hBD, human β-defensin
Fecal human β-defensin-2 (hBD-2) levels and gut microbiota patterns in preterm neonates with different feeding patterns
... Human β-defensin 2 levels. This study showed that hBD-2 levels in the formula milk predominant group were significantly higher compared with the breast milk only ...Moreover, hBD-2 ...
9
The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production
... hBD: human β-defensin; HDACs: histone deacetylases; HDPs: host defense peptides; HEL: hen egg lysozyme; HIF-1-α: hypoxia-inducible factor 1-α; HLA- DR: human leukocyte antigen-antigen D ...
16
Clinical application of human β defensin and CD14 gene polymorphism in evaluating the status of chronic inflammation
... hBD-1 is a cysteine-rich, cationic antimicrobial peptide with broad-spectrum antimicrobial activity [19]. Thus, rationally, alterations due to genetic polymorphisms at SNP sites may be associated with asthma, ...
10
Isolation of human β-defensin-4 in lung tissue and its increase in lower respiratory tract infection
... -and β -defensins based on the connectivity of their six cystein residues ...[1]. Human β-defensins (hBDs) are expressed mainly in epithelial ...cells. hBD-1 is expressed constitutively in the ...
9
Respiratory epithelial cells require Toll-like receptor 4 for induction of Human β-defensin 2 by Lipopolysaccharide
... α-, β- and the ...neutrophils, β-defensins are produced directly by epithelial cells, and combat infection both through direct microbicidal action and by modulation of cell-mediated immunity ...four ...
11
Host Defense Peptides in Wound Healing
... of hBD-2 is ob- served in keratinocytes, the gastrointesti- nal tract, and the respiratory tract ...(82), hBD-2 can be upregulated directly by bacterial pathogens (62,83) or inflam- matory cells like ...
10
Induction of beta defensin 2 by NTHi requires TLR2 mediated MyD88 and IRAK TRAF6 p38MAPK signaling pathway in human middle ear epithelial cells
... the β-defensin family is one of the most potent innate immune molecules ...multiple β-defensin genes from epithelial and epididymal cells have been identified ...epithelial β- defensins ...
12
Isoleucine, an Essential Amino Acid, Induces the Expression of Human β Defensin 2 through the Activation of the G Protein Coupled Receptor ERK Pathway in the Intestinal Epithelia
... pathogens. Human β-defensin (HBD) is one of the pivotal anti-microbial peptides that are expressed in the colonic ...inducible β-defensin HBD2 by an essential amino acid, ...
8
Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer’s brain
... Mammalian β-defensins are an evolutionarily conserved group of cationic, non-glycosylated antimicrobial and immunomodulatory peptides that are expressed in all mammals, including humans ...pressed human ...
11
Human β defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen specific immunity
... without HBD 2 at the C terminus of the RBD (residues 291–725) of the S1 domain were performed as described previously with minor modifications ...the HBD 2 gene at its 3′ terminus was amplified by ...
12
High level expression of human epithelial β defensins (hBD 1, 2 and 3) in papillomavirus induced lesions
... the defensin family of peptides play important roles in host defense against certain viral infections such as the human immunodeficiency virus (HIV-1), influenza and herpesvi- ruses ...epithelial β- ...
8
Tissue-specific human beta-defensins (HBD)-1, HBD-2 and HBD-3 secretion profile from human amniochorionic membranes stimulated with Candida albicans in a two-compartment tissue culture system
... for HBD-1 to 3, as well as secretory leukocyte protease in- hibitor (SLPI) and ...significantly HBD-2 [16]; 2). Stimulation of FL cells (ATCC CCL-62), a human amnion-derived line with LPS induces up- ...
11
Effects of Stress on Mouse β Defensin 3 Expression in the Upper Digestive Mucosa
... logue hBD-2 is very low in the human stomach during non- Helicobacter pylori infection, suggesting another important antimicrobial mechanism in the ...Furthermore, hBD- 2 expression is much higher in ...
8
Low serum vitamin D levels in type 2 diabetes patients are associated with decreased mycobacterial activity
... other human genes trough VDR-mediated re- sponse elements (Vitamin D Response Elements) and vitamin D inhibits the production of pro-inflammatory cytokines trough MKP-1 pathway ...
9
Expression of human beta defensins 1 and 2 in kidneys with chronic bacterial infection
... JL performed tissue asservation, supervised and coordi- nated all lab methods, junior head of the laboratory, ap- plicant for funding, drafted the manuscript. MR tissue asservation, senior head of the laboratory, ...
10
Download Download PDF
... the human gastrointestinal ...from human breast milk can activate intestinal epithelial cells and promote human beta defensin expression and cytokine ...in human breast ...as ...
9
Ileal antimicrobial peptide expression is dysregulated in old age
... The intestinal microbiota is reported to change with age, although the mechanisms underlying those changes are not fully understood (reviewed in [17]). Given the po- tential disrupting effect of altered AMPP expression ...
5
Keratinocyte Expression of Human β Defensin 2 following Bacterial Infection: Role in Cutaneous Host Defense
... in human skin in response to commensal and pathogenic bacteria suggest that further investigation of the role of CAPs in human skin immunity is warranted and may provide important insights into the ...
6
Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae induced up regulation of human beta defensin 2 in middle ear epithelial cells
... of β-defensin 2 promoter ...of β -defensin 2 (DEFB4) (AF_071216) was isolated by PCR amplification with the following primers: 5'-GAG GTA CCT CCA TCC TTT ACT GTG ATG ATG CC-3' (forward primer ...
10
Structural and functional characterisation of a novel bovine β defensin gene cluster
... B-actin Antimicrobial peptides Activator protein 1 Antigen presenting cell Spermadhesins aqnl Adenosine triphosphate transferase Bovine beta defensin Bovine endometrium cells sperm assoc[r] ...
228