Heme synthesis
Staphylococcus aureus Coproporphyrinogen III Oxidase Is Required for Aerobic and Anaerobic Heme Synthesis
... anaerobic heme-dependent ...the heme-deficient ΔcgoX and ΔuroD mutants were unable to grow ...with heme being required for anaerobic growth under these con- ...anaerobic heme-dependent growth ...
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The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation
... affect heme content in HeLa cells because of compensatory mechanisms such as the induction of heme degradation by HO1 (Figure 2, D and ...of heme synthesis by the heme precursor ALA, ...
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Staphylococcus aureus HemX Modulates Glutamyl tRNA Reductase Abundance To Regulate Heme Biosynthesis
... of heme as a cofactor is based on its reactivity, which also results in its toxicity at high ...Excess heme can cause damage to cellular macro- molecules, and the redox cycling of heme-iron produces ...
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HOW ALUMINIUM IS TAKEN U P BY RED BLOOD CELLS: A STUD Y IN RELATION TO H YP OCHROMIC MICROC YTIC ANEMIA IN HEMODIALYZED PATIENTS
... protein in the plasma.' In 1983, the binding of aluminium to human transferrin was reponed by G.Trapp ,md it was then confirmed by a num ber of other researchers throughout the world by using different biochemical ...
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Coordinate expression of heme and globin is essential for effective erythropoiesis
... Heme synthesis requires both porphyrin synthesis and iron ...reducing heme synthesis and improving anemia, and we learned that heme and iron regula- tion is ...reduced ...
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A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors
... of heme as a prosthetic group in proteins and enzymes involved in the transport, storage, and utili- zation of oxygen is well-known ...Furthermore, heme directly regulates the expression of proteins and ...
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The nonerythropoietic component of early bilirubin
... phenobarbital-induced heme protein and cycloheximide-suppressed protein ...450 synthesis showed a minor increase in early labeling when glycine-2- 14 C but not when delta ALA-4- 14 C was used as ...P-450 ...
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ERYTHROID CELL MATURATION AND HEMOGLOBIN SYNTHESIS IN MEGALOBLASTIC ANEMIA
... No population of cells with increasing globin synthesis and decreasing heme synthesis, such as is noted in the primitive erythroid cells of normal subjects cells that appear in the perip[r] ...
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The Inhibitory Effect of Heme on Heme Formation In Vivo: Possible Mechanism for the Regulation of Hemoglobin Synthesis
... 7) Data are presented to show that the effect of hemin is not by a dilution mechanism nor by a decrease in red cell maturation and subsequent release of reticulocytes into the peripheral blood. The findings are discussed ...
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Distinct roles of erythropoietin, insulin like growth factor I, and stem cell factor in the development of erythroid progenitor cells
... supported heme synthesis during erythroid maturation, with little increase in viable cell number or stimulation of DNA ...DNA synthesis, which was greater than that seen with the addition of EP and ...
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Heme Binding and Transfer in the Isd Heme Scavenging Pathway of Staphylococcus aureus
... and heme proteins in ...extract heme from hemoglobin and myoglobin using protein-based extraction pathways that generally isolate and subsequently bind the heme to the amino acid ligands His and Tyr ...
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Staphylococcus lugdunensis IsdG Liberates Iron from Host Heme
... use heme to satisfy its iron require- ment ...of heme are encoded within the ...the heme cofactor, and transport heme into the cell, where it is degraded to release nutrient ...two ...
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A New Approach to Understanding Biological Control of Quinone Electrochemistry
... natural heme cofactor binding in the maquettes as all three of the most common hemes, heme a, heme b and heme c, have now been shown to bind in a single protein, Figure ...natural heme ...
216
Effect of heme arginate administration on blood pressure in spontaneously hypertensive rats
... of heme arginate, a potent inducer of heme oxygenase (EC ...of heme arginate (15 mg/kg body weight for 4 d) resulted in a marked decrease in blood pressure from ...by heme arginate. ...
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A HUMAN HEMOGLOBIN WITH LOWERED OXYGEN AFFINITY AND IMPAIRED HEME HEME INTERACTIONS
... The total hemoglobin concentration was therefore ascertained by three methods: 1 spectrophotometric hemoglobin iron determination after wet ashing 6 and calculation of the pigment concen[r] ...
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An experimental model of postnatal jaundice in the suckling rat Suppression of induced hyperbilirubinemia by Sn protoporphyrin
... compound increased serum bilirubin levels significantly when administered at or after 21 d postnatally. Administration of the synthetic metalloporphyrin, Sn-protoporphyrin, to ALA- treated neonates resulted in a ...
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THE PATHOGENESIS OF ACUTE RENAL FAILURE ASSOCIATED WITH TRAUMATIC AND TOXIC INJURY RENAL ISCHEMIA, NEPHROTOXIC DAMAGE AND THE ISCHEMURIC EPISODE
... It is readily seen in the dissected nephrons, for example, that extensive deposits of extraordinary length of heme pigment and thick casts, either containing or free of heme pigment, may[r] ...
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Developing a Heme Iron Database for Meats According to Meat Type, Cooking Method and Doneness Level
... on heme iron levels within meat types (Tables ...as heme iron is degraded at higher temperatures. The concentration of heme iron at any temperature will depend on the loss of meat mass and the degree ...
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Carbon monoxide stimulates the apical 70 pS K+ channel of the rat thick ascending limb
... of heme on channel activity was also observed in inside-out patches in the presence of ...of heme mediated the ...of heme, had no effect. We conclude that carbon monoxide produced from heme ...
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Tracing heme in a living cell: hemoglobin degradation and heme traffic in digest cells of the cattle tick Boophilus microplus
... efficient heme detoxification mechanisms, in particular hemosomes, should be regarded as an essential aspect of their evolutionary track to ...transport heme to the hemosome may be new, tick-specific ...
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