Immune Responses against Influenza Viruses
... and native sequence (VN/1203/04) vaccines (MVA-HA) were compared. First, ICS was conducted to compare MVA-H5M and MVA-HA vaccines. Splenocytes from both MVA-H5M and MVA-HA vaccinated mice were collected at 6 weeks ...
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