Heme oxygenase
Intestinal Absorption of Hemoglobin Iron Heme Cleavage by Mucosal Heme Oxygenase
... man. Heme, separated from these hemoproteins by intraluminal proteolysis, is absorbed intact by the intestinal ...absorbed heme is cleaved in the mucosal cell releasing inorganic ...mucosal ...
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A Novel Role for and Potential Therapeutic Targeting of Heme Oxygenase-1 in HIV Neuropathogenesis
... enzyme heme oxygenase-1 (HO-1) is significantly reduced in brain prefrontal cortex of HIV-positive individuals with HIV-associated neurocognitive disorders ...
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Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase 1
... contain heme, which, when released from damaged red blood cells, functions as a potent danger molecule that induces sterile tissue injury and organ ...Free heme is metabolized by heme ...
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Inducible heme oxygenase in the kidney: a model for the homeostatic control of hemoglobin catabolism
... microsomal heme oxygenase as the major enzymatic mechanism for the conversion of hemoglobin-heme to bilirubin-IXa in ...renal heme oxygenase activity may be transiently increased 30- to ...
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Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death
... The oncogenic RAS-selective lethal small molecule Erastin triggers a unique iron-dependent form of nonapoptotic cell death, ferroptosis [19]. A link between heme oxygenase (HO) and iron homeostasis has been ...
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Induction of heme oxygenase-1 protects against nutritional fibrosing steatohepatitis in mice
... Heme oxygenase (HO) is the rate-limiting enzyme for heme degradation in ...of heme into equimolar amounts of biliverdin/bilirubin, carbon monoxide (CO), and free iron ...including heme, ...
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Regulatory role of heme oxygenase-1 in silica-induced lung injury
... Background: Silicosis, a progressive inflammatory lung disease attributed mainly to occupational exposure to silica dust, shows loss of lung function even after cessation of exposure. In addition to conventional ...
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Heme oxygenase-1-mediated neuroprotection in subarachnoid hemorrhage via intracerebroventricular deferoxamine
... the heme from blood spilled into the sub- arachnoid space is metabolized by heme oxygenase (HO), generating excess free iron ...of heme oxygenase-1 (HO-1 or Hmox1) in DFX ...
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The Status of Nitric Oxide and its Backup, Heme Oxygenase 1, in Thromboangiitis Obliterans
... so-called heme oxygenase (HMOX) system (8). Heme oxygenase 1 (HMOX1) is an enzyme that degrades heme into carbon monoxide (CO), biliverdin, and ferrous iron ...
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Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase 1
... as Heme oxygenase-1 (HO-1) and superoxide dismutase 2 (SOD2) are an im- portant defense against ROS-mediated damage [6, ...degrading heme into ferrous iron, carbon monoxide and biliverdin, and ...
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ATF4 dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis
... role of ATF4 in these processes as well as the mechanistic basis for such a role has not been elucidated. Here, we have focused on the specific role that ATF4 plays in metastatic behavior, including migration, invasion, ...
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Heme oxygenase 1 deficiency accompanies neuropathogenesis of HIV associated neurocognitive disorders
... Two heme oxygenase isoforms (HO-1 and HO-2) are expressed to varying levels in nearly all cell lineages, but only HO-1, the rapidly inducible isoform, is considered to be a criti- cal mediator of the ...
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Heme oxygenase 1 is a modulator of inflammation and vaso occlusion in transgenic sickle mice
... The heme content is elevated in sickle organs, which promotes vascular inflammation and heme oxygenase-1 ...increases heme oxygenase-1 expression and inhibits ...
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Inhibition of Heme Oxygenase-1 enhances hyperthermia-induced autophagy and antiviral effect
... by heme oxygenase-1 (HO-1), a stress-inducible cytoprotective protein, limits the efficacy of hyperthermic therapy, for which the exact mechanism remains ...
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The Cytoprotective Enzyme Heme Oxygenase-1 Suppresses Ebola Virus Replication
... infections. Heme oxygenase-1 (HO-1), an enzyme that catalyzes the rate-limiting step in heme degradation, has antioxidative properties and protects cells from various ...
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Identification of heme oxygenase 1–specific regulatory CD8+ T cells in cancer patients
... Treg deficiencies are associated with autoimmunity. Conversely, CD4 + and CD8 + Tregs accumulate in the tumor microenvironment and are associated with prevention of antitumor immunity and anticancer immunotherapy. ...
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Hemodynamic forces induce the expression of heme oxygenase in cultured vascular smooth muscle cells
... of heme catabolism to bili- verdin by heme oxygenase (HO), has many of the same prop- erties as ...the heme moiety of guanylyl cyclase ...substrate, heme, as well as other diverse ...
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Stimulation of heme oxygenase in macrophages and liver by endotoxin
... In rat peritoneal macrophages, engaged in erythrophagocytosis in vitro, endotoxin stimulated heme oxygenase (HO) activity, which was additive to the substrate-mediated enzyme induction produced by the ...
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Characterisation of Anopheles gambiae heme oxygenase and metalloporphyrin feeding suggests a potential role in reproduction
... gambiae heme oxygenase and metalloporphyrin feeding suggests a potential role in reproduction, Insect Biochemistry and Molecular Biology (2018), doi: ...
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Heme oxygenase-1: emerging target of cancer therapy
... Heme oxygenase-1 (HO-1) was initially identified as a liver microsomal protein with activity to degrade heme to bilirubin four decades ago ...kines, heme, hypoxia, nitric oxide, and UV ...
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