Hemagglutinin esterase
Human Coronavirus HKU1 Spike Protein Uses O-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme
... Human coronavirus (hCoV) HKU1 is one of six hCoVs identified to date and the only one with an unidentified cellular receptor. hCoV-HKU1 encodes a hemagglutinin-esterase (HE) protein that is unique to the ...
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Attachment of Mouse Hepatitis Virus to O-Acetylated Sialic Acid Is Mediated by Hemagglutinin-Esterase and Not by the Spike Protein
... Receptor specificity is a major viral determinant of host preference, cell tropism, and pathogenesis. In coronaviruses (CoVs) (family Coronaviridae, order Nidovirales), which are enveloped, plus-strand RNA viruses of ...
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The Hemagglutinin-Esterase Fusion Glycoprotein Is a Primary Determinant of the Exceptional Thermal and Acid Stability of Influenza D Virus
... glycoproteins: hemagglutinin (HA), which binds to sialylated host cell receptors and mediates membrane fusion, and neuraminidase (NA), which prevents the HA from host cell membrane engagement by cleaving sialic ...
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Expression of Hemagglutinin Esterase Protein from Recombinant Mouse Hepatitis Virus Enhances Neurovirulence
... the hemagglutinin esterase (HE), which is not produced by MHV-A59, a hepatotropic but only mildly neurovirulent ...retained esterase activity or not, resulted in increased viral spread within the ...
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Intrinsic Temperature Sensitivity of Influenza C Virus Hemagglutinin-Esterase-Fusion Protein
... investigated hemagglutinin-esterase-fusion protein (HEF), an influenza C virus glycoprotein ...both hemagglutinin (HA) and neuraminidase (NA) in influ- enza A and B viruses and has three biological ...
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The Acetyl-Esterase Activity of the Hemagglutinin-Esterase Protein of Human Coronavirus OC43 Strongly Enhances the Production of Infectious Virus
... Most betacoronaviruses possess an hemagglutinin-esterase (HE) protein, which appears to play a role in binding to or release from the target cell. Since this HE protein possesses an acetyl-esterase ...
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Hemagglutinin-esterase, a novel structural protein of torovirus.
... One of the most remarkable examples of heterologous re- combination is that of the coronavirus hemagglutinin-esterase (HE) gene. Coronaviruses are enveloped, positive-stranded RNA viruses with a genome of ...
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A DNA Vaccine Expressing Consensus Hemagglutinin-Esterase Fusion Protein Protected Guinea Pigs from Infection by Two Lineages of Influenza D Virus
... IDV has a broad host range. IDV was initially isolated from clinically ill pigs express- ing influenza-like symptoms in 2011 (4). However, subsequently epidemiological data suggest cattle are the primary reservoir (1, 5, ...
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Luxury at a Cost? Recombinant Mouse Hepatitis Viruses Expressing the Accessory Hemagglutinin Esterase Protein Display Reduced Fitness In Vitro
... the hemagglutinin esterase (HE), which possesses sialate-O-acetylesterase activity and which, presumably, promotes virus spread and entry in vivo by facilitating reversible virion attachment to O-acetylated ...
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Lineage specific antigenic differences in porcine torovirus hemagglutinin-esterase (PToV-HE) protein
... Toroviruses (ToV) are enveloped, positive single-stranded RNA viruses of cattle, horses, pigs and humans [1]. They have been associated with enteric infections and diarrhea, especially in young animals and children [2], ...
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Expression and secretion of the bovine coronavirus hemagglutinin-esterase glycoprotein by insect cells infected with recombinant baculoviruses.
... However, murine hepatitis virus MHV strain A59 contains an open reading frame with sequence similarity to both the HE gene of BCV and the HE gene of type C influenza viruses 17, and a va[r] ...
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The Hemagglutinin-Esterase of Mouse Hepatitis Virus Strain S Is a Sialate-4-O-Acetylesterase
... strates (7, 25), we first investigated if the MHV esterase ex- hibits enzymatic activity with fluorescein diacetate or 4-MUAc. Incubation of MHV-S with these substrates clearly resulted in cleavage of substrates ...
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Characterization of monoclonal antibodies to the hemagglutinin esterase glycoprotein of a bovine coronavirus associated with winter dysentery and cross reactivity to field isolates
... Although the WD-associated BCV isolates can be distin- guished from those responsible for neonatal calf diarrhea (NCD) by their clinical syndromes, they appear morphologically and antigenically similar (3, 4, 40). We ...
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Interaction of mouse hepatitis virus (MHV) spike glycoprotein with receptor glycoprotein MHVR is required for infection with an MHV strain that expresses the hemagglutinin-esterase glycoprotein.
... In addition to the spike (S) glycoprotein that binds to carcinoembryonic antigen-related receptors on the host cell membrane, some strains of mouse coronavirus (mouse hepatitis virus [MHV]) express a hemagglu- tinin ...
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Identification of a Coronavirus Hemagglutinin-Esterase with a Substrate Specificity Different from Those of Influenza C Virus and Bovine Coronavirus
... More puzzling is the presence of an HE protein in mouse hepatitis virus (MHV), a virus belonging to the same antigenic cluster as BCV. Initiation of MHV infection is mediated by binding of the spike protein to a cellular ...
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Structure and orientation of expressed bovine coronavirus hemagglutinin-esterase protein.
... An amino acid sequence homology of 30% between the mouse hepatitis coronavirus A59 "HE" protein and the HAl HEI subunit of the hemagglutinin of influenza C virus 28, 29, 32, which also p[r] ...
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Hemagglutinin-esterase-specific monoclonal antibodies alter the neuropathogenicity of mouse hepatitis virus.
... None of these MAbs showed any virus-neutralizing activity in vitro; however, mice passively immunized with the purified MAbs were protected from lethal infection by the JHM strain of mou[r] ...
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The Staphylococcus aureus Methicillin Resistance Factor FmtA Is a d Amino Esterase That Acts on Teichoic Acids
... SXXK for the esterase activity of FmtA, we constructed two vari- ants of FmtA by replacing Ser127 and Lys130 with Ala. By deter- mining the ratios of the observed pseudo-first-order rate con- stants of the mutants ...
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Interaction between the Hemagglutinin Neuraminidase and Fusion Glycoproteins of Human Parainfluenza Virus Type III Regulates Viral Growth In Vivo
... IMPORTANCE Human parainfluenza viruses cause the majority of childhood cases of croup, bronchiolitis, and pneumonia worldwide. Enveloped viruses must fuse their membranes with the target cell membranes in order to ...
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Biophysical Comparison of Two Canine Adenoviruses
... The results of the trypsin digestion experiments Table 1, in which the rapidly sedimenting incomplete soluble hemagglutinin and the slowly sedimenting incomplete soluble hemagglutinin we[r] ...
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