HBeAg seroconversion
<p>Serum Hepatitis B Virus RNA Levels Predict HBeAg Seroconversion and Virological Response in Chronic Hepatitis B Patients with High Viral Load Treated with Nucleos(t)ide Analog</p>
... LAM+ADV and ETV monotherapy was 8.97±1.22 and 9.15±0.92, respectively. After nucleos(t)ide analog (NA) therapy, the serum HBV RNA level decreased steadily in all patients (week 0 vs week 12, p<0.001; week 12 vs week ...
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Longitudinal Study of Hepatitis Activity and Viral Replication before and after HBeAg Seroconversion in Chronic Hepatitis B Patients Infected with Genotypes B and C
... after HBeAg sero- conversion in both patients with subtype Ba and those with genotype C (Table 3) and since patients with subtype Ba had a higher probability of HBeAg seroconversion, it was ...
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High rates of early HBeAg seroconversion and relapse in Indian patients of chronic hepatitis B treated with Lamivudine: results of an open labeled trial
... had HBeAg loss than in those with- out, as seen in previous studies ...of HBeAg seroconversion post treatment ...spontaneous HBeAg seroconversion, frequent relapses were observed in ...
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Serum hepatitis B core antibody levels predict HBeAg seroconversion in chronic hepatitis B patients with high viral load treated with nucleos(t)ide analogs
... Recently, available evidence suggests that patients with chronic HBV infection with high viral load (HVL) are less likely to achieve HBeAg seroconversion and more likely to be associated with high ...
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Serum hepatitis B virus RNA levels as a predictor of HBeAg seroconversion during treatment with peginterferon alfa 2a
... All data were processed using Stata 10.0 software (Stata Corporation, College Station, TX, USA). Categorical var- iables are expressed as number (%), and quantitative var- iables are shown as mean ± standard deviation ...
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<p>Management Of Patients With Hepatitis B Virus Reactivation Post–DAA Treatment Of Chronic Hepatitis C Virus Infection In HCV–HBV Coinfected Patients With Pretreatment HBeAg Seroconversion And Early Degree Of Hepatic Fibrosis</p>
... The study enrolled 140 patients coinfected with HCV – HBV. All patients had HBV PCR ≤ 2,000 IU/mL, normal pretreatment liver enzymes, and showed HBeAg seroconversion with development of HBeAb. In sum, 77 ...
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HBsAg as an important predictor of HBeAg seroconversion following antiviral treatment for HBeAg positive chronic hepatitis B patients
... high HBeAg level is believed to in- duce T-cell tolerance or hyporesponsiveness ...the HBeAg anti- gen level, rather than as a direct effect of any particular ...high HBeAg level and thus ele- vate ...
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Prediction of seroconversion in relation to HBsAG quantification in chronic HBV patients.
... Tenofovir disoproxil fumarate is a nucleotide analogue initially approved for the treatment of HIV infection and later approved for the treatment of chronic hepatitis B in 2008. Tenofovir is structurally similar to ...
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Hepatitis B Precore Protein: Pathogenic Potential and Therapeutic Promise
... by HBeAg and HB- sAg positivity, relatively normal alanine aminotransferase (ALT) levels, and minimal liver damage in spite of very high levels of HBV DNA within the blood and ...as HBeAg positive CHB, ...
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The effects of the insulin resistance index on the virologic response to entecavir in patients with HBeAg-positive chronic hepatitis B and nonalcoholic fatty liver disease
... Results: After 12 weeks of treatment with entecavir, the total virologic response rate in group A was statistically significantly lower than that in group B (P0.05). During weeks 24–96, the difference was not ...
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Original Article Clinical prognosis of chronic hepatitis B patients with concurrent HBeAg/Anti-HBe detection and possible mechanism
... between HBeAg and anti- HBe is a probably explanation for this concurr- ent pattern [30, ...of HBeAg in sera were found: the large HBeAg polypeptides are presented as immune-com- plexes while the ...
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Research Article A Study on Seroconversion in HBeAg Antigen Positive Chronic Hepatitis B Patients with Tenofovir Therapy
... that HBeAg seroconversion was 24% in the HBe Ag reactive group, after a mean duration of 30 ...or HBeAg(-)and at week 144 , 34% of the HBeAg reactive patients had been found lost ...more ...
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Natural history of chronic hepatitis B virus infection from infancy to adult life -the mechanism of inflammation triggering and long-term impacts
... with HBeAg seroconversion; precore 1896 mutant existed in half of childhood HBeAg seroconverters; and genotype C HBV is associated with basal core promotor (BCP) 1762 + 1764 mutations during the ...
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Safety and efficacy of telbivudine for the treatment of chronic hepatitis B
... In the GLOBE trial, the primary outcome was a “therapeutic response” which was defined as a decrease in the HBV DNA level to 5 log copies/mL along with either a loss of HBeAg or ALT normalization. Secondary ...
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HIV seroconversion during pregnancy and the need for pre-exposure prophylaxis (PrEP)
... of seroconversion during pregnancy among women at risk for ...the seroconversion rates for par- ticipants in the Partners in Prevention HSV/HIV Transmis- sion Study showed higher seroconversion risks ...
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Predictors of Liver Disease Severity in Children with Chronic Hepatitis B
... Consecutive treatment-naïve patients with CHB, who underwent a liver biopsy in our tertia- ry health care Department between 2002 and 2012, were included in this retrospective study. The pro- cedure of the biopsy was ...
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Human Coronavirus NL63 and 229E Seroconversion in Children
... months. Seroconversion to HCoV- NL63 positivity during follow-up was seen for 7 of the 13 children ...whether seroconversion to HCoV-229E positivity occurs as frequently as seroconversion to ...
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X-linked Agammaglobulinemia With Normal Immunoglobulin and Near-Normal Vaccine Seroconversion
... We present a 22-month-old boy with X-linked agammaglobulinemia masked by normal immunoglobulin levels and vaccine seroconversion. Diagnosis was made after strong clinical suspicion of immune deficiency led to ...
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Distinct patterns of serum hepatitis B core-related antigen during the natural history of chronic hepatitis B
... We next evaluated the correlation patterns among levels of major viral antigens and nucleic acid in a phase-specific manner. In agreement with a large body of literature, HBV viral antigen and DNA levels exhib- ited high ...
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<p>Comparison of pegylated interferon monotherapy and de novo pegylated interferon plus tenofovir combination therapy in patients with chronic hepatitis B</p>
... Previous study suggested that levels of HBsAg, HBeAg, and HBV DNA in CHB patients treated with PEG-IFN plus entecavir (ETV) were signi fi cantly lower than those treated with ETV monotherapy. 31,33 In addition, ...
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