hematological malignancies
Checkpoint inhibitors in hematological malignancies
... Inhibitory molecules such as PD-1, CTLA-4, LAG-3, or TIM-3 play a role to keep a balance in immune function. However, many cancers exploit such molecules to escape immune surveillance. Accumulating data support that ...
16
Intracranial hemorrhage in adult patients with hematological malignancies
... A total of 11 patients underwent craniotomy and hematoma evacuation. Surgical intervention showed a trend of improved 30-day outcome (P = 0.085) in ICH patients with hematological malignancies. Five of the ...
9
RECQ helicases are deregulated in hematological malignancies in association with a prognostic value
... [20]. Hematological malignancies are character- ized by genomic instability that is possibly related to underlying defects in DNA repair of genomic stability ...in hematological cancers compared to ...
9
Invasive Infections Caused by Trichosporon Species and Geotrichum capitatum in Patients with Hematological Malignancies: a Retrospective Multicenter Study from Italy and Review of the Literature
... infections. Hematological diseases, peritoneal dialysis, and solid tumors were the three most com- monly reported underlying diseases or conditions in patients with Trichosporon ...with hematological ...
11
Abnormal microRNA expression in the course of hematological malignancies
... Attempts to identify new prognostic and predictive factors in patients with hematopoietic systemic diseases have been undertaken for many years. Despite many reports on this subject, there is still a need to find new ...
11
Chemotherapy-induced cognitive impairment in hematological malignancies
... Objectives: Chemotherapy-induced cognitive impairment (CICI) is one of the most prominent side effects as it negatively impacts activities of daily life of the affected role. These problems can range from subtle to ...
8
Effects of intensified conditioning on Epstein-Barr virus and cytomegalovirus infections in allogeneic hematopoietic stem cell transplantation for hematological malignancies
... for hematological malignancies ...fractory hematological malignancies with a standard myeloablative (MA) regimen consisting of total body irradiation (TBI)/busulfan (Bu) combined with cyclo- ...
12
MicroRNA-binding site polymorphisms in hematological malignancies
... The non-protein coding parts of the genome have been recognized as key players in the regulation of gene expres- sion. Among various classes of non-coding RNAs, the best known are microRNAs (miRNA), small (~22 ...
6
Hematological malignancies and HBV reactivation: Suggestions for clinical management
... with hematological malignancies, showed that substantial portions of HBV (and HCV) infections present at the time of cancer diagnosis were unknown to patients, and that many had no known risk factors for ...
11
Original Article Efficacy and predictive factors of intravenous itraconazole empirical treatment for patients with hematological malignancies suspected of invasive fungal disease
... Several limitations existed in this study: (1) some pharmaceutical treatments were not recorded in this study, which might resulted in somewhat bias in the results, and it is resulted from that itraconazole has some ...
8
Telomerase reverse transcriptase gene amplification in hematological malignancies
... Our data showed that TERT gene amplification is sig- nificantly associated with hematological malignancies and may play a critical role in carcinogenesis; thus, eluci- dation of their regulatory mechanism ...
9
Histone deacetylase inhibitors: clinical implications for hematological malignancies
... This class of HDACis presents a different structure from the other classes because of the 2′-aminoanilide moiety, which can likely function as a weak zinc-chelating group into the tube-like active site of the deacetylase ...
20
Liver resection for hepatocellular carcinoma in patients with hematological malignancies
... Moreover, antimetabolite drugs may cause methylation of mitochondrial DNA in hepatocytes, resulting in phenotypic changes, and may induce malignant change in hepatocytes leading to subsequent primary hepatocellular ...
7
Molecular functions of metallothionein and its role in hematological malignancies
... Metallothionein (MT) was reported to be a potential negative regulator of apoptosis, and various reports have suggested that it may play roles in carcinogenesis and drug resistance, in at least a portion of cancer cells. ...
8
Molecular study of the perforin gene in familial hematological malignancies
... familial hematological malignancies (call for proposal 2005) and the GenHem- INSERM/DGRS Franco- Tunisian project, and this net- work was supported by the French National Cancer Institute ...of ...
7
Targeting p53 by small molecules in hematological malignancies
... p53, ‘ guardian of the genome’ , was the first tumor suppres- sor gene to be identified in 1979. p53 functions to elimin- ate and inhibit the proliferation of abnormal cells, thereby preventing tumor development [1-4]. ...
9
Evaluation of Pulmonary Manifestations in Hematological Malignancies
... in hematological malignancies” says that, the amount of pleural fluid accumulated in lymphomas may vary, ranging from little or no respiratory symptoms, and blunting of the costophrenic angle on chest ...
102
Evaluating a CLL susceptibility variant in ITGB2 in families with multiple sub types of hematological malignancies
... Here, we examine the ITGB2 variant rs2230531 in an independent cohort of HMs from the Tasmanian Familial Hematological Malignancies Study (TFHMS). Our aim was to follow up the findings of Goldin et al in ...
8
Cancer associated fibroblasts in hematological malignancies
... specific hematological malignancies, a few general considerations can be ...individual hematological malignancies and have been characterized only ...
15
Homoharringtonine and omacetaxine for myeloid hematological malignancies
... Harringtonine and HHT inhibit protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site [16,17]. Re- cent crystallographic studies have shown that HHT ...
10