Hemorrhagic Transformation
Frequency and determinants for hemorrhagic transformation of posterior cerebral stroke
... 24. Tu HT, Campbell BC, Christensen S, Desmond PM, DA De Silva, Parsons MW, Churilov L, Lansberg MG, Mlynash M, Olivot JM, Straka M, Bammer R, Albers GW, Donnan GA, Davis SM, EPITHET-DEFUSE Investigators. Worse stroke ...
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Original Article The effects of let7i on cerebral edema and hemorrhagic transformation after thrombolysis by rt-PA
... Abstract: Thrombolysis by recombinant tissue plasminogen activator (rt-PA) damages the blood-brain barrier (BBB), causing cerebral edema and hemorrhagic transformation (HT). However, the mechanism behind ...
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Paradoxical effect of obesity on hemorrhagic transformation after acute ischemic stroke
... In the present study it was observed that as increasing of obesity severity, the proportion of cardioembolic stroke and severe stroke (reflected by initial NIHSS score) de- creased, despite of the elevated prevalence of ...
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Is the serum ferritin level a considerable predictor for hemorrhagic transformation of ischemic stroke?
... Hemorrhagic Transformation (HT) of Is- chemic Stroke (IS) is a relatively frequent complication occurring in 2.2% to 44% of clinical cases (1). HT is related to poor prognosis of patients with IS. ...
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The hemorrhagic transformation index score: a prediction tool in middle cerebral artery ischemic stroke
... Asymptomatic hemorrhagic transformation; AIS: Acute ischemic stroke; ALT: Alanine transaminase; APTT: Activated partial thromboplastin time; ASPECTS: Alberta Stroke Program Early CT score; AST: Aspartate ...
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Blood pressure variability and hemorrhagic transformation after intravenous thrombolysis in acute ischemic stroke
... The hemorrhagic transformation was classified using clinical and radiological criteria as follows: hemorrhagic transformation (HT), parenchymal hemorrhage (PH), and symptomatic hemorrhage ...
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LDL-Cholesterol in Relation to Mortality of Intracerebral Haemorrhage and Hemorrhagic Transformation of Large Artery Thrombotic Stroke
... occlusion. Hemorrhagic infarctions comprise most of the remainder of strokes, with a smaller number due to aneurysmal subarachnoid ...develop hemorrhagic transformation within 1 week after ...
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Prediction of Hemorrhagic Transformation in Acute Ischemic Stroke: Role of Diffusion Weighted Imaging and Early Parenchymal Enhancement
... therapy. Various clinical risk factors for hemorrhagic transformation (HT) in acute ischemic stroke have been documented (4 –11). In the European Cooper- ative Acute Stroke Study I trial, the large extent ...
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Association of CT Perfusion Parameters with Hemorrhagic Transformation in Acute Ischemic Stroke
... Nonparametric analysis was performed to compare cases and controls by using the Wilcoxon rank sum test. For the initial anal- ysis, all patients with endovascular therapy were excluded. CTP parameters were compared for ...
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Highly glycosylated CD147 promotes hemorrhagic transformation after rt-PA treatment in diabetes: a novel therapeutic target?
... Diabetes mellitus (DM) has become a worldwide health challenge as the number of DM patients has reached 415 million and may grow up to 642 million by 2040 [1]. DM substantially increases the risk of first ischemic stroke ...
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Increased hemorrhagic transformation and altered infarct size and localization after experimental stroke in a rat model type 2 diabetes
... During focal cerebral ischemia, damage to cerebral blood vessels occurs early and in a progressive fashion [5]. Reperfusion through damaged cerebral blood vessels is likely to further increase the ultimate tissue damage ...
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Blood Brain Barrier Permeability Assessed by Perfusion CT Predicts Symptomatic Hemorrhagic Transformation and Malignant Edema in Acute Ischemic Stroke
... ⫽ hemorrhagic transformation; ICA ⫽ internal carotid artery; IA ⫽ intra-arterial; INR ⫽ international normalized ratio; IV ⫽ intravenous; MCA ⫽ middle cerebral artery; ME ⫽ malignant edema; MMP-9 ⫽ matrix ...
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The glucagon-like peptide-1 receptor agonist exendin-4 ameliorates warfarin-associated hemorrhagic transformation after cerebral ischemia
... Background: As the number of patients with cardioembolic ischemic stroke is predicted to be double by 2030, increased burden of warfarin-associated hemorrhagic transformation (HT) after cerebral ischemia is ...
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Influences of blood lipids on the occurrence and prognosis of hemorrhagic transformation after acute cerebral infarction: a case-control study of 732 patients
... The exact pathogenesis of lipid-related HT after ACI is not yet established. Adequate lipid levels affect the vascu- lature and are essential for maintaining normal membrane fluidity and the integrity of vessels and ...
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Original Article Apparent diffusion coefficient value for prediction of hemorrhagic transformation in acute ischemic infarction
... Hemorrhagic transformation (HT), which refers to secondary bleeding into the ischemic cere- bral area after stroke, is a serious complication [2, ...
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Dynamic change of neutrophil to lymphocyte ratio and hemorrhagic transformation after thrombolysis in stroke
... worsening. Hemorrhagic events were categorized as symptomatic intracranial hemorrhage (sICH) and parenchymal hematomas (PH) according to previously published ...
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Comparison of CT and Three MR Sequences for Detecting and Categorizing Early (48 Hours) Hemorrhagic Transformation inHyperacute Ischemic Stroke
... blood volume by converting petechiae into an artifactual clotlike hematoma, as in the case illustrated by Figure 1. Thus far, the combination of EPI-GRE T2*-weighted imaging with another less susceptibility-sensitive se- ...
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MR Imaging Enhancement Patterns as Predictors of Hemorrhagic Transformation in Acute Ischemic Stroke
... In this study, we demonstrated that early parenchy- mal enhancement, as demonstrated on MR images obtained during the hyperacute stage (within 7 hours of ischemic stroke onset), was significantly associated with ...
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Blood–brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke
... A 39-year-old woman underwent left internal carotid artery (ICA) blood–brain barrier disruption (BBBD) (A), with (as expected) resultant left-sided cortical enhancement on contrast-enhan[r] ...
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Measuring Elevated Microvascular Permeability and Predicting Hemorrhagic Transformation in Acute Ischemic Stroke Using First Pass Dynamic Perfusion CT Imaging
... B olus-chase perfusion imaging 1-10 uses dynamic contrast- enhanced data to produce parametric color overlay maps of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time or time of local peak ...
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