Hematopoietic lineage
Cells from the hematopoietic lineage are only present transiently during healing in a mouse model of non-severe burn injury
... of hematopoietic lineage have a long-term role in healed tissue is not clear ...of hematopoietic lineage after moderate burn ...all hematopoietic lineage cells and endothelial ...
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Genetic Tracing via DNGR-1 Expression History Defines Dendritic Cells as a Hematopoietic Lineage
... As shown here, Clec9a +/cre Rosa +/EYFP mice will be especially useful for tracing CDP-derived cells during infection and inflam- mation. Clec9a-Cre mice may also be used to manipulate gene expression specifically in ...
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Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points
... All primary hematopoietic cell populations were enriched from 5-to-8-week-old C57BL6 male mice. LSK, CMP, MEP, GMP, CFU-E, ERY, CFU-MK, and iMK populations were collected from bone marrow. Following collection, ...
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The transcription factor ZBP 89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells
... myeloid lineage, and the posterior lateral mesoderm, which forms the ICM (the equivalent of the extraembryonic mammalian yolk sac blood island) just ventral to the notochord, where erythroid development takes ...
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FOXF1 inhibits hematopoietic lineage commitment during early mesoderm specification
... Forkhead box (FOX) transcription factors belong to an evolutionary conserved family of proteins named after the Drosophila forkhead gene whose mutation results in a spiked head phenotype. There are 44 FOX proteins in the ...
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Focal Transcriptional Activity of Murine Cytomegalovirus during Latency in the Lungs
... is hematopoietic lineage, but we must then postulate that the latently infected cells accumulate in organs, are extremely long-lived, and are not replaced during natural turnover by the uninfected cells ...
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Mechanisms regulating stem cell phenotype in infantile hemangioma
... Similarly, hematopoietic activity would be confirmed through function assessment via the formation of BFUs upon TBX2 ...full hematopoietic or endothelial cell ...optimizing lineage induction ...
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Circulating hematopoietic stem cell count is a valuable predictor of prematurity complications in preterm newborns
... complications, but without discrimination between more specific cell phenotype characteristics such as Lin - or CD184 + CD45 + and CD184 + CD45 - [43,45]. These obser- vations were confirmed and extended in the present ...
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Stem cells and repair of lung injuries
... typical hematopoietic lineage, chimeric cells created by fusion, or lung cells gen- erated by transdifferentiation may all play a role in lung repair by promoting the local production of stem cells or ...
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Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells
... Hematopoietic lineage abnormalities of SIRT1-deleted HSCs (Figures 3, 4, and 5; Figures S3–S6; Table S1) were asso- ciated with alterations in the expression of several tran- scription factors implicated in ...
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Nucleated red blood cells impact DNA methylation and expression analyses of cord blood hematopoietic cells
... Under non-pathological conditions, DNA methylation (DNAm) shows great biological differences with tissue and cell type. Clustering of adult blood cells based on their DNAm profiles is consistent with the classical model ...
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Liver Sinusoidal Endothelial Cells Are a Site of Murine Cytomegalovirus Latency and Reactivation
... of hematopoietic origin, ⬃ 40 to 50% of the cells in the NPLC fraction were of the sry ⫹ genotype ...derived hematopoietic lineage NPLCs, including Kupffer cells, liver NK cells, and also hepatic ...
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MEIS2 regulates endothelial to hematopoietic transition of human embryonic stem cells by targeting TAL1
... to hematopoietic transition (EHT), with different molecular markers appearing sequentially during hematopoiesis ...in hematopoietic fate commit- ment and is tightly regulated by extrinsic signals and in- ...
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Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions
... In using the mouse as a model organism for colon cancer, we are making an assumption that the orthologs in both species are functioning in precisely the same way despite ~ 180 MY of independent evolution. We found no ...
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Hematopoietic microenvironment Origin, lineage, and transplantability of the stromal cells in long term bone marrow cultures from chimeric mice
... be hematopoietic cells of the monocyte- macrophage lineage, based upon donor origin, phagocytosis, and expression of specific hematopoietic surface ...
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Current understanding of the administration of mesenchymal stem cells in acute kidney injury to chronic kidney disease transition: a review with a focus on preclinical models
... [27]. Lineage-tracing stud- ies indicated that tubular epithelial cells (TECs) were thought to be the main source of cell regeneration after injury [28, ...
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Rescue of retinal degeneration by intravitreally injected adult bone marrow–derived lineage negative hematopoietic stem cells
... negative hematopoietic stem cells [Lin – HSCs]) containing endothelial precursors stabilizes and rescues retinal blood vessels that would ordinarily completely degenerate, a dramatic neurotrophic rescue effect is ...
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Cord Blood: A Review
... HCT became a standard practice to treat a number of malignant and nonmalignant hematologic diseases. Bone marrow, mobilized peripheral blood, and UCB served as primary sources of cells for HCT. Currently a large number ...
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Embryonic origin of the adult hematopoietic system: advances and questions
... adult hematopoietic system as embryonic ancestors of dHSCs were not detectable owing to the lack of appropriate ...embryonic hematopoietic sites that harbor dHSCs has further complicated the picture of ...
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The stepwise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to Bmp4, activin A, bFGF and VEGF
... definitive hematopoietic precursors, an in vitro process that has been shown to recapitulate the in vivo development of yolk sac hematopoiesis (Keller et ...
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