Half sandwich
Organometallic half sandwich iridium anticancer complexes
... Organoiridium(III) mono- and bis- intercalators with Rigid Bridging Ligands: Synthesis, Cytotoxicity and DNA Binding. J. Inorg. Biochem. 2009, 103, 1405-1414. (d) Wirth, S.; Rohbogner, C.; Cieslak, M.; ...
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Contrasting anticancer activity of half sandwich iridium(III) complexes bearing functionally diverse 2 phenylpyridine ligands
... iridium(III) half-sandwich complexes can exhibit fast rates of ligand exchange 4a,19 in comparison to their non- “ piano stool ” octahedral ...C,N-chelated half-sandwich iridium(III) complexes ...
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Potent half sandwich iridium(III) anticancer complexes containing C∧N Chelated and pyridine ligands
... III half- sandwich compounds is Cl) is often readily substituted by water in aqueous solution (hydrolysis), followed by interaction with biological ...
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Half-sandwich nickel(II) complexes bearing 1,3-di(cycloalkyl)imidazol-2-ylidene ligands
... However, the identity of the active catalyst, which is formed in situ in these reactions, is as yet unknown, and might be a mono- or bis-NHC complex. We therefore decided to prepare and test [NiCl(Cp)(ICy)] (3) (closely ...
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Half sandwich arene ruthenium(II) and osmium(II) thiosemicarbazone complexes : solution behavior and antiproliferative activity
... possess half-sandwich pseudo-octahedral “three- leg piano-stool” structures, with a neutral N,S-chelating thiosemicarbazone ligand and a terminal chloride occupying three coordinative ...
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The preparation and characterisation of rhodium(III) and Iridium(III) half sandwich complexes with napthalene 1,8 dithiolate, acenaphthene 5,6 dithiolate and biphenyl 2,2′ dithiolate
... other half sandwich complexes with Rh–S bond lengths reported by Jin and co-workers ranging from ...for half sandwich rhodium complexes with neutral phosphine ligands ranging from ...
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Design of photoactivatable metallodrugs : selective and rapid light induced ligand dissociation from half sandwich [Ru([9]aneS3)(N–N′)(py)]2+ complexes
... inert half-sandwich Ru(II) compounds of the type [(η 6 -arene)Ru(N-N)(L)] 2+ (where N-N is a nitrogen chelating ligand, L is typically a nitrogen monodentate ligand such as pyridine) with visible light ...
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Varying the flexibility of the aromatic backbone in half sandwich rhodium(III) dithiolato complexes : a synthetic, spectroscopic and structural investigation
... of half sandwich rhodium and iridium complexes (Nejman, Morton-Fernandez, Black, et ...four half sandwich rhodium (III) dithiolato complexes bearing a neutral phosphine ...
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Dicarba closo dodecarborane containing half sandwich complexes of ruthenium, osmium, rhodium and iridium : biological relevance and synthetic strategies
... traditional areas such as Boron Neutron Capture Therapy agents, but also as pharmacophores for the targeting of biologically important proteins and to the development of targeted drugs. The synthetic pathways used for ...
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Half sandwich rhodium(III) transfer hydrogenation catalysts : reduction of NAD+ and pyruvate, and antiproliferative activity
... ([Cp*Ir(phenylpyridine)Cl] and[(p-cym)Ru(bipyrimidine)Cl]) have been shown to oxidise NADH through transfer hydrogenation [13,14, 17,37]. In such processes, the NADH acts as a natural hydride donor, and the metal ...
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The synthesis and unexpected solution chemistry of thermochromic carborane containing osmium half sandwich complexes
... Half-sandwich complexes generally follow the 18-electron rule, although some stable 16-electron (16-e) complexes have been isolated. 1,2 The latter are generally coordinatively unsaturated leading to ...
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Rhodium(III) and iridium(III) half sandwich complexes with tertiary arsine and stibine ligands
... –Cp* half sandwich complexes with arsine and stibine ligands have been prepared and fully characterised by 1 H and 13 C NMR spectroscopy, elemental microanalysis and high resolution mass ...
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The Development of New Routes to Half-Sandwich Metallatricarbadecaborane Complexes, Triflate-Functionalized Polyboranes and Carboranes, and Ammonia Borane Hydrogen Release
... tricarbadecaboranyl half-sandwich complexes. The tricarbadecaboranyl ligands in these complexes exhibit properties distinct from their cyclopentadienyl analogs, including (1) strong electron-withdrawing ...
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Synthesis, Characterization, Electrochemical and Antibacterial Studies of Half-sandwich Ru(II) Complex of 4-fluoro-N-(2-pyridiylmethylene)-aniline Schiff Base
... 14. Sun Ying, Dai Yuan-Chen, Wang Xue, Cheng Jia-Ming and Jia Wei-Guo. Preparation, crystal structures and properties of half-sandwich ruthenium complexes containing salicylbenzoxazole ligands. Journal of ...
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New activation mechanism for half sandwich organometallic anticancer complexes
... The surprising success of these Rh I –fulvene trapping reac- tions under mild conditions of biological relevance is likely to open up new avenues of investigation into reactions of this class of ...
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DFT study of half sandwich bis (tetramethylaluminate) lanthanide complexes
... or half-sandwich complexes have recently attracted considerable attention in organorare-earth metal chemistry ...complexes half-sandwich bis(tetramethylaluminate) lanthanide complexes of the ...
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Transfer hydrogenation and antiproliferative activity of tethered half sandwich organoruthenium catalysts
... The antiproliferative activity of tethered RuII complexes 1−4 against human ovarian A2780, lung A549, hepatocellular HEPG2, breast MCF7, and cisplatin-resistant ovarian A2780Cis cancer c[r] ...
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Rhodium, Iridium, and Ruthenium Half-Sandwich Picolinamide Complexes as Anticancer Agents.
... Ruthenium-para-cymene analogues 10-13 display promising cytotoxicities on HT-29 and MCF-7 cells whereby the most active compound, 12, is more active than cisplatin for HT-29 cells and MC[r] ...
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Chlorido(η6 N2 diphenylphosphanyl N1,N1 diisopropyl 4 methoxybenzamidine κP)(triphenylphosphane κP)ruthenium(II) trifluoromethansulfonate acetone disolvate
... ruthenium(II) half-sandwich piano-stool complexes, see: Therrien & Ward (1999); Faller & D’Alliessi (2003); Cetinkaya et ...ruthenium(II) half-sandwich ...
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Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs
... Half-sandwich ruthenium arene complexes containing iodo and phenylazopyridine ligands (Figure 4f) exhibit remarkable inertness towards ligand substitution in aqueous solution, but are highly toxic in human ...
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