Hair Cells, Auditory
Kif3a regulates planar polarization of auditory hair cells through both ciliary and non ciliary mechanisms
... sensitivity, hair bundles in the cochlea must be uniformly oriented for correct perception of ...the auditory sensory epithelium, the organ of Corti (OC), the vertex of the V-shaped hair bundle on ...
9
Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization
... V-shaped hair bundles atop auditory hair cells and their uniform orientation are manifestations of epithelial planar cell polarity (PCP) required for proper perception of ...the hair ...
11
Sorting nexin 9 (SNX9) is not essential for development and auditory function in mice
... mouse auditory hair cells and might regulate actin polymerization in those ...of auditory hair cells are not affected by Snx9 inactivation, and Snx9 knockout mice have normal ...
12
Seasonal plasticity of auditory hair cell frequency sensitivity correlates with plasma steroid levels in vocal fish
... midshipman auditory physiology (Sisneros, 2009; Sisneros and Bass, 2003) (current study) but little progress has been made in identifying the mechanism(s) of such plasticity except for identifying that it can be ...
12
Condition dependent auditory processing in the round goby (Neogobius melanostomus): links to sex, reproductive condition and female estrogen levels
... how auditory function in the round goby (Neogobius melanostomus), a vocal teleost, co-varied with sex, reproductive condition and female plasma 17β-estradiol ...level. Auditory evoked potentials were ...
10
Sexually dimorphic swim bladder extensions enhance the auditory sensitivity of female plainfin midshipman fish, Porichthys notatus
... closest hair cell bed of the saccular ...and auditory stimulus test trials. The auditory stimuli presented were of equal amplitude (with ±1 – 2 dB) at a given sound level across all frequencies ...
11
Manipulation of BK channel expression is sufficient to alter auditory hair cell thresholds in larval zebrafish
... in auditory hair ...these cells is an outward calcium-activated potassium current that flows through large-conductance calcium- activated potassium (BK) ...change auditory thresholds in fish, ...
9
Hair cells, hearing and hopping: a field guide to hair cell physiology in the frog
... frog auditory system. Information about the physiology of frog auditory hair cells has been much slower in coming, but has benefited greatly by the overall advances made in the field of ...
10
Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear In Vivo
... and hair cell ...ear cells with different specificities and expression levels, depending on the type of adenoviral vectors and the age of ...including auditory hair cells and supporting ...
9
Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea.
... the auditory sensory apparatus, although the highest level occurs before birth and declines towards the onset of hearing (Milo et ...only hair cells that form are found in the vestibular system (Lim ...
19
Growth factor eluting cochlear implant electrode: impact on residual auditory function, insertional trauma, and fibrosis
... protecting auditory hair cells (HCs) against damage caused by intense noise exposure [14,15], drug-induced hearing loss [16], or ischemic injury [17], with no adverse ...
9
Differentiation and transplantation of human induced pluripotent stem cell-derived otic epithelial progenitors in mouse cochlea
... resident hair cells were capable of differentiating into hair ...transplanted cells were able to es- tablish synaptic connections with native SGNs, suggesting the establishment of synaptic ...
15
Stem cells for the replacement of inner ear neurons and hair cells
... stem cells have been used in attempts to replace degenerated auditory ...progenitor cells de- rived from exogenous stem cells were effective in replacing the spiral ganglion neurons in an ...
8
Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain
... murine hair cells and a second PCDH15-CD3 antibody bound to stereocilia more broadly (Ahmed et ...addition, auditory and vestibular function is preserved in PCDH15-DCD1 and PCDH15-DCD3 mice, and ...
11
The Actin-Binding Proteins Eps8 and Gelsolin Have Complementary Roles in Regulating the Growth and Stability of Mechanosensory Hair Bundles of Mammalian Cochlear Outer Hair Cells
... the auditory afferent ...of hair cells to form hair-like bundles ...each hair bundle, the overall size and shape of which depends on location along the cochlea ...
8
Hair cell regeneration in the avian auditory epithelium
... example, two recent studies (Hawkins et al., 2003; Hawkins et al., 2007) used genomic profiling to identify a large number of genes that are altered in the avian auditory and/or vestibular epithelium after HC ...
16
No dramatic age-related loss of hair cells and spiral ganglion neurons in Bcl-2 over-expression mice or Bax null mice
... of auditory neurons -hair cells and SGNs - cannot be delayed by Bax deletion or over-expression of ...of hair cells and SGNs is not dependent on the functions of several key proteins in ...
7
Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice
... outer hair cells (OHCs) of the organ of Corti, which convert mechanical deflections of their actin-rich stereociliary bundles into electrochemical ...frequencies. Auditory hair cells ...
13
Mechanotransduction in mouse inner ear hair cells requires transmembrane channel–like genes
... utricle hair cells are summarized in Figure 5B. In hair cells with intermediate geno- types, we analyzed the 10%–90% operating range of stimulus-response relationships, but found no ...
15
Auditory Dysfunction in Aging: Prospects for Stem Cell Therapy
... exposing cells to various cellular stresses including oxida- tive ...of hair cells and inhibition of potas- sium secretion in strial marginal ...destroy auditory hair cells, ...
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