Heparin Binding Growth Factor
Localization of heparin binding EGF like growth factor in the smooth muscle cells and macrophages of human atherosclerotic plaques
... Heparin-binding EGF-like growth factor (HB-EGF) is a potent chemoattractant and mitogen for smooth muscle cells (SMC) in culture. To elucidate whether HB-EGF is implicated in the pathogenesis ...
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Production of heparin binding epidermal growth factor like growth factor in the early phase of regeneration after acute renal injury Isolation and localization of bioactive molecules
... of heparin binding proteins. Heparin-binding proteins were purified by heparin affinity chromatography as previously de- scribed by Higashiyama et ...a heparin-sepharose col- umn ...
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Analysis of fibroblast growth factor-heparin interactions
... fibroblast growth factors (FGFs), HS binding controls their transport between cells and is required for the assembly of a high affinity signaling complex with the cognate FGF ...their heparin ...
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Heparin binding ligands mediate autocrine epidermal growth factor receptor activation In skin organ culture
... and heparin-binding EGF-like growth factor (HB-EGF) transcripts were rapidly and markedly induced, whereas EGF and TGF- a mRNAs were undetectable or only slightly ...permeability factor ...
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Heparin binding EGF like growth factor contributes to reduced glomerular filtration rate during glomerulonephritis in rats
... epidermal growth factor–like growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family, is expressed during inflammatory and pathological ...
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M2 macrophages induce ovarian cancer cell proliferation via a heparin binding epidermal growth factor/matrix metalloproteinase 9 intercellular feedback loop
... additional growth factor, the HB-EGF would be depleted from the media over ...of growth factor relative to the cellular receptor number ...transforming growth factor beta ...
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Heparin binding epidermal growth factor (HB EGF) drives EMT in patients with COPD: Implications for disease pathogenesis and novel therapies
... In COPD, there is emerging evidence of EMT being associated with airway remodelling and obliteration, which have been shown in idiopathic pulmonary fibrosis (IPF) and cancer (26- 28). EMT is now increasingly considered ...
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Modulation of fibroblast growth factor 2 receptor binding, dimerization, signaling, and angiogenic activity by a synthetic heparin mimicking polyanionic compound
... fibroblast growth factor (FGF-2) and other heparin-binding growth ...on binding to ...Unlike heparin, RG-13577 alone failed to mediate dimeriza- tion of ...abrogated ...
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Daily administration of low molecular weight heparin increases Hepatocyte Growth Factor serum levels in gynaecological patients: pharmacokinetic parameters and clinical implications
... which heparin increases HGF serum con- centration has yet to be completely ...that heparin could act by removing HGF from its binding to cell surface and matrix proteoglycans ...way, heparin ...
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The vasculature and its role in the damaged and healing tendon
... about growth factors and cytokines expressed in tendon wound healing and repair, although there have been a few studies ...fibroblast growth factor (bFGF) in a rabbit model of flexor tendon wound ...
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Heparin binding EGF like growth factor is an autocrine growth factor for human urothelial cells and is synthesized by epithelial and smooth muscle cells in the human bladder
... epidermal growth factor receptor (HER1) has been im- plicated in regenerative growth and proliferative diseases of the human bladder epithelium (urothelium), however a cog- nate HER1 ligand that can ...
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Augmented production of heparin binding mitogenic proteins by preadipocytes from massively obese persons
... Basic fibroblast growth factor (bFGF) stimulates the replication of preadipocytes and inhibits their differentiation. In this study we explored whether the same or related polypeptides were produced locally ...
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Induction of heparin binding epidermal growth factor like growth factor mRNA in rat kidney after acute injury
... identified heparin-binding EGF-like growth factor (HB-EGF) is regulated in response to renal injury induced by either ischemia/reperfusion or mercuric ...
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Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin binding growth factors for alveolar type II cells in fibroblast conditioned medium
... development and are important in the restoration of normal alveolar architecture after lung injury. To determine if fibroblasts are a source of soluble growth factors for alveolar type II cells, we investigated ...
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Original Article Expression of heparin-binding epidermal growth factor in the endometrium is positively correlated with IVF-ET pregnancy outcome
... special heparin binding domain, and it has strong mitogenic ...peptides, heparin- binding domain, epidermal growth factor-like domain, membrane proximal region, trans- membrane ...
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The role of heparan sulfates in fibroblast growth factor action
... 1989: Heparin-derived oligosaccharides: affinity for acidic fibroblast growth factor and effect on its growth-promoting activity for human endothelial cells.. 1989: Basic fibroblast grow[r] ...
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The effect of novel nitrogen-rich plasma polymer coatings on the phenotypic profile of notochordal cells
... In regards to proteoglycans, it has been previously shown that NP cells co-cultured with notochordal cells exhibited an increase in aggrecan (AGG) synthesis [8]. Interestingly, the expression of AGG in purified ...
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Heparin binding protein in patients with acute respiratory failure treated with granulocyte colony stimulating factor (filgrastim) – a prospective, placebo controlled, double blind study
... HBP: Heparin-binding protein; IQR: Interquartile range; G-CSF: Granulocyte colony stimulating factor; ICU: Intensive care unit; APACHE II: Acute physiology and chronic health evaluation; SOFA: ...
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THE INSULIN-LIKE GROWTH FACTORS.pdf
... The IGFs are believed to be important in fetal development, and direct evidence of a role for IGF-II in fetal growth has been demonstrated (38). IGF-I and -II mRNA transcripts are present in virtually all fetal ...
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Expression and clinical significance of IGF-1, IGFBP-3, and IGFBP-7 in serum and lung cancer tissues from patients with non-small cell lung cancer
... play an important role in the development of lung cancer, promoting proliferation of cancer cells and inhibiting their apoptosis. In this study, we also found that, in cases with lymph node metastasis, distant ...
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