HDAC Inhibition
HDAC Inhibition in Lupus Models
... FOR HDAC INHIBITION Studies of human lupus have been aided by the availability of animal mod- els that in many ways resemble the human disease, including autoantibody production and ...
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Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells
... the HDAC inhibition, as noted previously for these compounds, it will be interesting to probe whether histone modifications have a role to play in the observed DNA damage ...to HDAC inhibition ...
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LTR12 promoter activation in a broad range of human tumor cells by HDAC inhibition
... scenario, HDAC inhibitors might impact directly on NF-Y, as suggested by binding of both histone acetyl transferases and HDACs to it [32, ...after HDAC inhibition (Figure 5), while transcriptional ...
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UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells
... 20–24]. Inhibition of UHRF1 leads to decreased DNA methylation and/or repressive histone marks and restor- ation of gene expression [15, 20, ...plus HDAC inhibition reactivates si- lenced genes and ...
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Histone Deacetylase (HDAC) Inhibition as a Novel Treatment for Diabetes Mellitus
... by HDAC inhibition in the neonatal ani- mal but not in the adult animal, where H3K9 dimethylation and extensive DNA methylation locked the Pdx1 pro- moter in its transcriptionally inactive state ...
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HDAC Inhibition and Graft Versus Host Disease
... model, HDAC inhibition in- creased the absolute numbers and pro- portion of Treg cells, primarily in the CD4 + CD25 + Foxp3 + T-cell ...HDACi. HDAC inhibition promoted acetylation of histones ...
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Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition
... of HDAC activity shows that lycroine decreases HDAC enzymatic activities in K562 cells in a dose- dependent ...of HDAC inhibition, we evaluate the cell cycle distribution after lycorine ...
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<p>Combination BET Family Protein and HDAC Inhibition Synergistically Elicits Chondrosarcoma Cell Apoptosis Through RAD51-Related DNA Damage Repair</p>
... and HDAC inhibition also signi fi cantly elevated the ROS level, followed by the activation of cleaved-caspase-3, and the downregulation of Bcl-2 and ...and HDAC inhibition synergis- tically ...
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HDAC inhibition activates the apoptosome via Apaf1 upregulation in hepatocellular carcinoma
... Results: mRNA profiling identified apoptotic protease-activating factor 1 (Apaf1) to be significantly upregulated after HDAC inhibition (HLE siRNA#1/siRNA#2 p < 0.05, HLF siRNA#1/siRNA#2 p < 0.05). As ...
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Survival of primary, but not of cancer cells after combined Plk1- HDAC inhibition
... via inhibition of Cyclin E, Cyclin A/Cdk activity and thus leaving Rb hypo-phosphorylated and sequestering E2F, whose activity is necessary for S phase entry ...
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HDAC inhibition induces HIV-1 protein and enables immune-based clearance following latency reversal
... It is well established that the majority of HIV proviruses harbor defective genomes and, thus, fail to pro- duce replication-competent virus (20). Traditional assays aimed at reservoir characterization measure HIV DNA or ...
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Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras
... Although Ras is known to signal through multiple pathways, the PI3K and MAPK pathways are the most studied and compounds targeting these pathways are in clinical development [2]. However, these compounds are generally ...
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HDAC Inhibition in Rheumatoid Arthritis and Juvenile Idiopathic Arthritis
... why inhibition of HDAC ameliorates experimentally induced ...an HDAC in- hibitor would increase the acetylation of HDAC-1 transcription factors such as NFκB, which would now bind and result in ...
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Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression
... whether HDAC inhibition affected gene expression in any particular ...of HDAC binding to the promoters of genes in CD4 T cells demonstrated that HDAC1, HDAC2, HDAC3 and HDAC6 were bound with ...
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Histone deacetylase activity has an essential role in establishing and maintaining the vertebrate neural crest
... TSA-treated explants at levels consistent with a weakly neuralized state (Fig. 2D), despite the apparent inability of explanted cells to adopt definitive neural fates (Fig. 3A,B). We wondered whether markers of other ...
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1. Mathematical degradation model for transcriptional regulation of brac1
... expected, HDAC inhibition with TSA leads to substantially increased histone H3 and H4 acetylation at the BRCA1 promoter in addition to some alteration in the assembly of HDAC1, BRCA1 and p130, but does not ...
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Original Article Protective effects of histone deacetylase inhibition by Scriptaid on brain injury in neonatal rat models of cerebral ischemia and hypoxia
... Microglial/macrophages are the most impor- tant regulatory cells in the process of innate immune responses in central nervous system injury and disease [20, 32]. The role of microg- lia in the central nervous system ...
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MicroRNA-mediated epigenetic targeting of Survivin significantly enhances the antitumor activity of paclitaxel against non-small cell lung cancer
... and HDAC inhibition promotes ubiquitin-dependent degradation of DNMT1 in breast cancer cells ...synergistic inhibition on DNMT1 was also observed in vitro (Supplementary Figure ...
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Inhibition of histone deacetylase 1 or 2 reduces induced cytokine expression in microglia through a protein synthesis independent mechanism
... which HDAC inhibitors may do this is by suppressing the excessive inflammatory response of chronically activated ...specific HDAC responsible are not fully ...that inhibition of class I HDACs ...
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Combined histone deacetylase inhibition and tamoxifen induces apoptosis in tamoxifen resistant breast cancer models, by reversing Bcl 2 overexpression
... The ability of PCI to induce cell death in Tam- resistant cells when Bcl-2 activity is repressed either genetically or pharmacologically emphasizes the impor- tance of Bcl-2 as a target in Tam resistance. Recent studies ...
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