Hemophilia A
Rituximab for Treatment of Hemophilia A with High-Responder Inhibitors
... Materials and Methods: This cross sectional study was conducted on ten male patients with severe hemophilia A with inhibitor titer ≥5 Bethesda Units/ml (BU) during 100 weeks in comprehensive hemophilia care ...
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Acquired hemophilia A: emerging treatment options
... Acquired hemophilia A is a rare autoimmune disorder caused by an autoantibody (inhibitor) to factor VIII (FVIII) that interferes with its coagulant function and predisposes to severe, potentially life-threatening ...
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Preimplantation genetic diagnosis of hemophilia A
... Preimplantation genetic diagnosis (PGD) is a powerful tool to tackle the transmission of monogenic inherited disorders in families carrying the diseases from generation to generation. It currently remains a challenging ...
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Past, present and future of hemophilia: a narrative review
... severe hemophilia A patients and in only 3-5% of those with hemophilia B, render replacement therapies ineffective, limit patient access to a safe and effective standard of care and predispose them to an ...
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Detection of Factor VIII Inhibitors in Hemophilia A Patients
... It may be recommended that hemophilia A patients should always be screened for factor VIII inhibitors on regular intervals. Once inhibitors development occurs it is advisable that these patients should be treated ...
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Hemophilia A in Brazil – epidemiology and treatment developments
... Abstract: Hemophilia A is an inherited disorder characterized by deficiency of coagulation factor VIII, which predisposes patients to bleeding ...with hemophilia, for which the public health system provides ...
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Studies of the Metabolism and Distribution of Fibrinogen in Patients with Hemophilia A
... Comparison of these results with those of the previous study in healthy male subjects showed that in patients with hemophilia A the catabolic and synthetic rates of fibrinogen are marked[r] ...
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Challenges and successes in the treatment of hemophilia: the story of a patient with severe hemophilia A and high-titer inhibitors
... severe hemophilia have suffered a substantially reduced quality of life with frequent bleeding episodes, disabling arthropathy, and shorter life ...of hemophilia. By assisting other hemophilia ...
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To study the occurrence of inhibitors in children affected with hemophilia ‘A’ and hemophilia ‘B’ disease
... with hemophilia or had history of recurrent joint ...of hemophilia included in our study, 59 were having positive family history, 40 patients showed negative family history and family history of one patient ...
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ANTI HEMOPHILIC GLOBULIN LEVELS IN CARRIERS OF HEMOPHILIA A
... Therefore, once the normal mean for a reference plasma has been established, Figure 4 may be used to estimate the probability that a potential carrier may be a true carrier at or below a[r] ...
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Consensus recommendations for the diagnosis and treatment of acquired hemophilia A
... tal hemophilia can be predicted from the factor VIII level, and patients predominantly experience hemarthroses, trauma-induced muscle bleeds and other soft tissue ...
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Costs and utilization of treatment in patients with hemophilia
... with hemophilia A, the annual mean healthcare cost was €77,587 for severe patients, €8495 for moderate and €793 for those with mild hemophilia ( P = ...severe hemophilia B had the highest total ...
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Patients Perspective in Plasma Products (Focus on Hemophilia)
... before, hemophilia patients need more attention due to severe hemorrhage and its compli- ...disorder. Hemophilia A was 4304 patients, Hemophilia B 837 patients, von ...
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Comorbidities of cardiovascular disease and cancer in hemophilia patients
... the hemophilia group was retrieved from the Longitudinal Health Insurance Database by matching the birth ...without hemophilia [21]. The data on survey of 2560 USA males with hemophilia A patients ...
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A Preliminary Study of Age and Sex of People with Hemophilia
... (WFH): hemophilia A (HA) and hemophilia B (HB), which are here- ditary X-chromosomal recessive disorders caused by deficiency or absence of coa- gulation factors VIII (encoded by F8) or IX (encoded by F9), ...
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Hemophilia B: Molecular pathogenesis and mutation analysis
... of hemophilia B may be less severe than those of hemo- philia A ...moderate hemophilia A (n = 679) and hemophilia B (n = 123) showed that there was no significant difference in bleeding between ...
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Epidemiology of hemophilia at the Hospital of Rabat:About 263 cases
... Hemophilia is a bleeding disorder inherited as constitutional a recessive X-linked, due to a deficiency of factor VIII (hemophilia A) or factor IX (hemophilia B) of coagulation. This condition is the ...
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Current animal models of hemophilia: the state of the art
... to hemophilia A mice, hemophilia B mice do not show spontaneous bleeding, but will bleed and die after tail clipping unless the wound is ...cauterized. Hemophilia B mice have been used to test the ...
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Emerging and future therapies for hemophilia
... modified antibody designed to replace the cofactor function of FVIII by bringing FIXa and FX into approximate orienta- tion for rapid conversion of FX to FXa. The mode of action is nonclotting factor replacement of FVIII ...
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Treatment adherence in hemophilia
... of hemophilia-treatment centers (HTCs; the International Hemophilia A Practice Patterns Survey), rates of hemophilia A prophylaxis prescrip- tion (sum of primary, secondary continuous, and secondary ...
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