Hepatic fibrogenesis
Identification of a novel TGF-β-miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesis
... in hepatic stellate cells (HSCs) and fibroblasts, the major sources of fibrogenic cells in liver ...in hepatic fibrogenesis, and suggest miR-122 as a promising molecular target for anti-fibrosis ...
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RSPOs facilitated HSC activation and promoted hepatic fibrogenesis
... Roof plate-specific spondin (RSPO) proteins are potent Wnt pathway agonists and involve in a broad range of developmental and physiological processes. This study investigated the activities and mechanisms of RSPOs in ...
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New Mechanism of Hepatic Fibrogenesis: Hepatitis C Virus Infection Induces Transforming Growth Factor β1 Production through Glucose-Regulated Protein 94
... of hepatic fibrosis? Studies have revealed that pa- tients with chronic HCV have higher levels of regulatory T (Treg) cells—which play important roles in immunological tolerance and viral persistence (42, 43)—in ...
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Molecular imaging of oxidized collagen quantifies pulmonary and hepatic fibrogenesis
... analyzed. Hepatic fibrosis increased with the duration of CCl 4 treatment, and resolved once the toxin was withdrawn, as assessed by Sirius Red staining (Figure ...
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The expression dynamics of transforming growth factor β/Smad signaling in the liver fibrosis experimentally caused by Clonorchis sinensis
... the hepatic fibrogenesis [18,19], and a few studies have ad- dressed about the activation of TGF-β/Smad signaling in fibrogenesis caused by parasitic infection, such as Schisto- soma ...of ...
8
ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model
... of hepatic inflammation; however, when this was reduced to base- line with ASK1i, there was no effect on lobular ...of hepatic fibrogenesis and fibrosis that can be impacted by therapeutic interven- ...
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The spleen in liver cirrhosis: revisiting an old enemy with novel targets
... fibrosis, hepatic stellate cells (HSCs) and Kupffer cells (KCs) act as the initial effectors of collagen deposition and inflammation modulation with the aid of the pro-fibrogenic cytokine transforming growth ...
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Methylation of RCAN1.4 mediated by DNMT1 and DNMT3b enhances hepatic stellate cell activation and liver fibrogenesis through Calcineurin/NFAT3 signaling
... a week. To investigate the functional role of RCAN1.4 in the progression of liver fibrosis, we specifically over-expressed RCAN1.4 in mice liver using rAAV8-packaged RCAN1.4 over-expression plasmid. Following the ...
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Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice
... The recent finding demonstrating that FHL2 controls liver homeostasis by co-ordinately regulating cell prolif- eration and cell death in hepatocytes [8] and our find- ings demonstrating that FHL2 might be an essential ...
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Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms
... Synectin deletion from HSC attenuates hepatic fibrogenesis in vivo. Synectin is known to play a key role in soluble fibronectin deposition in cancer-associated fibroblasts through an interaction with NRP-1 ...
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Preoperative evaluation of accessory hepatic ducts by drip infusion cholangiography with CT
... accessory hepatic ducts was reported to range from 2 to 11% in previous studies [1, 4–7], whereas it was 9% in this ...accessory hepatic ducts were pre- viously reported to range from 35 to ...accessory ...
6
microRNA 21 expressions impact on liver fibrosis in biliary atresia patients
... miRNAs, small non-coding RNAs that deregulate expression of gene at the posttranscriptional level, are stable and easily measureable in the patients’ tissue and blood specimens, including BA patients’ livers [7, 20–22]. ...
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A Dichotomous Key to the Species under Genus Metapenaeus Wood- Mason 1891 from Indian Water
... Branchiocardiac carina indistinct; telson with 3 pairs of movable lateral spines; thelycum with a median boss ………………..…..M. intermedius (Kishinouye 1900). 11. Postrostral carina ending near posterior margin of carapace; ...
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Renal tubular epithelium-targeted peroxisome proliferator- activated receptor-γ maintains the epithelial phenotype and antagonizes renal fibrogenesis
... Accumulating evidence suggests that loss of the renal tubular epithelial phenotype plays an important role in the pathogenesis of renal tubulointerstitial fibrosis. Systemic activation of peroxisome ...
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Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries
... Hepatocellular carcinoma (HCC) develops in response to chronic hepatic injury. Although p53 is usually regarded as a tumor suppressor, its constant activation can promote pro-tumorigenic inflammation, at least in ...
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Oryeongsan suppressed high glucose induced mesangial fibrosis
... Effect of Oryeongsan on HG-induced mesangial fibrosis This study evaluated whether HG stimulated mesangial cell fibrogenesis and whether Oryeongsan reversed it. Mesangial matrix accumulation was shown to be ...
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Arterial resection and reconstruction in pancreatectomy: surgical technique and outcomes
... In our series, the diameters of the HA and SMA were 2–3 mm and 6–8 mm, respectively. Thinner arterial walls secondary to tumor invasion, increases the risk for arterial thrombosis, anastomotic bleeding, and stenosis ...
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An exploratory study examining how nano-liquid chromatography–mass spectrometry and phosphoproteomics can differentiate patients with advanced fibrosis and higher percentage collagen in non-alcoholic fatty liver disease
... In addition to the clinical factors associated with ad- verse outcomes in NASH, a number of studies have assessed histologic features associated with mortality. In this context, the presence of histologic inflammation ...
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BCL6B expression in hepatocellular carcinoma and its efficacy in the inhibition of liver damage and fibrogenesis
... The lack of sensitive and reproducible markers for liver fibrosis has been a major limitation not only for research and the clinical management of liver diseases, but also for the development of anti-fibrotic drugs [23]. ...
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M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis
... Next, we investigated the possible signaling pathways in LR-MSCs that may be targeted by macrophage-induced LR-MSCs differentiation. The Wnt/β-catenin signaling has been extensively implicated in the differentiation of ...
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