hair cells
Mutations in Protocadherin 15 and Cadherin 23 Affect Tip Links and Mechanotransduction in Mammalian Sensory Hair Cells
... av6J/av6J hair cells (see ...and hair-cell nuclei for 23 hair cells for each genotype, for both the apical and basal coils, using a 400 pixel (206 20) region of ...
16
Stem cells for the replacement of inner ear neurons and hair cells
... stem cells grew processes that contacted hair cells in an explant of the organ of Corti that had been denervated by β -bungarotoxin (Martinez-Monedero et ...with hair cells, but we ...
8
Hair cells, hearing and hopping: a field guide to hair cell physiology in the frog
... auditory hair cells has been much slower in coming, but has benefited greatly by the overall advances made in the field of vertebrate hair cell ...roles hair cells play in sound ...
10
No dramatic age-related loss of hair cells and spiral ganglion neurons in Bcl-2 over-expression mice or Bax null mice
... SGNs, hair cells, die first, followed by withdrawal of the afferent fibers of SGNs, leading to the lack of trophic supports for SGNs ...of hair cells and ...
7
Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape
... By contrast, changes in the distributions of several cytoskeleton- associated proteins were observed during the OHC apical shape transition, both in the area of the cuticular plate and at the heterotypic junctions ...
11
Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization
... V-shaped hair bundles atop auditory hair cells and their uniform orientation are manifestations of epithelial planar cell polarity (PCP) required for proper perception of ...the hair ...
11
Mechanotransduction in mouse inner ear hair cells requires transmembrane channel–like genes
... vestibular hair cells and early postnatal cochlear hair cells lacking TMC1 and TMC2 appear struc- turally normal in scanning electron micro- graphs (Figure 4) but have no detectable ...
15
The Actin-Binding Proteins Eps8 and Gelsolin Have Complementary Roles in Regulating the Growth and Stability of Mechanosensory Hair Bundles of Mammalian Cochlear Outer Hair Cells
... the hair-like bundles that project from the apical surface of cochlear hair ...cells. Hair bundles show a stair-case structure composed of rows of stereocilia, and each stereocilium contains a ...
8
Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain
... murine hair cells and a second PCDH15-CD3 antibody bound to stereocilia more broadly (Ahmed et ...in hair cells, which is localized in proximity to the lower tip-link end (Beurg et ...
11
Degeneration of saccular hair cells caused by MITF gene mutation
... intermediate cells of cochlear SV and a profound hearing loss ...saccular hair cells in MITF-M mutation pigs under SEM micro- ...saccular hair cell loss was still present at the age of E70, ...
9
Differentiation of mammalian vestibular hair cells from conditionally immortal, postnatal supporting cells
... 3g,h). Cells at 39°C possessed many more actin filament bundles, or “stress fibers,” and in most cases a very bright, punctate structure formed close to the center ...ordered hair bundles were not observed, ...
16
Inner ear supporting cells protect hair cells by secreting HSP70
... the hair cells using myosin 7a immunochemistry (Figure ...of hair cells (Figure ...in hair cell ...of hair cells in uninfected utricles (Figure ...supporting cells ...
12
Linear and nonlinear processing in hair cells
... Mechanosensory hair cells in the ear are exquisitely responsive to minute sensory inputs, nearly to the point of ...of hair cells, and their responses to small perturbations that correspond to ...
6
The Ionic Basis of Frequency Selectivity in Hair Cells of the Bullfrog's Sacculus
... THE IONIC BASIS OF FREQUENCY SELECTIVITY IN HAIR CELLS OF THE BULLFROG'S SACCULUS Thesis by Richard Sheridan Lewis In Partial Fulfillment of the Requirements For the Degree of Doctor of Philosophy Cal[.] ...
176
Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish
... Acute copper exposure induces oxidative stress and cell death in lateral line hair cells of zebrafish larvae.. Cisplatin-induced hair cell loss in zebrafish Danio rerio lateral line.[r] ...
53
Recovery of otoacoustic emissions after high level noise exposure in the American bullfrog
... documented hair cell loss in response to a pure tone in five normal (unexposed) ears and seven experimental ears following 20 h exposure to an 800 Hz stimulus at 150 dB ...of hair cell loss as defined by ...
12
A mechanistic framework for auxin dependent Arabidopsis root hair elongation to low external phosphate
... promote hair elongation via elevating intracellular auxin and calcium ...for hair growth to coordinate secretion, endocytosis, and actin dynamics 39 ...root hair tip was transient and dependent on ...
9
Differentiation and transplantation of human induced pluripotent stem cell-derived otic epithelial progenitors in mouse cochlea
... resident hair cells were capable of differentiating into hair ...transplanted cells were able to es- tablish synaptic connections with native SGNs, suggesting the establishment of synaptic ...
15
Dynamics of degeneration and regeneration in developing zebrafish peripheral axons reveals a requirement for extrinsic cell types
... glial cells [27], during devel- opment, but it has yet to be exploited for studies of axon degeneration and ...20 hair cells at its core, surrounded by two types of accessory cells: supporting ...
14
JACKDAW controls epidermal patterning in the Arabidopsis root meristem through a non cell autonomous mechanism
... manner. Cells located in a cleft between two underlying cortical cells become trichoblasts (T cells) that differentiate into root-hair (H) cells, whereas cells positioned over a ...
7