HDAC inhibitor
Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency
... patients, exposing these cells to 335 nM VOR ex vivo for 6 hours. This VOR exposure models the effects achieved after a 400-mg oral dose (4). Cells were then washed and placed back into the cul- ture. To mimic daily, ...
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Induction of c-Cbl contributes to anti-cancer effects of HDAC inhibitor in lung cancer
... cell proliferation and induced PARP and pro-caspase 3 cleavages (Figure 1B). It also down-regulated EGFR expression (Figure 1B), an important oncoprotein in lung cancer. Since c-Cbl is a tumor suppressor in lung ...
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Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status
... each HDAC inhibitor alone triggered ERK phosphoryl- ation and EGFR expression upregulation in a concentration-dependent manner in AsPC-1 cells at 72 h ...MEK inhibitor compensated for the induced ...
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HDAC inhibitor confers radiosensitivity to prostate stem-like cells
... of TSA was confirmed by western blot using lysates from unsorted cells for acetylated histones where we observed an increase in histone acetylation following treatment (Figure 6B). This is known to correlate with ...
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HDAC inhibitor AR-42 decreases CD44 expression and sensitizes myeloma cells to lenalidomide
... deacetylase inhibitor (HDACi), suberoylanilide hydroxamic acid (SAHA, Vorinostat), was shown to be effective in vitro and to have clinical efficacy in T-cell lymphomas ...proteasome inhibitor, bortezomib ...
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Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy
... Preclinical models suggest that histone deacetylase (HDAC) and mammalian target of rapamycin (mTOR) inhibitors have synergistic anticancer activity. We designed a phase I study to determine the safety, maximum ...
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Efficacious proteasome/HDAC inhibitor combination therapy for primary effusion lymphoma
... proteasome inhibitor, bortezomib (Btz), increased survival relative to that after treatment with ...(HDAC) inhibitor suberoylanilidehydroxamic acid (SAHA, also known as vorinostat) potently ...
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Inhibition of leukemic cells by valproic acid, an HDAC inhibitor, in xenograft tumors
... Acute myeloid leukemia (AML) is the most common malignant myeloid disease in adults, and is a heterogeneous clonal disorder of hematopoietic progenitor cells. The t(8;21)(q22;q22) translocation is one of the most ...
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NAD+-dependent HDAC inhibitor stimulates Monascus pigment production but inhibit citrinin
... To understand the effects of expo- sure to DHC on the production of pigment and citrinin at the molecular level, we analyzed the expression level of MpigA and MpksCT encoding polyk[r] ...
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HDAC inhibitor–dependent transcriptome and memory reinstatement in cognitive decline models
... deacetylase inhibitor vorinostat not only restored spatial memory, but also exerted antiinflammatory action and reinstated epigenetic balance and transcriptional homeostasis at the level of gene expression and ...
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A MEK/PI3K/HDAC inhibitor combination therapy for KRAS mutant pancreatic cancer cells
... of HDAC inhibitors improves the outcome by a factor of at least 100, and just as importantly, only a small proportion of cancer cells ...how HDAC and MEK/PI3K inhibition interact to produce a lethal effect, ...
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PubMedCentral-PMC5161716.pdf
... an HDAC inhibitor to epigenetically regulate gene expression (65, 70) (Figure ...well-established HDAC inhibitor (71, 72), and butyrate target genes in tumors from mice provided a high-fiber ...
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Activity of histone deacetylase inhibitors and an Aurora kinase inhibitor in BCR-ABL-expressing leukemia cells: Combination of HDAC and Aurora inhibitors in BCR-ABL-expressing cells
... of HDAC inhibitors in BCR-ABL-positive cells HDACs have been identified as novel targets for the treat- ment of hematologic malignancies, including Ph-positive ...an HDAC inhibitor, was approved by ...
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HDAC inhibition activates the apoptosome via Apaf1 upregulation in hepatocellular carcinoma
... [5–9]. The histone modification, i.e. acetylation, of lysine residues is an important secondary modification respon- sible for chromatin remodeling and is controlled by his- tone acetyltransferases (HATs) and histone ...
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Effects of the Histone Deacetylase Inhibitor ITF2357 in Autoinflammatory Syndromes
... the HDAC inhibitor ITF2357 in eight pa- tients with autoinflammatory disorders (four patients with Schnitzler syndrome, three with HIDS and one with TRAPS), the effect of the drug was disappointing compared ...
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The histone H4 proteoform dynamics in response to SUV4-20 inhibition reveals single molecule mechanisms of inhibitor resistance
... the HDAC inhibitor (sodium butyrate) nearly abolishes the effects of SUV4-20 inhibition on H4K20me2 in SUM159 ...SUV4-20 inhibitor for 2 h results in a ...with HDAC inhibitor, the ...
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1 Epigenetic targeting of aberrant transcriptional
... (a) H3K27ac profiles in L3.6pl cells at SMAD6, a gene that is downregulated upon treatment with class I HDAC inhibitor (HDACi) showing distal regulatory regions [r] ...
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The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFκB signalling pathway
... the HDAC inhibitor, CHR-3996, has anti-myeloma activity at low concentrations, leading to cell cycle arrest and apoptosis in myeloma cell lines and primary patients ...other HDAC inhibitors have been ...
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Epigenetic Regulation of HIV-1 Latency in Astrocytes
... potent HDAC inhibitor), apicidin (class 1 and class II HDAC inhibitor), and trichostatin A (TSA) (an HDAC inhibitor) all po- tently induced HIV promoter activity ...reversible ...
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HDACiDB: a database for histone deacetylase inhibitors
... (HDAC) inhibitor database (HDACiDB) was constructed to enable rapid access to data relevant to the development of epigenetic modulators (HDAC inhibitors [HDACi]), helping bring precision cancer ...
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