Hedgehog pathway
The hedgehog pathway is a modulator of retina regeneration
... the Hedgehog (Hh) pathway using a potent synthetic and less toxic form of cyclopamine, KAAD (3-keto, N-amino-ethyl aminocaproyl ...the hedgehog pathway enhances the transdifferentiation of RPE ...
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Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer
... targeting hedgehog pathway using antagonists like GANT61 that act downstream of SMO is a more efficient strategy than using antagonists against SMO in breast cancer ...of hedgehog pathway has ...
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Activation of the hedgehog pathway in chronic myelogeneous leukemia patients
... in hedgehog pathway activated basal cell carcinoma (BCC) cells ...signaling pathway in the development and progression of CML, and further studies will be required to under- stand the biological ...
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The emerging roles of phosphatases in Hedgehog pathway
... Abstract: Hedgehog signaling is evolutionarily conserved and plays a pivotal role in cell fate determination, embryonic development, and tissue ...aberrant Hedgehog signaling is tightly associated with a ...
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An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis
... that hedgehog induces BCC transformation via promoting the proliferation and subsequent invagination of cells residing in the basal ...to hedgehog pathway-induced skin tumours, our data show that BCC ...
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Hedgehog pathway as a drug target: Smoothened inhibitors in development
... Preclinical testing of Smo inhibitors has identified tumor types which appear dependent on Hh signaling for their growth, self-renewal, and chemotherapy resistance. Hh signaling does not appear consistent throughout any ...
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Tian, Fei (2013): Effect of the Hedgehog Pathway inhibitor GDC-0449 in lung cancer cells and lung cancer stem cells. Dissertation, LMU München: Medizinische Fakultät
... Hh pathway receptor SMO was found only in SP cells, which indicates the over activity of Hh ...Hh pathway in SP cells would allow the SP cells to promote proliferation, inhibit differentiation and maintain ...
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Ipriflavone attenuates the degeneration of cartilage by blocking the Indian hedgehog pathway
... Hh pathway inhibitors have been identi- fied among 4240 compounds using small molecule screen- ing: (1) ipriflavone, a dietary supplement; (2) tolnaftate, an antifungal agent; (3) and 17-b-estradiol, a human hor- ...
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A highlight on Sonic hedgehog pathway
... Shh pathway is activated, it is necessary that SUFU inhibition of Glis occurs by hyper-phosphorilation of SUFU ...this pathway at several levels [33–39] ...Shh pathway by ubiquitination-related ...
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How Weird is The Worm? Evolution of the Developmental Gene Toolkit in Caenorhabditis elegans
... these Hedgehog-related (Hh-r) gene families and the expansion of the putative receptors known as Patched and the Patched-related (Ptr) genes, there is no canonical Hedgehog pathway in nematodes ...
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The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy
... the Hedgehog pathway in breast cancer The challenge of the basal-like subtype of breast cancer Despite advances in terms of radio-, chemo- and hormonal therapy, 20 to 30% of patients with early breast ...
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... of Hedgehog pathway in the absence of the ...autocrine/juxtacrine Hedgehog signaling. The Hedgehog ligand is secreted by the tumor cell and taken up into the same tumor cell (autocrine manner) ...
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Misactivation of Hedgehog signaling causes inherited and sporadic cancers
... HH pathway, often in nearby mesenchymal cells, by binding to their transmembrane receptors, Patched 1 (PTCH1) and Patched 2 (PTCH2) ...The Hedgehog pathway is critical for the development of diverse ...
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Biochemical pathways and targeted therapies in basal cell carcinoma: A systematic review
... the Hedgehog pathway. Advances in our understanding of hedgehog and other cell signal- ing cascades have resulted in the development of novel drugs in the treatment of human ...
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Investigational agents in metastatic basal cell carcinoma: focus on vismodegib
... available Hedgehog pathway signaling inhibitor of the G-protein coupled receptor-like protein smoothened (SMO) which was approved in the United States on January ...signaling pathway is involved in ...
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Drugging Hedgehog: signaling the pathway to translation
... Hh pathway activation had been based either on the differentiation of explanted embryonic tissues or on alkaline phosphatase activity in 10T1/2 cells, an assay that took over 5 days to complete ...1. ...
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Profile of vismodegib and its potential in the treatment of advanced basal cell carcinoma
... The hedgehog pathway is mutated in virtually all patients with BCC and recent trials with vismodegib, an inhibitor of this pathway, have shown significant ...the hedgehog pathway in the ...
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Gastric cancer and Hedgehog signaling pathway: emerging new paradigms
... The study did not meet the primary endpoint with a no significantly-improved progression-free survival between the placebo group and vismodegib group (9.3 months vs. 11.5; p = 0.34), although with a noticeable tendency ...
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Roles of the Hedgehog Signaling Pathway in Skin Development, Homeostasis and Cancer
... Keywords: Hedgehog signaling; skin; epidermis; hair follicle; development; homeostasis; basal cell.. 20.[r] ...
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Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy
... Sonic Hedgehog (Shh), Indian Hedgehog (Ihh), and Desert Hedgehog (Dhh) – to the transmembrane receptor patched 1 (Ptc1), causing the release of the suppressed transmembrane protein Smoothened (Smo), ...
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