heat shock protein-65
Serum heat-shock protein-65 antibody levels are elevated but not associated with disease activity in patients with rheumatoid arthritis and ankylosing spondylitis
... Objectives: Heat-shock proteins (HSPs) have gained increased interest for their role in auto- immune ...serum heat-shock protein-65 antibody (anti- HSP65) levels and their ...
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Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein 65
... This T cell response to hsp65 in all three groups was significantly higher than that of cells cultured in medium only, suggesting the existence of T lymphocytes specifically reacting to [r] ...
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T Cells Recognize an Immunodominant Epitope of Heat Shock Protein 65 in Kawasaki Disease
... high degree (55%) of homology, with 11 out of 20 amino acids shared between the two se- quences. Hence, this finding suggests the pos- sibility that primary exposure to bacterial HSP65 induces immune activation and ...
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Celastrus aculeatusMerr suppresses the induction and progression of autoimmune arthritis by modulating immune response to heat shock protein 65
... the heat-shock response as the induction of heat-shock proteins is associated with a decrease in NF-κB activity ...of heat-shock protein gene expression by ...
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Inhibition of adjuvant induced arthritis by nasal administration of novel synthetic peptides from heat shock protein 65
... The aim of the present study was to investigate the therapeutic efficacy of synthetic peptides HP-R1, HP-R2 and HP-R3, derived from the sequence of 65-kD mycobacterial heat shock protein[r] ...
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PCR amplification and restriction endonuclease analysis of a 65 kilodalton heat shock protein gene sequence for taxonomic separation of rapidly growing mycobacteria
... A total of 129 reference and clinical strains of rapidly growing mycobacteria (RGM) belonging to 10 taxonomic groups were studied for restriction fragment length polymorphism patterns from a PCR-amplified 439-bp segment ...
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Perforin secreting killer cell infiltration and expression of a 65 kD heat shock protein in aortic tissue of patients with Takayasu's arteritis
... intercellular adhesion molecule-1 in the aortic tissue. Immunohistochemical studies showed that the infiltrating cells mainly consisted of gamma delta T lymphocytes, natural killer cells, macrophages, cytotoxic T ...
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Identification and subspecific differentiation of Mycobacterium scrofulaceum by automated sequencing of a region of the gene (hsp65) encoding a 65 kilodalton heat shock protein
... Recently, automated DNA sequence analysis of a 360-bp segment of the gene (hsp65) encoding a 65-kDa heat shock protein has been used for species assignment of mycobacteria (27). The gene is ...
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Direct Identification of Mycobacteria in Primary Liquid Detection Media by Partial Sequencing of the 65 Kilodalton Heat Shock Protein Gene
... Comparison of mycobacterial isolates identified by biochemical test panels, Accuprobes, and 16S rRNA gene sequencing to direct identification by hsp65 sequencing in primary liquid detect[r] ...
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Exploring the role of Mycobacterium avium subspecies paratuberculosis in the pathogenesis of type 1 diabetes mellitus: a pilot study
... insulin, heat shock protein 60, insulinoma associated proteins (IA-2) and glutamic acid decarboxylase (GAD65) and (b) type 1B which is less frequent and has no known ...a 65 KDa enzyme that ...
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Detection of 65 kD heat shock protein in cerebrospinal fluid of tuberculous meningitis patients
... The 65 kD hsp antigen has received a great deal of atten- tion recently because it appears to be one of the major immunologically active mycobacterial antigens following infection and is expressed at high levels ...
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A gene-specific non-enhancer sequence is critical for expression from the promoter of the small heat shock protein gene αB-crystallin
... Post-natal day 10 rat lens nuclear extracts, which predominantly contain HSF4 [25], were used for these assays. Autoradiograph shows the complex III (lane HSE α B), the major complex, which contains trimeric HSF4, known ...
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Heat shock protein 90 in neurodegenerative diseases
... against protein toxicity, proposing Hsp90 inhibition as a pharmacological intervention to therapeutically increase expression of molecular chaper- one proteins to treat neurodegenerative diseases where aggregation ...
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Regulation and Dynamic Behavior of the Heat Shock Transcription Factor Hsf-1 in C. Elegans
... Most of the evidence for human-specific granules comes from the failure to detect them in mouse or hamster cell lines (Denegri et al., 2002; Sarge et al., 1993). This is not due to divergence of the HSF1 molecule: mouse ...
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Changes in the transcriptome of morula-stage bovine embryos caused by heat shock: relationship to developmental acquisition of thermotolerance
... in heat-shocked embryos; effects of heat shock in vitro [10-13] and heat stress in vivo [14,15] can be reduced in some cases (although not all) [16,17] by admin- istration of ...to heat ...
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Heat shock protein 88 and Aspergillus infection
... Immunoblotting was used to dissect the antibody responses in the sera of 50 patients with proven invasive aspergillosis, 28 patients with suspected invasive aspergillosis, 35 patients wi[r] ...
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Resveratrol and Quercetin: Novel Polyphenolic Chemopreventive Agents
... Anoth shock cells t improv circula surviv Querc malign colon Studie results examp querce focal transc mecha non s (COF) inhibit epithe angiog an ant Althou confirm effects design specif non to of co traditio ...
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Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs
... in protein folding and therefore also in MHC–peptide assembly, its overexpression might influence processing and presentation of synovial cell antigens, possibly leading to a quantitatively and qualitatively ...
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Response of circulating heat shock protein 70 and anti heat shock protein 70 antibodies to catheter ablation of atrial fibrillation
... Heat shock proteins (HSPs) are characterized as molecu- lar chaperones and have important functions in the pres- ervation and protection of cells and organs from stress and ...
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De novo and rare mutations in the HSPA1L heat shock gene associated with inflammatory bowel disease
... the protein function [42] have been ...HSPA1L protein per- turbs the HSP70 chaperone system dominant negatively by preventing the dimerization [40, 42] and blocks its protective effects to stress in the ...
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