HCV IRES
A Small Yeast RNA Blocks Hepatitis C Virus Internal Ribosome Entry Site (HCV IRES)-Mediated Translation and Inhibits Replication of a Chimeric Poliovirus under Translational Control of the HCV IRES Element
... on HCV IRES-mediated translation was determined in ...the HCV IRES flanked by chloramphenicol acetyltransferase (CAT) and luciferase genes was used in this ...by HCV ...
11
Structural Determinant of Human La Protein Critical for Internal Initiation of Translation of Hepatitis C Virus RNA
... The HCV IRES RNA bound structure of the LaR2C-N7 structure was determined by NMR spectroscopy. Under bound conditions, the peptide gave several new NOEs and change of value for J for several amide protons ...
12
Hepatitis C Virus Internal Ribosome Entry Site-Dependent Translation in Saccharomyces cerevisiae Is Independent of Polypyrimidine Tract-Binding Protein, Poly(rC)-Binding Protein 2, and La Protein
... abrogate HCV IRES-mediated internal initiation in mammalian cells also prevented  -galactosidase ...on HCV IRES-mediated translation in ...no IRES; ADE3-HCV C120-lacZ: ADE3 ...
12
journal.pone.0072791.PDF
... of HCV IRES-GFP mRNA in the monosome and polysomes fractions in the Huh-7 cells with (+) and without (-) IFN-α and RBV ...of HCV IRES-GFP mRNA in the monosome and polysome fractions by ...
15
Poliovirus proves IRES istible in vivo
... the IRES was changed from that of poliovirus to that of coxsackievirus B (CVB) or HCV ...of IRES activ- ity in cells that normally support poliovirus replication as well as those that ...measuring ...
5
Core Protein-Coding Sequence, but Not Core Protein, Modulates the Efficiency of Cap-Independent Translation Directed by the Internal Ribosome Entry Site of Hepatitis C Virus
... of HCV IRES-directed translation when we expressed the full-length core protein from the recombinant baculovirus AcCACore in HepG2 cells ...in IRES activity in HepG2 cells expressing -galactosidase, ...
12
Mutational Analysis of the GB Virus B Internal Ribosome Entry Site
... the IRES in both the HCV and pestivirus 5 ⴕ ...optimal IRES-mediated translation is dependent on each of the putative RNA hairpins in this domain, including two stem-loops not present in the ...
11
Pestivirus Internal Ribosome Entry Site (IRES) Structure and Function: Elements in the 5′ Untranslated Region Important for IRES Function
... CSFV IRES activity ...for IRES activity is shown by the fact that disruption of 3 bp in this stem severely im- paired IRES activity (21), although compensatory mutations to restore base pairing were ...
10
Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3’ X-tail
... enced HCV IRES-mediated translation we compared the luciferase signal generated from JFH-1 luc trans:NS5B and Con1b luc trans: NS5B (Supplementary data ...the IRES and SL9266 / PK sequences ...
13
RNA-Binding Protein hnRNP D Modulates Internal Ribosome Entry Site-Dependent Translation of Hepatitis C Virus RNA
... augments HCV IRES-dependent translation in ...and IRES-dependent translation in ...the HCV IRES and an effector plasmid, pFLAG-CMV2 (lane 1), and its derivatives expressing hnRNP D ...
12
The duck hepatitis virus 5' UTR possesses HCV like IRES activity that is independent of eIF4F complex and modulated by downstream coding sequences
... the HCV or CSFV ...the HCV or CSFV IRESes depend on the presence of protein-coding sequences downstream of the initiating AUG ...between HCV and CSFV and the heterologous combinations were ...
11
Structure-function analysis of the equine hepacivirus 5′ untranslated region highlights the conservation of translational mechanisms across the hepaciviruses
... EHcV IRES, the 251 CUU 253 -to- 251 GUC 253 mutation within the apical loop (GUC) merely reduced activity to 40–70 % of WT, indicating that the tertiary struc- tures created by this helix are essential regardless ...
14
Differential Effects on the Hepatitis C Virus (HCV) Internal Ribosome Entry Site by Vitamin B12 and the HCV Core Protein
... pHCV1-3/CSFV4 IRES only showed low activity, the remainder of the study was restricted to the CSFV1-3/HCV4 chimeric ...pCSFV1-3/HCV4 IRES func- tioned as an IRES in a bicistronic ...the HCV ...
7
Sequences in the 5′ Nontranslated Region of Hepatitis C Virus Required for RNA Replication
... the IRES are essential for RNA ...for HCV. The region upstream of the IRES contains stem-loop 1 that is formed by nucleotides 5 to 20 and that is separated from stem-loop 2 by a 23-nucleotide-long ...
11
Down regulation of IRES containing 5'UTR of HCV genotype 3a using siRNAs
... of HCV-3a to evaluate their antiviral activity against important domains for translation ...the HCV 3a directed siRNAs for their ability to sup- press the well conserved HCV IRES (5 ’ UTR) ...
9
Structural Features of the Seneca Valley Virus Internal Ribosome Entry Site (IRES) Element: a Picornavirus with a Pestivirus-Like IRES
... The HCV-like IRES elements are found in diverse picornaviruses from multiple genera with differing species and cellular tropisms (3, ...an IRES which is more closely related, at the level of the ...
10
EAW & IRES PARAPHRASING NOV 23
... You should ensure that you capture the goal and mission of UNESCO’s world heritage Organization and list. Lastly, you should identify any[r] ...
64
Coding Sequences Enhance Internal Initiation of Translation by Hepatitis A Virus RNA In Vitro
... The IRES is required for cap-independent, internal ribosome binding and ...the IRES element (for a review, see reference 11), in contrast to the mechanism of ribosome scanning from the capped 59 end of the ...
7
EAW IRES TASK & OUTLINE 12 6
... Thesis The positive nature of this concept can be derived from its impact on international sphere where it helps solve conflicts, simplifies interstate. communications, and also enables[r] ...
46
Factor-Independent Assembly of Elongation-Competent Ribosomes by an Internal Ribosome Entry Site Located in an RNA Virus That Infects Penaeid Shrimp
... an IRES element. Phylogenetic anal- yses have predicted that the IGR IRES elements in dicistrovi- ruses fold into a complex RNA structure that includes three pseudoknots ...an IRES in wheat germ ...
7