Heparan Sulfate Proteoglycans
Heparan sulfate proteoglycans: heavy hitters in the angiogenesis arena
... Editor Heparan sulfate proteoglycans Without new blood vessels, neoplasms cannot expand beyond a few millimeters, the point at which the diffu- sion of nutrients and the disposal of waste products ...
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The interaction of heparan sulfate proteoglycans with the amyloid β protein.
... Summary Heparan sulfate proteoglycans and Aß In humans suffering from Alzheimer's disease (AD), heparan sulfate proteoglycans (HSPG) are found in close association with amyloid ß ...
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Characterization of Hepatitis C Virus Interaction with Heparan Sulfate Proteoglycans
... Together, these data indicate that HCV hijacks apolipoprotein E to initiate its interaction with specific HS structures. IMPORTANCE Hepatitis C is a global health problem. Hepatitis C virus (HCV) infects approximately ...
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Different Heparan Sulfate Proteoglycans Serve as Cellular Receptors for Human Papillomaviruses
... While heparan sulfate proteoglycans (HSPGs) mediate initial binding to the cell surface, the class of proteins carrying heparan sulfates has not been ...of heparan sulfate on the ...
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Human Coronavirus NL63 Utilizes Heparan Sulfate Proteoglycans for Attachment to Target Cells
... that heparan sulfate proteoglycans function as adhesion molecules, increasing the virus density on cell surface and possibly facilitating the interaction between HCoV-NL63 and its re- ...
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Developmental roles of heparan sulfate proteoglycans: a comparative review in Drosophila, mouse and human
... affecting heparan sulfate proteoglycans that influence the function of growth factor pathways essential for tissue assembly, differentiation and ...their heparan sulfate chains have ...
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Augmented Synthesis and Differential Localization of Heparan Sulfate Proteoglycans in Duchenne Muscular Dystrophy
... of heparan sulfate proteo- glycans, specifically perlecan, syndecan-3, and ...these proteoglycans was observed in analyzed DMD samples, with glypican-1 and perlecan seemingly associated to the ECM, ...
Modulation of the Plasma Kallikrein-Kinin System Proteins Performed by Heparan Sulfate Proteoglycans
... H-kininogen. Heparan sulfate proteoglycans (HSPGs) play a critical role in either recruiting kinin precursors from the plasma, or in the assembly of kallikrein-kinin system components on the cell ...
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HB EGF function in cardiac valve development requires interaction with heparan sulfate proteoglycans
... *Author for correspondence ([email protected]) Accepted 3 May 2010 SUMMARY HB-EGF, a member of the EGF family of growth factors, plays an important role in cardiac valve development by suppressing mesenchymal ...
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Association of heparan sulfate proteoglycans SDC1 and SDC4 polymorphisms with breast cancer in an Australian Caucasian population
... survival. Heparan sulfate proteoglycans (HSPGs) are key components of the extracellular matrix (ECM) that mediate cell adhesion, motility, proliferation, invasion and cell ...
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Coordination of Heparan Sulfate Proteoglycans with Wnt Signaling To Control Cellular Migrations and Positioning in Caenorhabditis elegans
... ABSTRACT Heparan sulfates (HS) are linear polysaccharides with complex modification patterns, which are covalently bound via conserved attachment sites to core proteins to form heparan sulfate ...
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The Drosophila GOLPH3 homolog regulates the biosynthesis of heparan sulfate proteoglycans by modulating the retrograde trafficking of exostosins
... SUMMARY The exostosin (EXT) genes encode glycosyltransferases required for glycosaminoglycan chain polymerization in the biosynthesis of heparan sulfate proteoglycans (HSPGs). Mutations in the tumor ...
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APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa
... epithelium. Heparan sulfate proteoglycans (HSPGs) retained secreted APRIL in the subepithelium of the infected zone to create APRIL-rich niches, wherein IgG-producing plasma cells ...
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Laminins, via heparan sulfate proteoglycans, participate in zebrafish myotome morphogenesis by modulating the pattern of Bmp responsiveness
... matrix-associated heparan sulfate proteoglycans are absent in sly and their enzymatic removal mimics the sly ...via heparan sulfate proteoglycans, are instrumental in patterning ...
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Heparan Sulfate Proteoglycans Are Required for Cellular Binding of the Hepatitis E Virus ORF2 Capsid Protein and for Viral Infection
... surface heparan sulfate proteoglycans (HSPGs), specifically syndecans, play a crucial role in the binding of pORF2 to Huh-7 liver ...surface heparan sulfate by enzymatic (heparinase) or ...
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Liver heparan sulfate proteoglycans mediate clearance of triglyceride rich lipoproteins independently of LDL receptor family members
... hepatic heparan sulfate in triglyceride-rich lipoprotein metabolism by inactivating the biosynthetic gene GlcNAc N-deacetylase/N-sulfotransferase 1 (Ndst1) in hepatocytes using the Cre-loxP system, which ...
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Role of the extracellular domain of human herpesvirus 7 glycoprotein B in virus binding to cell surface heparan sulfate proteoglycans.
... surface heparan sulfate proteoglycans by heparinase and heparitinase but not by treatment with condroitinase ...when heparan sulfate-deficient mutant CHO cells were ...
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Wingless, Hedgehog and Heparan Sulfate Proteoglycans
... Altogether, Desbordes and Sanson’s results indicate that Hh is more sensitive to proteoglycans than is Wg signaling and that Dlp is probably playing a more important role than Dally. Further studies, however, are ...
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Functions of heparan sulfate proteoglycans in cell signaling during development
... Indeed, in striking contrast to the requirement for HSPGs for proper Dpp signaling during wing development, in sgl , sfl , ttv , sotv and botv mutant embryos, embryonic dorsoventral [r] ...
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Combinatorial Roles of Heparan Sulfate Proteoglycans and Heparan Sulfates in Caenorhabditis elegans Neural Development
... glypican is not required for HSN migration. Moreover, SDN-1 HS chains are important for HSN migration as sdn-1 null allele and ‘HS-less’ allele display identical phenotypes. Simultaneous genetic removal of both hst-2 and ...
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