heat shock protein 47
Pirfenidone inhibits TGF-β1-induced over-expression of collagen type I and heat shock protein 47 in A549 cells
... We first determined the time course of the TGF-β1 (5 ng/ml) effect on the mRNA expression of collagen type I and HSP47 in A549 cells. The response of colla- gen type I to 5 ng/ml of TGF-β1 was maximal after 6, 12, 24 and ...
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Original Article Role of heat shock protein 47 in epithelial-mesenchymal transition of retinal pigment epithelial cells stimulated by TGF-β2
... Proteins were extracted from ARPE-19 cells and homogenized in lysis buffer containing a cock- tail of protease inhibitors. Protein concentra- tions were measured by the BCA protein assay (Millipore, USA). ...
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Serum heat shock protein 47 levels in patients with drug-induced lung disease
... We recently reported that the expression of HSP47 in autopsied DAD lung specimens of patients with acute ex- acerbation of IPF was greater than that in usual interstitial pneumonia lung specimens of patients with stable ...
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Presence of heat shock protein 47-positive fibroblasts in cancer stroma is associated with increased risk of postoperative recurrence in patients with lung cancer
... abnormal protein folding, and HSP47 has been de- scribed as an important chaperone in the control and maintenance of cellular protein homeostasis ...
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Role of Heat Shock Protein 47 in Transdifferentiation of Human Tenon's Fibroblasts to Myofibroblasts
... Regarding expression of Hsp47 itself, our findings dif- fer from previous reports that documented increased expression of Hsp47 in various extraocular fibrotic dis- eases [12-21]. Increased expression of Hsp47 was even ...
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Serum heat shock protein 47 levels are elevated in acute interstitial pneumonia
... Clinical courses of the various types of idiopathic inter- stitial pneumonias (IIPs) vary widely [1,2]. Although ana- lysis of a surgical lung biopsy has traditionally been the gold standard for the pathological ...
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The expression profiles and prognostic values of HSPs family members in Head and neck cancer
... β-catenin protein and upregulation of Wnt target genes ...survivin protein, but also regulates the mRNA expression of survivin ...called heat shock protein 47 (HSP47), is a ...
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Antisense oligonucleotide inhibition of Heat Shock Protein (HSP) 47 improves bleomycin-induced pulmonary fibrosis in rats
... Tissue Protein Extraction Reagent (Pierce, Rockford, ...for protein content using the BCA Protein Assay Regent (Pierce, Rockford, IL) at an absorbance of 562 ...and protein band concentrations ...
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Nitric oxide induces heat shock protein 70 expression in vascular smooth muscle cells via activation of heat shock factor 1
... the heat shock ...the heat shock response (47, ...resolubilizes protein aggregates that have already formed, and assists in refolding denatured proteins ...
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The Heat Shock Protein Story—From Taking mTORC1,2 and Heat Shock Protein Inhibitors as Therapeutic Measures for Treating Cancers to Development of Cancer Vaccines
... Heat shock protein 90 (HSP90), together with its co-chaperones, can help over 200 nascent polypeptides to fold correctly, eventually leading to synthesis of the proper proteins for constitutive cell ...
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Anti-Vpr Activities of Heat Shock Protein 27
... these cells at 43°C for 30 min. and then transfer them back to 37°C for testing at indicated time intervals. For Western blot analysis, cells were harvested and rinsed with ice-cold HEPES-buffered saline (pH 7.0), then ...
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Heat Shock Protein 70: Roles in Multiple Sclerosis
... prevent protein aggregation and misfolding through their chaperone activity, and on the other hand they can induce antiapoptotic mechanisms (Table ...abnormal protein aggre- gates is a common ...
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Heat shock factor 1 protein in heat shock factor 1 gene transfected human epidermoid A431 cells requires phosphorylation before inducing heat shock protein 70 production
... and protein were deter- ...HSF1–heat shock element complex was significantly increased in both the nucleus and cytosol in HSF1 gene–transfected cells, in- dicating increased synthesis of ...HSF1 ...
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Pho dynamically interacts with Spt5 to facilitate transcriptional switches at the hsp70 locus
... Upon heat shock, HSF, along with P-TEFb, is recruited to chromatin and releases RNA polymerase II from the paused ...the heat shock stimulus, the locus should eventually return to its paused ...
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THERMO-TOLERANCE AND HEAT SHOCK PROTEIN OF ESCHERICHIA COLI ATCC 25922 UNDER THERMAL STRESS USING TEST CELL METHOD
... the heat resistance of ...increased heat resistances of E. coli with maximum D-values after heat shock at 45 °C for 5 ...after heat shock treatment was similar to that of ...
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Intracellular protozoan parasites of humans: the role of molecular chaperones in development and pathogenesis
... Expression of Toxoplasma gondii -specific heat shock protein 70 during in vivo. 1326[r] ...
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Heat shock protein expression and apoptosis in myeloid leukaemias
... Mehlen the of et stem cells via apoptosis al., embryonic murine In haemopoietic systems, studies of myeloid differentiation have shown that expression differentiation by is induced hsp70[r] ...
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A Child Hereditary Motor Sensory Neuropathy and Mutation of Heat Shock Protein HSPB1
... 2. D.J. Lewis-Smith, J. Duff, A. Pyle, H. Griffin, T. Polvikoski, D. Birchall, et al. Novel HSPB1 mutation causes both motor neuronopathy and distal myopathy. Neurol Genet 2016;2: e110. 3. K Maeda , R Idehara , A ...
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Shock the heat shock network
... The targeting of tumors is made possible through establishing protein signatures specific for each cancer type. The recent recognition of the higher expression levels of HSP90 and its accumulation in tumor cell ...
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The Role Of Protective Heat Shock Protein 70 And Proinflammatory Heat Shock Protein 60 Toward The Functional Status Of Acute Thrombotic Ischemic Stroke
... [5] Giffard, R.G., Han, R.Q., Emery, J.F. 2008. Regulation of Apoptotic and Inflammatory Cell Signaling in Cerebral Ischaemia-The complex Roles of Heat Shock Protein 70. Anesthesiology, 2008 August, ...
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