Heavy-Chain
Susceptibility to multiple sclerosis is associated with the proximal immunoglobulin heavy chain variable region
... immunoglobulin heavy chain constant (CH) and variable region (VH) polymorphisms were selected to span the entire length of the heavy chain ...
9
Identification of a new mechanism for targeting myosin II heavy chain phosphorylation by Dictyostelium myosin heavy chain kinase B
... Myosin II is a molecular motor that plays a central role in facilitating a broad range of cellular activities in non- muscle cells by driving contraction of actin filaments. In nonmuscle cells, myosin II exists in a ...
9
Gamma heavy chain disease in man Genomic sequence reveals two noncontiguous deletions in a single gene
... A genomic clone was isolated from a human lymphoid cell line which synthesized an NH2- terminally deleted gamma 3 heavy chain disease protein. Nucleotide sequence analysis revealed a normal sequence from ...
10
Myosin Heavy Chain Expression and Oxidative Modifications in Diabetic Rat Hearts
... myosin heavy chain (MHC) isoform transitions, but also reduced amounts in MHC protein; and 2) if diabetes results in declines in the MHC protein content, this change would relate to oxidative damage to ...
9
Clinical and molecular analysis of patients with defects in μ heavy chain gene
... µ heavy chain constant region ...µ heavy chain because it detects patients with homozygous dele- tions, as well as patients with the recurrent splice ...µ heavy chain constant ...
8
Biosynthetic And structural studies of a heavy chain disease protein
... polypeptide chain is absent from the g ...normal heavy chain initiation and a large deletion of the Fd region as being responsible for these two heavy chain disease ...
10
Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes
... cDNA libraries for IgM heavy chain variable regions were prepared from unmanipulated peripheral blood lymphocytes of two healthy people. Partial sequencing of 103 clones revealed VH gene family use and ...
14
Myosin heavy chain gene expression in human heart failure
... myosin heavy chain (MyHC), a and b , ex- ist in the mammalian ventricular myocardium, and their relative expression is correlated with the contractile velocity of cardiac ...
10
Germ line transcription of the immunoglobulin heavy chain locus directs production of mu chain without VDJ
... mu chain protein and mRNA produced by pre-B cell hybrids from normal and X-linked agammaglobulinemic bone ...line heavy chain locus from this LS exon results in transcriptional activation of the JH ...
8
Accumulation and translation of ferritin heavy chain transcripts following anoxia exposure in a marine invertebrate
... ferritin heavy chain mRNA and production of the resulting protein during anoxia in ...ferritin heavy chain mRNA and protein during oxygen deprivation have never before been ...ferritin ...
8
The myosin light chain 1 isoform associated with masticatory myosin heavy chain in mammals and reptiles is embryonic/atrial MLC1
... myosin heavy chain (MHC-M) is expressed as the exclusive or predominant MHC isoform in masseter and temporalis muscles of several rodent species, contrary to the prevailing dogma that rodents express almost ...
10
Identification and Characterization of an Immunogenic Hybrid Epitope Formed by both HIV gp120 and Human CD4 Proteins
... Antigen-antibody docking models generated in silico provide a useful means for obtaining positional information, provided that interpretations are made in the context of immunochemi- cal and biochemical data. The ...
9
Iron Deposition and Ferritin Heavy Chain (Fth) Localization in Rodent Teeth
... cavity. Mammalian ferritins are 24-subunit heteropolymers made of two different subunit types, a heavy and light chain, coded by Fth and Ftl genes respectively. The early embryonic lethality in Fth knockout ...
11
Human myeloma IgG half molecules Catabolism and biological properties
... the heavy chain (Cgamma3) and forms two-chain half-molecules was studied for its in vivo turnover and its ability to fix C1q and hemolytic complement, to bind to human lymphocytes, neutrophils, and ...
8
Design, expression, and testing of a bivalent subunit botulism vaccine for use in cattle
... Johnson S.K., Zhang W., Smith L.A., Hywood-Potter K.J., Todd Swanson S., Schlegel V.L., Meagher M.M. (2003). Scale-up of the fermentation and purification of the recombinant heavy chain fragment C of ...
32
Masticatory (`superfast') myosin heavy chain and embryonic/atrial myosin light chain 1 in rodent jaw closing muscles
... Myosin in striated muscles consists of two high molecular weight heavy chains, MHC, and two pairs of light chains, MLC. There is extensive heterogeneity in the isoform expression of MHC and of MLC among vertebrate ...
9
A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome positive X linked chronic granulomatous disease
... 91-kD chain of this cytochrome result in the X-linked form of chronic granulomatous disease (CGD), in which phagocytes are unable to produce ...polymerase chain reaction and ...
6
Phylogenetic implications of the superfast myosin in extraocular muscles
... myosin heavy chains Ten striated myosin heavy chain genes have been localized in the human genome: the six members of the fast/developmental MYH gene cluster (the embryonic, IIA, IIX, IIB, perinatal ...
13
Characterization of a Macaque Recombinant Monoclonal Antibody That Binds to a CD4-Induced Epitope and Neutralizes Simian Immunodeficiency Virus
... macaque heavy chain immunoglobulin genes, (ii) insert macaque heavy and light chain genes into appropriate eukaryotic expression vectors, and (iii) develop stable transfectants that expressed ...
6
The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin
... aPL heavy chains or light chains to CL binding have yielded conflicting ...the heavy chain [21,45], from the light chain [46], or from both chains ...
10