heart regeneration
In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration
... To examine whether the identified pathways are essential for cardiomyocyte proliferation during heart regeneration, we tested the effects of inhibitors. Animals were treated 6 days after resection of ~20% ...
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Multipotent (adult) and pluripotent stem cells for heart regeneration: what are the pros and cons?
... for heart regeneration as they can be more easily obtained from different sources than other stem cells, expanded ex vivo to yield sufficient numbers and used in autologous or allogeneic fashion for ...
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Migration of cardiomyocytes is essential for heart regeneration in zebrafish
... the heart by blocking Cxcr4 function is not due to delayed CM ...amputated heart by blocking Cxcr4 function is not caused by defects in proliferation or survival of CMs and other ...during heart ...
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Macrophages are required for neonatal heart regeneration
... adult heart, the immune system facilitates scar formation, which repairs the damaged myocardium but compromises cardiac ...the heart can regen- erate fully without scarring following MI; however, this ...
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Can broken hearts be mended? Ken Poss, a pioneer on heart regeneration research
... the Regeneration Next Initiative at Duke University Medical ...tissue regeneration in the zebrafish model system. He discovered heart regeneration in zebrafish, establishing an important model ...
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Dynamic microRNA 101a and Fosab expression controls zebrafish heart regeneration
... normal heart regeneration, wild-type control hearts showed minimal scar tissue and strong Tropomyosin staining within the injured apex, occupying 36% of the total injury site, at the conclusion of a 30-day ...
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Dusp6 attenuates Ras/MAPK signaling to limit zebrafish heart regeneration
... zebrafish heart regeneration, we disrupted Dusp6 using ...patterning, heart, central nervous system, craniofacial and fin formation as FGFs are known to be crucial for the proper development of these ...
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The hippo signaling pathway: implications for heart regeneration and disease
... mouse heart, which causes increased Yap activation, also triggered increased cardio- myocyte proliferation [125], providing further evidence that Hippo signaling restrains adult cardiomyocyte re- ...for ...
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Stimulating ideas for heart regeneration: the future of nerve-directed heart therapy
... tissue regeneration has been demonstrated to be evolutionarily conserved across species, but we are just now starting to understand the role of nerves during mammalian heart ...mammalian heart is ...
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Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration
... the heart is activated by injury and aids muscle regeneration through paracrine effects and as a multipotent cell source, and has received recent attention as a target in cardiac repair ...muscle ...
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Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner
... compromised regeneration of the neonatal heart after injury ...neonatal heart regeneration is ...neonatal heart of NOD/SCID mice that harbor innate immune cells such as macrophages ...
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A p53 based genetic tracing system to follow postnatal cardiomyocyte expansion in heart regeneration
... Cryo-injury surgery was performed in neonates. The mice were first anesthetized by cooling on ice. The skin was sterilized with 75% ethanol, followed by lateral thoracotomy at the fourth intercostal space to expose the ...
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Heart regeneration for clinical application update 2016: from induced pluripotent stem cells to direct cardiac reprogramming
... The heart is composed of various groups of cells, in- cluding blood vessel endothelial cells, smooth muscle cells, nerve cells, and cardiac ...the heart, car- diomyocytes only account for approximately 30 % ...
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Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish
... (control) heart revealing few TUNEL-positive cells. (B) Sham-operated heart, revealing a slight increase in apoptosis in response to pericardial sac rupture at 4 hours post-manipulation (4 ...
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Hippo signaling impedes adult heart regeneration
... that more accurately models human cardiomyocyte loss secondary to coronary artery disease. We performed left anterior descending (LAD) coronary artery occlusion at both P8 and two months of age. In P8 hearts, following ...
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Heart regeneration in adult Xenopus tropicalis after apical resection
... Xenopus tropicalis (female; 12 months old) were treated with Tricaine methanesulfonate bath (MS-222; 1 mg/mL; TCI, Shanghai, China) which was prepared with sterile double distill water at room temperature for 4 min and ...
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tcf21+ epicardial cells adopt non myocardial fates during zebrafish heart development and regeneration
... embryonic heart development and ...myocardial regeneration (Poss et ...during regeneration has not been ...embryonic heart development and adult heart ...
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Hyaluronan and cardiac regeneration
... the heart HA is involved in physiological functions, such as cardiac development during embryogenesis, and in pathological conditions including atherosclerosis and myocardial ...for heart ...
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The ontogeny, activation and function of the epicardium during heart development and regeneration
... These various studies highlight that the heart harbours an endogenous regenerative capacity. While genetic fate mapping studies in neonatal mice and adult zebrafish have shown that the major source of ...
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Regeneration revival? Making housing led regeneration work across England
... The traditional focus for Government intervention in disadvantaged neighbourhoods has been a combination of market failure and equity issues (such as to rectify degraded environments). Some care needs to be applied in ...
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