heat shock protein 40
Changes in the transcriptome of morula-stage bovine embryos caused by heat shock: relationship to developmental acquisition of thermotolerance
... the heat shock protein and antioxidant gene response to heat shock also allowed development to continue normally after ex- posure to ...by heat shock compromise ability of ...
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A gene-specific non-enhancer sequence is critical for expression from the promoter of the small heat shock protein gene αB-crystallin
... by 40%–50% (Figure 2A, numbers 1–4), while mutations in the 10-bp sequence adjoining the HSE inhibit expression by 70%–80% (Figure 2A, numbers 1, 5, and 6; note that mutating the dimeric HSE at −392/−383 did not ...
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Heat Shock Protein 70: Roles in Multiple Sclerosis
... MS is a chronic and progressive neu- rodegenerative disease that is deemed to affect more than 2.1 million people worldwide (21). MS is considered an immune-mediated disease characterized by the presence of inflammatory ...
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Anti-Vpr Activities of Heat Shock Protein 27
... HSP27 activities described in this report are consistent with those of an intrinsic immunity factor targeting Vpr. Indeed, HSP27 is produced in response to Vpr, its expression is modulated by Vpr, it can block ...
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Heat Shock Protein 90 and Heat Shock Protein 70 Are Components of Dengue Virus Receptor Complex in Human Cells
... E protein and the cellular receptor present on the surface of the host ...E protein (9) or the native virion on the cell surface (13); however, it has been suggested that these mole- cules serve primarily ...
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Association of a cellular heat shock protein with simian virus 40 large T antigen in transformed cells.
... To establish whether p73 is related to the hsp70 family of proteins, we attempted to immunoprecipitate the p73/T-ag complexes from cellular extracts of ST803 cells by using a monoclonal [r] ...
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Heat shock protein 90 in neurodegenerative diseases
... ited the mutant LRRK2-elicited toxicity to neurons and rescued the axon growth retardation defect caused by the LRRK2 G2019S mutation in neurons [41]. Mutation of PTEN-induced kinase 1 (PINK1), which encodes a puta- tive ...
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Mitochondrial Heat Shock Protein Machinery Hsp70/Hsp40 Is Indispensable for Proper Mitochondrial DNA Maintenance and Replication
... the 40-kDa family (Table 1) also localize to the mt nucleoid in yeast and human cells (33, 38), and Mdj1 and all three ...of protein substrate (29, ...which protein substrates become available, such ...
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Heat shock factor 1 protein in heat shock factor 1 gene transfected human epidermoid A431 cells requires phosphorylation before inducing heat shock protein 70 production
... Phosphorylation of HSF1 occurs in response to heat (37, 40–42) or inducers of transcriptional activation such as cad- mium and arachidonic acid (35, 43). Although the level of HSF1 phosphorylation is ...
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De novo and rare mutations in the HSPA1L heat shock gene associated with inflammatory bowel disease
... the protein function [42] have been ...HSPA1L protein per- turbs the HSP70 chaperone system dominant negatively by preventing the dimerization [40, 42] and blocks its protective effects to stress in ...
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Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs
... The mechanisms of converting mechanical stress into bio- chemical signals are of growing interest, since several tissues, i.e., blood vessels, are subjected to high shear forces, influenc- ing the metabolism of the ...
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THERMO-TOLERANCE AND HEAT SHOCK PROTEIN OF ESCHERICHIA COLI ATCC 25922 UNDER THERMAL STRESS USING TEST CELL METHOD
... the heat resistance of ...increased heat resistances of E. coli with maximum D-values after heat shock at 45 °C for 5 ...after heat shock treatment was similar to that of ...
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Intracellular protozoan parasites of humans: the role of molecular chaperones in development and pathogenesis
... Expression of Toxoplasma gondii -specific heat shock protein 70 during in vivo. 1326[r] ...
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Pho dynamically interacts with Spt5 to facilitate transcriptional switches at the hsp70 locus
... the protein–protein interaction with ...multiple protein alignment between Pho and YY1, the mouse and human homologue of ...multiple protein alignment ...multiple protein alignment ...
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The heat shock response in neurons and astroglia and its role in neurodegenerative diseases
... disease. Protein inclusions form in discrete areas of the brain characteristic to the type of neurodegenerative disease, and coincide with the death of neurons in that region ...of protein misfolding ...
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1 Roles of Extracellular Vesicles (EVs) carrying HSPs in
... Secreted heat shock protein 90 promotes prostate cancer stem cell 545. heterogeneity[r] ...
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A Child Hereditary Motor Sensory Neuropathy and Mutation of Heat Shock Protein HSPB1
... oligomers to maintain a misfolded protein in a refolding- competent state. The upregulation of HSP27 has been reported to be required for the survival of motor and sensory neurons injured by apoptotic stress. 5 ...
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Nitric oxide induces heat shock protein 70 expression in vascular smooth muscle cells via activation of heat shock factor 1
... expected, heat shock induced HSF1 translocation in SMCs ...in protein level and mobility of HSF1 were observed ...kD protein. NO treatment and heat stress resulted in an increased HSF1 ...
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Heat shock protein expression and apoptosis in myeloid leukaemias
... Mehlen the of et stem cells via apoptosis al., embryonic murine In haemopoietic systems, studies of myeloid differentiation have shown that expression differentiation by is induced hsp70[r] ...
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Response of circulating heat shock protein 70 and anti heat shock protein 70 antibodies to catheter ablation of atrial fibrillation
... Heat shock proteins (HSPs) are characterized as molecu- lar chaperones and have important functions in the pres- ervation and protection of cells and organs from stress and ...
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