Hepatic glucose output
The Acute Effect of Hydrocortisone on Hepatic Glucose Output and Peripheral Glucose Utilization
... The close correspondence between changes in Mean hepatic glucose output decreased significantly Table II from the control value of 48.5 the hepatic glucose output determined by measmg pe[r] ...
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In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects
... stimulate glucose disposal rate (Rd) and inhibit hepatic glucose output (HGO) in 12 nonobese and 10 obese subjects using the euglycemic clamp technique at insulin infusion rates of 15, 40, ...
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Lipid Transport in the Human Newborn: PALMITATE AND GLYCEROL TURNOVER AND THE CONTRIBUTION OF GLYCEROL TO NEONATAL HEPATIC GLUCOSE OUTPUT
... postabsorptive adult. Approximately 75% of transported glycerol was converted to glucose and represented 5.0±0.6% of hepatic glucose production. Furthermore, there was a direct relationship between ...
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An energetic tale of AMPK independent effects of metformin
... reducing hepatic glucose output, the molecular mechanism mediating this effect had remained elu- sive until ...on hepatic glucose output in primary hepatocytes; rather, their ...
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Basal Plasma Glucagon Levels of Man
... Although some increases in phosphorylase activity, hepatic glucose output, and the rate of rise of blood glucose concentration were seen in the seven experiments with human plasma, there[r] ...
9
Hepatic glucose sensing is required to preserve β cell glucose competence
... i.p. glucose injection (Figure 6, I and J), and was not related to a defect in plasma glucagon levels (Figure 6K), nor was it secondary to the development of insulin resistance as assessed by hyperinsuline- ...
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Effect of Intraduodenal Glucose Administration on Hepatic Extraction of Insulin in the Anesthetized Dog
... after glucose administration, the amount of insulin reaching the liver increased ...the glucose concentration of the femoral artery. After glucose administration, hepatic extraction of insulin ...
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THE PHYSIOLOGICAL SIGNIFICANCE OF THE SECRETION OF ENDOGENOUS INSULIN INTO THE PORTAL CIRCULATION III EVIDENCE FOR A DIRECT IMMEDIATE EFFECT OF INSULIN ON THE BALANCE OF GLUCOSE ACROSS THE LIVER
... Their failure to find a decrease in hepatic glucose output in the two other experiments in which a gradual decline in blood glucose concentration was produced by slow insulin infusion, m[r] ...
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CHLORPROPAMIDE INDUCED LEUCINE HYPOGLYCEMIA
... It is suggested that L-leucine acts similarly in all situations to inhibit hepatic glucose output and that the resultant fall in blood glucose concentration will vary considerably, depen[r] ...
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Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp
... the glucose clamp measure equivalent indices of insulin ...Euglycemic glucose clamps (glucose, G: 85 mg/dl) were performed at two rates of insulin (I) infusion (15 and 40 mU/min per m2) in 10 ...
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Differential Effects of Insulin on Splanchnic and Peripheral Glucose Disposal after an Intravenous Glucose Load in Man
... blood glucose was raised to comparable levels to those of controls ( 170 mg/dl) by a variable glucose ...net output of ...of hepatic glucose output (P < ...splanchnic ...
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THE EFFECT OF HEXAMETHONIUM BROMIDE ON SPLANCHNIC BLOOD FLOW, OXYGEN CONSUMPTION AND GLUCOSE OUTPUT IN MAN
... Three or four such determinations were made over twenty minutes and the results averaged to obtain the control values for splanchnic blood flow, hepatic glucose output, arterial lactic a[r] ...
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Relationships of generalized and regional adiposity to insulin sensitivity in men
... turnover) to total body adiposity (determined by hydrodensitometry) and regional adiposity. The latter was assessed by determining subcutaneous abdominal, intraperitoneal, and retroperitoneal fat masses (using magnetic ...
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INFANTS OF DIABETIC MOTHERS: ATTENUATED GLUCOSE UPTAKE WITHOUT HYPERINSULINEMIA DURING CONTINUOUS GLUCOSE INFUSION
... mg/kg/minute, while the rate in the adult dog is about 2 mg/kg/minute.26 In adult dog or man, hepatic glucose output ceases when exogenous glucose is infused at the basal rate.”’7 If glu[r] ...
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Serial Changes in Norepinephrine Kinetics Associated With Feeding Dogs a High Fat Diet
... In addition, all dogs received vitamin supplements (VAL syrup; Fort Dodge Laboratories, Fort Dodge, IA) and antibiotics throughout the entire study. The dogs were housed in air-conditioned cages and were fed between the ...
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A mathematical model of the euglycemic hyperinsulinemic clamp
... and glucose levels were ...Hyperinsulinemic glucose Clamp was performed according to ...the glucose and insu- lin levels were monitored every 5 min and every 20 min respectively, and the rate of ...
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Metabolic effects of the nocturnal rise in cortisol on carbohydrate metabolism in normal humans
... Glucocorticoid concentrations vary throughout the day. To determine whether an increase in cortisol similar to that present during sleep is of physiologic significance in humans, we studied the disposition of a mixed ...
9
Glucose reabsorption from bile Evidence for a biliohepatic circulation
... blood-bile glucose concentration difference, infusions of glucose were administered ...t-tubes. Glucose was assayed in plasma, bile, and rat liver by a hexokinase method specific for ...man, ...
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Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog
... 90-min glucose infusion ...peripheral glucose infusion periods (7 +/- 1, 7 +/- 1, 7 +/- 1 microU/ml; 100 +/- 3, 101 +/- 6, 101 +/- 3 pg/ml, ...the hepatic blood flow, glucose infusion rate, ...
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Hepatic glucose sensing: does flux matter?
... in glucose homeostasis by con- tinuously adapting its own metabolism to the availability of nutrients and overall energetic needs of the ...blood glucose concentration, only in recent years have we learned ...
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