Heart Mitochondria
Membrane potential and delta pH dependency of reverse electron transport-associated hydrogen peroxide production in brain and heart mitochondria
... uncoupler agent) gave rise to a 90% decrease in succinate- driven ROS production in rat heart mitochondria (Korshunov et al. 1997). The other component of pmf, ∆ pH, also appears to have a regulating effect ...
12
Suppression of reactive oxygen species generation in heart mitochondria from anoxic turtles: the role of complex I S nitrosation
... turtle heart. We find that heart mitochondria isolated from turtles acclimated to anoxia produce less ROS than mitochondria from normoxic turtles when consuming ...hypoxic heart and is ...
10
Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states
... Here, we present a 3.3 A resolution structure of complex I from mouse heart mitochondria in the active state (Figure 1). The improved resolution has revealed a nucleotide in the active site of the ...
36
Studies on electron transport and energy linked reactions in beef heart mitochondria and escherischia coli
... Reactivation of NADH oxidation, succinate oxidation and the energy-linked reduction of NADP+ by NADH to pentane extracted particles was achieved by the addition of ubiquinone homologues [r] ...
177
Influence of Tl(+) on the Ca(2+) and Na(+) movement across rat neonatal cardiomyocytes and rat heart mitochondria membranes
... Rat heart mitochon dria were isolated from Wistar adult male rats (200 250 g) according to procedure which explicated more detail in Korotkov et ...containing mitochondria super natant centrifuged for 10 ...
15
The effect of quercetin on oxidative stress markers and mitochondrial permeability transition in the heart of rats with type 2 diabetes
... the heart of rats with type 2 diabetes mellitus ...cardiac mitochondria due to increased aconitase and succinate dehydrogenase activities in rats with type 2 ...in heart mitochondria of ...
9
Effects of guanidine derivatives on mitochondrial function: I Phenethylbiguanide inhibition of respiration in mitochondria from guinea pig and rat tissues
... by mitochondria from several tissues of guinea pigs and rats and observed the effects of phenethylbiguanide on these ...pig heart mitochondria in vitro has been found to exceed the flux of substrate ...
14
Mitochondrial protein synthesis in rainbow trout (Oncorhynchus mykiss) heart is enhanced in sexually mature males but impaired by low temperature
... in mitochondria isolated from the hearts of fish acclimated to 13 °C ...for mitochondria isolated from red muscle of rainbow trout seasonally acclimatized to either 1 or 16 °C (St Pierre et ...isolated ...
11
D-Lactate altered mitochondrial energy production in rat brain and heart but not liver
... and heart, but not liver, mito- chondria demonstrated lower RCR ratios (less than 3) with D-lactate as substrate compared to pyruvate or L- lactate (Table 2 and ...and heart mitochondria but not ...
8
Calcium uptake by mitochondria isolated from muskrat and guinea pig hearts
... A previous study on muskrat, guinea pig and rat heart mitochondria McKean, 1990 also failed to show a difference in respiration rates between interfibrillar and subsarcolemmal mitochondr[r] ...
10
Preventive effect of Zanthoxylum armatum fruit on mitochondrial lipids alteration in isoproterenol-induced myocardial infarcted rats
... the heart and heart mitochondria of normal and experimental ...the heart tissue homogenate and heart mitochondria compared to control rats ...the heart and heart ...
5
EFFECTS OF ANTIBODIES ON MITOCHONDRIA
... Whole serum or reconstituted globulin fractions from antigeninjected rabbits caused a marked diminution in DPNH oxidase activity of the supernatant fluid; compared to tubes incubated wit[r] ...
10
Mitochondria in lung disease
... damaged mitochondria in response to stress or injury (85, 86) is one of the most important mtDAMPs needed to regulate innate immunity (Figure ...dysfunctional mitochondria in response to stress and/or ...
13
The role of mitochondria in aging
... Over the last decade, accumulating evidence has suggested a causative link between mitochondrial dysfunction and major phenotypes associated with aging. Somatic mitochondrial DNA (mtDNA) mutations and respiratory chain ...
8
Mechanism of Energy Transformations in Biological Membranes
... The compressed tight membranes (non- energized configuration of the mem- brane) correspond to the linear forms seen in the mitochondria of canary heart muscle.. The [r] ...
5
Charles Darwin’s Mitochondria
... Charles Darwin suffered illness for most of his adult life with many very differing symptoms. Some of these symptoms were present when he was a university student, both in Edinburgh and Cambridge. In Edinburgh he was ...
5
Mitochondria as signaling organelles
... between mitochondria and the rest of the cell under physiological ...to mitochondria, the redox state of the different electron transport chain complexes and mitochondrial membrane potential ...
7
Mitochondria-targeting theranostics
... on mitochondria-targeting theranostic chemicals, chemical conjugates, or nanosystems is substantially increasing with the significance of subcellular organelle specificity and simultaneous modes of therapy and ...
14
The disruption of mitochondrial axonal transport is an early event in neuroinflammation
... the mitochondria ob- served during neuroinflammation occurred in parallel to the enhanced respiratory function of some mitochon- drial complexes and the production of ATP by the tis- ...axonal mitochondria ...
15
The role of mitochondria in aging
... dysfunctional mitochondria, firm genetic proof that a decline in mitophagy con- tributes to age-dependent mitochondrial dysfunction, much less age-related functional decline, remains ...
10