Hemogenic endothelium
Single cell resolution of morphological changes in hemogenic endothelium
... human hemogenic endothelium We first set out to determine the expression patterns of SOX17 and RUNX1 during human embryonic ...AGM endothelium and associated cell clusters (Jokubaitis et ...human ...
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Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo
... within hemogenic endothelium for HSC formation (Chen et ...knockdown. Hemogenic endothelial expression of Runx1 is governed by an intronic enhancer element that contains consensus sites for Runx, ...
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Hemogenic endothelium specification and hematopoietic stem cell maintenance employ distinct Scl isoforms
... the hemogenic endothelium (Bertrand et ...factors: hemogenic endothelium is first specified by scl-β, the emergence of HSCs from hemogenic endothelium is then controlled by ...
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Cytokine-free directed differentiation of human pluripotent stem cells efficiently produces hemogenic endothelium with lymphoid potential
... Nevertheless, the development of a fully defined system for generation of functional hematopoietic cell types, especially lymphocytes, remains a significant chal- lenge. The identification of molecular mechanisms and ...
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Differentiation of an embryonic stem cell to hemogenic endothelium by defined factors: essential role of bone morphogenetic protein 4
... in hemogenic potential induced by BMP4 of day 4 mesodermal population indicates the existence of two unique populations of endothelial precursors, angioblasts and hemangioblasts ...are hemogenic (20-50%, ...
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Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation
... Hematopoietic stem and progenitor cells (HSPCs) are born from hemogenic endothelium in the dorsal aorta. Specification of this hemato- poietic niche is regulated by a signaling axis using Hedgehog (Hh) and ...
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Hemogenic endothelium generates mesoangioblasts that contribute to several mesodermal lineages in vivo
... ECs in the YS and in the placenta, in a very narrow temporal window (starting at E8.5 or before, progressively decreasing until E10.5 or shortly thereafter) (Fig. 9). Importantly, these extra-embryonic ECs are the only ...
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An in vitro model of hemogenic endothelium commitment and hematopoietic production
... the hemogenic endothelium, was expressed at low levels from ...that hemogenic endothelium differentiation occurred shortly after the onset of ...
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Eilken, Hanna (2009): Blood Generation from Hemogenic Endothelium Proven by Continuous Single Cell Imaging. Dissertation, LMU München: Fakultät für Biologie
... of endothelium are already observable in the developing ...somatopleural endothelium derives from the somatic mesoderm, colonizes the vasculature of the body wall and forms the lymphatic vessels whereas the ...
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Biphasic modulation of insulin signaling enables highly efficient hematopoietic differentiation from human pluripotent stem cells
... genic endothelium development and the formation of ...after hemogenic endothelium induction, one can trigger highly rapid and efficient HSPC formation in monolayer culture, without feeder cells and ...
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Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells
... from hemogenic endothelium is a continuous, several day process extending from ...from endothelium is strictly dependent on a heterodimeric transcription factor composed of a sequence specific ...
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MSX2 suppression through inhibition of TGFβ signaling enhances hematopoietic differentiation of human embryonic stem cells
... of hemogenic endothelium progenitors (HEPs), and generation of hematopoietic progenitor cells (HPCs), which largely mimic embryonic hematopoietic development in vivo ...
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Shear Forces Enhance Toxoplasma gondii Tachyzoite Motility on Vascular Endothelium
... Characterization of T. gondii motility on HUVEC under shear stress conditions. To qualitatively and quantitatively exam- ine parasite migration under flow conditions, a detailed analysis of motility was performed. Under ...
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The Vascular Endothelium and Human Diseases
... The endothelium appears to play a critical role in a variety of human disorders, including peripheral vascular disease, stroke, heart disease, diabetes, insu- lin resistance, chronic kidney failure, tumor growth, ...
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Impact of wall shear stress and ligand avidity on binding of anti-CD146-coated nanoparticles to murine tumor endothelium under flow
... for endothelium-specific targeting by antibody-coated ...to endothelium, these mechanisms are still poorly ...liver endothelium under controlled flow conditions and verified this binding in tumor ...
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Local modulation of pulmonary vascular function
... f endothelium-derived dilators may not mediate hypoxic pulmonary constriction, altered activity o f endothelium-derived constrictor mediators could play an important role in initiating or amplifying smooth ...
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The association between functional and morphological assessments of endothelial function in patients with rheumatoid arthritis: a cross sectional study
... The absence of an association between functional and morphological assessments of the vasculature may be due to a time lag between endothelial dysfunction and subse- quent lesion development. In the study by Hashimoto ...
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Specular Evaluation of Endothelium in Pseudophakic Donor Cornea
... frame / L method and the usage of the image analysis system by computer processing and counting of digitalized endothelial cell images. They insisted that the evaluation of the endothelium was a must at the end of ...
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Interaction between Borrelia burgdorferi and endothelium in vitro
... To determine what effect the integrity of the endothelial monolayer had on spirochete migration into the connective tissue of the amnion, some of the HUVEC monolayers were either physica[r] ...
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Transport of Gold Nanoparticles by Vascular Endothelium from Different Human Tissues
... kidney endothelium in comparison with brain endo- thelium, since endothelial cells primarily determine the rate of entry of nanoparticles into dif- ferent ...
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