Heat shock protein 90
Heat Shock Protein 90-Independent Activation of Truncated Hepadnavirus Reverse Transcriptase
... multifunctional protein critical for several aspects of viral assembly and ...novel protein priming mechanism whereby the RT itself serves as a protein primer and serves as the obligatory ...and ...
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Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics
... Heat shock protein 90 (Hsp90) is essential for the conformational maturation, acti- vation and maintenance of proteins needed for all of the six hallmarks of cancer: angiogenesis, ...
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The Cellular Chaperone Heat Shock Protein 90 Is Required for Foot-and-Mouth Disease Virus Capsid Precursor Processing and Assembly of Capsid Pentamers
... poly- protein, and viral genome ...precursor protein into a pentameric subunit which further encapsidates the ...chaperone heat shock protein 90 (hsp90) impeded FMDV capsid ...
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Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition
... Among the many targeted agents designed to block the activity of oncogenic proteins, inhibitors of the heat shock protein 90 (Hsp90) molecular chaperone are of special interest. These agents ...
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MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma.
... to Heat Shock Protein 90 inhibition in cholangiocarcinoma Andrea Lampis, Pietro Carotenuto, Georgios Vlachogiannis, Luciano Cascione, Somaieh Hedayat, Rosemary Burke, Paul Clarke, Else Bosma, ...
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In Silico Docking Studies of Alkannin and Shikonin with Heat Shock Protein-90 (Hsp90)
... Heat shock proteins (HSPs) stabilise a number of proteins re- quired for tumor ...growth. Heat shock protein 90 (Hsp90) is one of the most common of heat-related ...Hsp90 ...
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X66, a novel N-terminal heat shock protein 90 inhibitor, exerts antitumor effects without induction of heat shock response
... Heat shock protein 90 (HSP90) is essential for cancer cells to assist the function of various oncoproteins, and it has been recognized as a promising target in cancer ...induce heat ...
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Ernst, Anne (2016): Radiotherapy plus heat shock protein 90 inhibition: sensitizing cancer cells to irradiation-induced cell death and enhancing their immunogenicity. Dissertation, LMU München: Medizinische Fakultät
... chaperone heat shock protein 90 (HSP90) and its client proteins ATM, ATR, and NBS1, thereby identifying these candidates as potential biomarkers for radioresistant, aggressive soft tissue ...
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Activity of the Heat Shock Protein 90 Inhibitor Ganetespib in Melanoma
... Heat shock protein 90 (HSP90) is a ubiquitous molecular chaperone that promotes the conformational maturation and stabilization of numerous client ...
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Docking of Human Heat Shock Protein 90 with Selenoderivatives of Geldanamycin
... The heat shock protein 90 (HSP90) is a chaperone protein responsible for matu- ration and activity of a variety of key client proteins involved in cellular proc- esses [1] [2] ...This ...
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Potential prognostic value of heat shock protein 90 in the presence of phosphatidylinositol 3 kinase overexpression or loss of PTEN, in invasive breast cancers
... ribosomal protein S6 are among the most important and representative downstream mole- cules of these signaling pathways ...important protein of the PI3K pathway is the phosphatase and tensin homologue ...
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Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90
... The molecular chaperone heat shock protein 90 (Hsp90) has emerged as an important target for cancer treatment. HDN-1, an epipolythiopiperazine-2, 5-diones (ETPs) compound, was here identified ...
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Original Article Differential expression of heat shock protein 90 isoforms in small cell lung cancer
... Abstract: Heat shock protein 90 (HSP90), a molecular chaperone, plays important roles in cellular protection against various stressful stimuli and in the regulation of cellular growth and ...
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Inhibition of heat shock protein 90 improves pulmonary arteriole remodeling in pulmonary arterial hypertension
... chaperone heat shock protein 90 (HSP90) is involved in a multitude of physiological and pathological processes, its role relating to pulmonary arterial hypertension (PAH) remains ...
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Heat shock protein 90 in neurodegenerative diseases
... cyclin-dependent protein kinase 5; CMA: chaperone-mediated autophagy; CNS: central ner- vous system; DRPLA: Dentatorubral-pallidoluysian atro- phy; FTDP-17: frontotemporal dementia and parkinsonism linked to ...
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Requirement of Heat Shock Protein 90 for Human Hepatitis B Virus Reverse Transcriptase Function
... The initiation of reverse transcription and nucleocapsid assembly in hepatitis B virus (HBV) depends on the specific recognition of an RNA signal (the packaging signal, ) on the pregenomic RNA (pgRNA) by the viral ...
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Heat Shock Protein 90 Is Required for Conidiation and Cell Wall Integrity in Aspergillus fumigatus
... Heat shock protein 90 (Hsp90) is a eukaryotic molecular ...fluorescent protein (GFP) tagging of Hsp90 revealed mainly cytosolic distribution under standard growth ...
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Conserved Water Molecule-dependent Docking Strategy and Atom-Based 3D QSAR Studies to Design Heat Shock Protein 90 Inhibitors
... The protein with ligand having the lowest ionization penalty state was optimized for rendering visual inspection of hydrogen ...the protein–ligand complex was submitted to restrained molecular mechanics ...
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The heat shock protein 90 of Plasmodium falciparum and antimalarial activity of its inhibitor, geldanamycin
... MnCl 2 ), and lysed by pipetting and sonication. The lysate was clarified by centrifugation at 15,000 × g for 20 min in a refrigerated centrifuge. Each reaction sample was pre- pared by mixing 80 µg (by protein ...
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Inhibitory effects of heat shock protein 90 blockade on proinflammatory human Th1 and Th17 cell subpopulations
... Findings: Using anti-CD3 antibody-stimulated human peripheral blood mononuclear cell cultures, we observed that Hsp90 inhibition by non-toxic concentrations of the geldanamycin derivative 17-DMAG significantly blocked T ...
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