Hendra Virus
Beyond Anchoring: the Expanding Role of the Hendra Virus Fusion Protein Transmembrane Domain in Protein Folding, Stability, and Function
... the Hendra virus F TMD is an important regulator of TMD- TMD interactions and show that these interactions help hold HRB in place prior to the triggering of membrane ...
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Membrane Fusion Tropism and Heterotypic Functional Activities of the Nipah Virus and Hendra Virus Envelope Glycoproteins
... Nipah virus (NiV) and Hendra virus (HeV) are novel paramyxoviruses from pigs and horses, respectively, that are responsible for fatal zoonotic infections of ...vaccinia virus system and a ...
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Natural Hendra virus infection in flying-foxes - tissue tropism and risk factors
... Hendra virus (HeV) is a lethal zoonotic agent that emerged in 1994 in Australia. Pteropid bats (flying-foxes) are the natural reservoir. To date, HeV has spilled over from flying-foxes to horses on 51 known ...
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Climate change could increase the geographic extent of Hendra virus spillover risk
... Hendra virus (HeV, Paramyxoviridae:Henipavirus) is another bat-borne virus that spills over into domestic animals, in its case horses, and then people with high case fatality rates of 50–75% (Halpin ...
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Side Chain Packing below the Fusion Peptide Strongly Modulates Triggering of the Hendra Virus F Protein
... Nipah virus F protein; generously provided by Chris Broder [Uniformed Services University of the Health Sci- ...pCAGGS-Hendra virus F and G and T7 luciferase were overlaid with target BSR cells on ...
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Mutations in the Transmembrane Domain and Cytoplasmic Tail of Hendra Virus Fusion Protein Disrupt Virus-Like-Particle Assembly
... ABSTRACT Hendra virus (HeV) is a zoonotic paramyxovirus that causes deadly ill- ness in horses and ...of virus-like particles (VLPs) that were morphologically and physically distinct from M-only or ...
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Single Amino Acid Changes in the Nipah and Hendra Virus Attachment Glycoproteins Distinguish EphrinB2 from EphrinB3 Usage
... Nipah virus (NiV) and Hendra virus (HeV), are lethal emerging ...reporter virus (NiVpp) entered ephrinB3-expressing cells much more efficiently than did HeV pseudotyped particles (HeVpp), and ...
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Inhibition of Hendra Virus Fusion
... Our experimental results, combined with computational modeling of the possible interactions of the HPIV3 peptide with the 6HB region of the HeV F protein, suggest a distinct balance of structural features on the HPIV3 ...
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The Exceptionally Large Genome of Hendra Virus: Support for Creation of a New Genus within the FamilyParamyxoviridae
... in Hendra, a suburb of Brisbane, Australia, in September 1994 resulted in the deaths of 14 racing horses and a horse ...The virus was originally called Equine morbillivirus but was renamed Hendra ...
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Receptor Binding, Fusion Inhibition, and Induction of Cross-Reactive Neutralizing Antibodies by a Soluble G Glycoprotein of Hendra Virus
... Two newly recognized and closely related paramyxoviruses have been identified from cases of severe respiratory and en- cephalitic diseases in animals and humans; these viruses are known now as Hendra virus ...
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Cathepsin L Is Involved in Proteolytic Processing of the Hendra Virus Fusion Protein
... the proteolytic processing of Hendra virus F. Twenty-four hours after cell sorting, shRNA-expressing Vero cells were transiently transfected with pCAGGS-Hendra F or -SV5 F. Metabolic labeling and ...
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Dimeric Architecture of the Hendra Virus Attachment Glycoprotein: Evidence for a Conserved Mode of Assembly
... zoonotic Hendra virus (HeV) uses the flying fox as a natural host and is highly virulent in humans and ...Nipah virus (NiV) which, in its largest outbreak, was respon- sible for the death of ...
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Electrostatic Interactions between Hendra Virus Matrix Proteins Are Required for Efficient Virus-Like-Particle Assembly
... ABSTRACT Hendra virus (HeV) is a zoonotic paramyxovirus belonging to the genus ...disease virus (NDV) M and is fundamental to protein stability and effective virus-like- particle (VLP) ...
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Residues in the Stalk Domain of the Hendra Virus G Glycoprotein Modulate Conformational Changes Associated with Receptor Binding
... Hendra virus (HeV) and Nipah virus (NiV) are two newly emergent zoonotic viruses which currently comprise their own genus, Henipavirus, within the family ...
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Endocytosis Plays a Critical Role in Proteolytic Processing of the Hendra Virus Fusion Protein
... Biotinylation of cell surface proteins. Surface biotinylation was performed following transient transfection of Vero cells with wt or mutant Hendra virus F and radiolabeling. Cells were placed on ice and ...
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Difficulties experienced by veterinarians when communicating about emerging zoonotic risks with animal owners: the case of Hendra virus
... Since this study was undertaken, some of the issues have been addressed by government agencies through the Intergovernmental Task Force, professional peak bodies and the National Hendra Virus Research ...
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Residues in the Hendra Virus Fusion Protein Transmembrane Domain Are Critical for Endocytic Recycling
... using Hendra virus F antipep- tide antibodies and protein A-conjugated Sepharose beads (Amer- sham/GE Healthcare Bio-Sciences, Piscataway, ...of Hendra virus F, protein A Sepharose beads were ...
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Climatic suitability influences species specific abundance patterns of Australian flying foxes and risk of Hendra virus spillover
... Hendra virus is a paramyxovirus of Australian flying fox bats. It was first detected in August 1994, after the death of 20 horses and one human. Since then it has occurred regularly within a portion of the ...
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Hendra virus: what do we know?
... incubating Hendra virus but not yet showing clinical ...of Hendra virus to avoid unnecessary exposure and to instigate appropriate infection control procedures as described in Guidelines for ...
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Survival of Hendra Virus in the Environment: Modelling the Effect of Temperature
... Abstract: Hendra virus (HeV), a highly pathogenic zoonotic paramyxovirus recently emerged from bats, is a major concern to the horse industry in ...lower virus survival rates in the ...simulated ...
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