Hedgehog (Hh) pathway
The hedgehog pathway is a modulator of retina regeneration
... the Hedgehog (Hh) pathway using a potent synthetic and less toxic form of cyclopamine, KAAD (3-keto, N-amino-ethyl aminocaproyl ...the hedgehog pathway enhances the transdifferentiation ...
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Role of canonical Hedgehog signaling pathway in liver
... signaling pathway plays an important role in embryonic ...injuries. Hh signaling is required for liver regeneration, regulates capillarisation, controls the fates of hepatic stellate cells, promotes liver ...
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Targeting glioma stem cells via the Hedgehog signaling pathway
... The Hedgehog (Hh) signaling pathway controls tissue polarity, patterning maintenance, and maintenance of NSCs during embryonic ...the Hh pathway resulting from mutation and deregulation ...
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Drugging Hedgehog: signaling the pathway to translation
... of Hh. Up to this point, in vitro assays of Hh pathway activation had been based either on the differentiation of explanted embryonic tissues or on alkaline phosphatase activity in 10T1/2 cells, an ...
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The Design, Synthesis, and Biological Evaluation of Steroid-Derived Inhibitors of the Sonic Hedgehog Signaling Pathway
... precursor (GNP) cells. This was first shown by Scott and coworkers who deduced that the division of granule cells in the cerebellum was promoted by Sonic Hedgehog released from Purkinje cells. 5 Treating these ...
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The emerging roles of phosphatases in Hedgehog pathway
... Abstract: Hedgehog signaling is evolutionarily conserved and plays a pivotal role in cell fate determination, embryonic development, and tissue ...aberrant Hedgehog signaling is tightly associated with a ...
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Roles for Hedgehog signaling in adult organ homeostasis and repair
... cell-autonomous hedgehog (HH) pathway over-activation: medulloblastoma (MB), rhabdomyosarcoma (RMS) and basal cell carcinoma (BCC) (Ng and Curran, ...aberrant HH (Wong and Reiter, 2011; ...
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SMO PTCH1 GLI1 GLI2 , and GLI3 , were determined in thirty-three
... The hedgehog (HH) pathway is one of the key signaling pathways regulating embryonic patterning, tissue regeneration, stem cell renewal, and cancer growth ...Canonical HH signaling is triggered ...
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A highlight on Sonic hedgehog pathway
... other pathway inhibitors or chemotherapy ...Shh pathway in- hibitors in MB treatment may offer an adequate therapeutic ...Shh pathway is very important during devel- opment, the adverse effect of ...
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Dichotomy in Hedgehog Signaling between Human Healthy Vessel and Atherosclerotic Plaques
... level) HH levels in healthy ves- sels are increased compared with athero- sclerotic ...of HH in plaques is not enough to robustly activate the ...of HH signaling in plaques must constitute inhibition ...
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From inflammation to gastric cancer – the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases
... canonical HH/GLI pathway is activated via bind- ing of the HH ligand to the receptor PTCH ...lysosomes. HH ligand binding is influenced by the presence of distinct co-receptors: growth arrest ...
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... The Hedgehog (Hh) signaling pathway was first identified in the common fruit ...evolutionary pathway of signal trans- mission from the cell membrane to the ...The Hh signaling ...
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The zebrafish iguana locus encodes Dzip1, a novel zinc finger protein required for proper regulation of Hedgehog signaling
... Single zinc-finger domain proteins are not thought to bind DNA, instead they are implicated in mediating protein-protein interactions. The presence of PEST domains in the Dzip1 protein sequence suggests that the protein ...
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Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor
... protein Hedgehog (Hh) (Heberlein and Moses, 1995). Hh induces the transcription factor Atonal (Ato), which promotes the differentiation of R8 photoreceptors posterior to the morphogenetic furrow ...
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Hedgehog signaling stimulates the formation of proliferating Müller glia derived progenitor cells in the chick retina
... The Hh signaling pathway may be important to the formation of ...MGPCs. Hh signaling is known to have many important pleiotropic actions during early eye and retinal development (Dakubo et ...Sonic ...
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Fine tuning of Hh signaling by the RNA binding protein Quaking to control muscle development
... the Hedgehog (Hh) signaling ...the Hh signaling pathway needs to be precisely regulated at different levels, but only a few factors external to the pathway have been ...as ...
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Biochemical mechanisms of vertebrate hedgehog signaling
... Secreted hedgehog (HH) ligands are paracrine signaling factors that mediate communication between cells over distances as large as several hundred microns (Lewis et ...a HH ligand was identified ...
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Repression of Hedgehog signalling is required for the acquisition of dorsolateral cell fates in the zebrafish otic vesicle
... of Hh function does not affect the otic DV and ML axes in zebrafish (Hammond et ...increasing Hh levels by shh mRNA injection causes an expansion of ventromedial (VM) otic territories at the expense of ...
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Review Article Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma
... signaling pathway, shown by the nuclear accumulation of β-catenin, was ob- served in all cases of esophageal BSCC ...the Hedgehog signaling pathway (HHSP) in esophageal BSCC ...epithelial HH ...
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Acute myeloid leukemia – strategies and challenges for targeting oncogenic Hedgehog/GLI signaling
... the HH/ GLI pathway in AML can be a promising therapeutic approach, since this signaling cascade is crucially involved not only in the regulation of cancer stem/leukemia initiat- ing cells, but also in the ...
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